TNF-α ribozymes

ABSTRACT

Enzymatic RNA molecules which cleave TNF-α mRNA.

RELATED APPLICATIONS

This application is a continuation-in-part of Sullivan and Draper,"Method and Reagent for Treatment of Inflammatory Disease", U.S. Ser.No. 07/989,849 (filed Dec. 7, 1992), now abandoned, and U.S. Ser. No.08/008,895 (filed Jan. 19, 1993), now abandoned, both herebyincorporated in their totality (in including drawings) by referenceherein.

FIELD OF THE INVENTION

The present invention relates to therapeutic compositions and methodsfor the treatment or diagnosis of diseases or conditions related toTNF-α levels, such as septic shock, rheumatoid arthritis, HIV and AIDS,psoriasis, inflammatory or autoimmune disorders.

BACKGROUND OF THE INVENTION

The following is a brief description of the physiological role of TNF-α.The discussion is not meant to be complete and is provided only forunderstanding of the invention that follows. This summary is not anadmission that any of the work described below is prior art to theclaimed invention.

The identification and cloning of the cytokines have provided a wealthof data on endogenous immunological and inflammatory mediators and theirrole in host defense against infection (van Deuren et al., 1992 J.Pathol. 168, 349-356). Cytokines also have been associated withpathology due to over-expression or inappropriate production. Cytokinecascades are implicated in the tissue damage that occurs during gramnegative septic shock (Parrillo, 1993 N. Engl. J. Med. 328, 1471-1477),in the joint inflammation and tissue destruction that occurs duringrheumatoid arthritis (Harris, 1990 N. Engl. J. Med. 322, 1277), and in apositive feedback loop between cytokine production and the replicationof human immunodeficiency virus (HIV) (Fauci, 1990 Lymphokine Res. 9,527-531). A common thread interweaving these pathological conditions istheir association with abnormally high levels of the proinflammatorycytokine tumor necrosis factor-α (TNF-α).

Tumor necrosis factor-α (TNF-α) is a protein, secreted by activatedleukocytes, that is a potent mediator of inflammatory reactions.Injection of TNF-α into experimental animals can simulate the symptomsof systemic and local inflammatory diseases such as septic shock orrheumatoid arthritis.

TNF-α was initially described as a factor secreted by activatedmacrophages which mediates the destruction of solid tumors in mice (Old,1985 Science 230, 4225-4231). TNF-α subsequently was found to beidentical to cachectin, an agent responsible for the weight loss andwasting syndrome associated with tumors and chronic infections (Beutler,et al., 1985 Nature 316, 552-554). The cDNA and the genomic locus forTNF-α have been cloned and found to be related to TNF-β (Shakhov et al.,1990 J. Exp. Med. 171, 35-47). Both TNF-α and TNF-β bind to the samereceptors and have nearly identical biological activities. The two TNFreceptors have been found on most cell types examined (Smith, et al.,1990 Science 248, 1019-1023). TNF-α secretion has been detected frommonocytes/macrophages, CD4+ and CD8+ T-cells, B-cells, lymphokineactivated killer cells, neutrophils, astrocytes, endothelial cells,smooth muscle cells, as well as various non-hematopoietic tumor celllines ( for a review see Turestskaya et al., 1991 in Tumor NecrosisFactor: Structure, Function, and Mechanism of Action B. B. Aggarwal, J.Vilcek, Eds. Marcel Dekker, Inc., pp. 35-60). TNF-α is regulatedtranscriptionally and translationally, and requires proteolyticprocessing at the plasma membrane in order to be secreted (Kriegler etal., 1988 Cell 53, 45-53). Once secreted, the serum half life of TNF-αis approximately 30 minutes. The tight regulation of TNF-α is importantdue to the extreme toxicity of this cytokine. Increasing evidenceindicates that overproduction of TNF-α during infections can lead tosevere systemic toxicity and death (Tracey & Cerami, 1992 Am. J. Trop.Med. Hyg. 47, 2-7).

Antisense RNA and Hammerhead ribozymes have been used in an attempt tolower the expression level of TNF-α by targeting specified cleavagesites Sioud et al., 1992 J. Mol. Biol. 223; 831; Sioud WO 94/10301;Kisich and co-workers, 1990 abstract (FASEB J. 4, A1860; 1991 slidepresentation (J. Leukocyte Biol. sup. 2, 70); December, 1992 posterpresentation at Anti-HIV Therapeutics Conference in SanDiego, Calif.;and "Development of anti-TNF-α ribozymes for the control of TNF-α geneexpression"--Kisich, Doctoral Dissertation, 1993 University ofCalifornia, Davis! listing various TNFα targeted ribozymes.

SUMMARY OF THE INVENTION

This invention relates to ribozymes, or enzymatic RNA molecules,directed to cleave mRNA species encoding specific sites in TNF-α. Inparticular, applicant describes the selection and function of ribozymescapable of cleaving this RNA and their use to reduce activity of TNF-αin various tissues to treat the diseases discussed herein. Suchribozymes are also useful for diagnostic applications.

Ribozymes that cleave the specified cites in TNF-α mRNA represent anovel therapeutic approach to inflammatory or autoimmune disorders.Applicant indicates that ribozymes are able to inhibit the activity ofTNF-α and that the catalytic activity of the ribozymes is required fortheir inhibitory effect. Those of ordinary skill in the art, will findthat it is clear from the examples described that other ribozymes thatcleave these sites in TNF-α encoding mRNAs may be readily designed andare within the invention.

Six basic varieties of naturally-occurring enzymatic RNAs are knownpresently. Each can catalyze the hydrolysis of RNA phosphodiester bondsin trans (and thus can cleave other RNA molecules) under physiologicalconditions. Table I summarizes some of the characteristics of theseribozymes. In general, enzymatic nucleic acids act by first binding to atarget RNA. Such binding occurs through the target binding portion of aenzymatic nucleic acid which is held in close proximity to an enzymaticportion of the molecule that acts to cleave the target RNA. Thus, theenzymatic nucleic acid first recognizes and then binds a target RNAthrough complementary base-pairing, and once bound to the correct site,acts enzymatically to cut the target RNA. Strategic cleavage of such atarget RNA will destroy its ability to direct synthesis of an encodedprotein. After an enzymatic nucleic acid has bound and cleaved its RNAtarget, it is released from that RNA to search for another target andcan repeatedly bind and cleave new targets.

The enzymatic nature of a ribozyme is advantageous over othertechnologies, such as antisense technology (where a nucleic acidmolecule simply binds to a nucleic acid target to block its translation)since the concentration of ribozyme necessary to affect a therapeutictreatment is lower than that of an antisense oligonucleotide. Thisadvantage reflects the ability of the ribozyme to act enzymatically.Thus, a single ribozyme molecule is able to cleave many molecules oftarget RNA. In addition, the ribozyme is a highly specific inhibitor,with the specificity of inhibition depending not only on the basepairing mechanism of binding to the target RNA, but also on themechanism of target RNA cleavage. Single mismatches, orbase-substitutions, near the site of cleavage can completely eliminatecatalytic activity of a ribozyme. Similar mismatches in antisensemolecules do not prevent their action (Woolf, T. M., et al., 1992, Proc.Natl. Acad. Sci. USA, 89, 7305-7309). Thus, the specificity of action ofa ribozyme is greater than that of an antisense oligonucleotide bindingthe same RNA site.

In preferred embodiments of this invention, the enzymatic nucleic acidmolecule is formed in a hammerhead or hairpin motif, but may also beformed in the motif of a hepatitis delta virus, group I intron or RNasePRNA (in association with an RNA guide sequence) or Neurospora VS RNA.Examples of such hammerhead motifs are described by Rossi et al., 1992,Aids Research and Human Retroviruses 8, 183, of hairpin motifs by Hampelet al., "RNA Catalyst for Cleaving Specific RNA Sequences," filed Sep.20, 1989, which is a continuation-in-part of U.S. Ser. No. 07/247,100filed Sep. 20, 1988, Hampel and Tritz, 1989 Biochemistry 28, 4929, andHampel et al., 1990 Nucleic Acids Res. 18, 299, and an example of thehepatitis delta virus motif is described by Perrotta and Been, 1992Biochemistry 31, 16; of the RNaseP motif by Guerrier-Takada et al., 1983Cell 35, 849, Neurospora VS RNA ribozyme motif is described by Collins(Saville and Collins, 1990 Cell 61, 685-696; Saville and Collins, 1991Proc. Natl. Acad. Sci. USA 88, 8826-8830; Collins and Olive, 1993Biochemistry 32, 2795-2799) and of the Group I intron by Cech et al.,U.S. Pat. No. 4,987,071. These specific motifs are not limiting in theinvention and those skilled in the art will recognize that all that isimportant in an enzymatic nucleic acid molecule of this invention isthat it has a specific substrate binding site which is complementary toone or more of the target gene RNA regions, and that it have nucleotidesequences within or surrounding that substrate binding site which impartan RNA cleaving activity to the molecule.

The invention provides a method for producing a class of enzymaticcleaving agents which exhibit a high degree of specificity for the RNAof a desired target. The enzymatic nucleic acid molecule is preferablytargeted to a highly conserved sequence region of a target TNF-αencoding mRNA such that specific treatment of a disease or condition canbe provided with either one or several enzymatic nucleic acids. Suchenzymatic nucleic acid molecules can be delivered exogenously tospecific cells as required. Alternatively, the ribozymes can beexpressed from DNA vectors that are delivered to specific cells.

Synthesis of nucleic acids greater than 100 nucleotides in length isdifficult using automated methods, and the therapeutic cost of suchmolecules is prohibitive. In this invention, small enzymatic nucleicacid motifs (e.g., of the hammerhead or the hairpin structure) are usedfor exogenous delivery. The simple structure of these moleculesincreases the ability of the enzymatic nucleic acid to invade targetedregions of the mRNA structure. However, these catalytic RNA moleculescan also be expressed within cells from eucaryotic promoters (e.g.,Scanlon et al., 1991, Proc. Natl. Acad. Sci. USA, 88, 10591-5;Kashani-Sabet et al., 1992 Antisense Res. Dev., 2, 3-15; Dropulic etal., 1992 J. Virol, 66, 1432-41; Weerasinghe et al., 1991 J. Virol, 65,5531-4; Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89, 10802-6; Chenet al., 1992 Nucleic Acids Res., 20, 4581-9; Sarver et al., 1990 Science247, 1222-1225). Those skilled in the art realize that any ribozyme canbe expressed in eucaryotic cells from the appropriate DNA vector. Theactivity of such ribozymes can be augmented by their release from theprimary transcript by a second ribozyme (Draper et al., PCT WO 93/23569,and Sullivan et al., PCT WO94/02595, both hereby incorporated in theirtotality by reference herein; Ohkawa et al., 1992 Nucleic Acids Symp.Ser., 27, 15-6; Taira et al., 1991, Nucleic Acids Res., 19, 5125-30;Ventura et al., 1993 Nucleic Acids Res., 21, 3249-55).

Inflammatory mediators such as lipopolysaccharide (LPS), interleukin-1(IL-1) or tumor necrosis factor-a (TNF-α) act on cells by inducingtranscription of a number of secondary mediators, including othercytokines and adhesion molecules. Ribozyme therapy, due to its exquisitespecificity, is particularly well-suited to target intracellular factorsthat contribute to disease pathology. Thus, ribozymes that cleave themRNA sites encoded by TNF-α may represent novel therapeutics for thetreatment of inflammatory and autoimmune disorders.

Thus, in a first aspect, the invention features ribozymes that inhibitTNF-α production by cleavage at designated sites in TNF-α encoding mRNA.These chemically or enzymatically synthesized RNA molecules containsubstrate binding domains that bind to accessible regions of theirtarget mRNAs. The RNA molecules also contain domains that catalyze thecleavage of RNA. The RNA molecules are preferably ribozymes of thehammerhead or hairpin motif. Upon binding, the ribozymes cleave thetarget TNF-α encoding mRNAs, preventing translation and TNF-α proteinaccumulation. In the absence of the expression of the target gene, atherapeutic effect may be observed.

By "inhibit" is meant that the activity or level of TNF-α encoding mRNAis reduced below that observed in the absence of the ribozyme, andpreferably is below that level observed in the presence of an inactiveRNA molecule able to bind to the same site on the mRNA, but unable tocleave that RNA.

Such ribozymes are useful for the prevention of the diseases andconditions discussed above, and any other diseases or conditions thatare related to the level of TNF-α activity in a cell or tissue. By"related" is meant that the inhibition of TNF-α mRNA and thus reductionin the level of TNF-α activity will relieve to some extent the symptomsof the disease or condition.

Ribozymes are added directly, or can be complexed with cationic lipids,packaged within liposomes, or otherwise delivered to target cells. TheRNA or RNA complexes can be locally administered to relevant tissues exvivo, or in vivo through injection, infusion pump or stent, with orwithout their incorporation in biopolymers. In preferred embodiments,the ribozymes have binding arms which are complementary to the sequencesin Tables II, IV, VI-VII. Examples of such ribozymes are shown in TablesIII, V-VII. Examples of such ribozymes consist essentially of sequencesdefined in these Tables. By "consists essentially of" is meant that theactive ribozyme contains an enzymatic center equivalent to those in theexamples, and binding arms able to bind mRNA such that cleavage at thetarget site occurs. Other sequences may be present which do notinterfere with such cleavage.

In another aspect of the invention, ribozymes that cleave targetmolecules and inhibit TNF-α activity are expressed from transcriptionunits inserted into DNA, RNA, or viral vectors. Preferably, therecombinant vectors capable of expressing the ribozymes are locallydelivered as described above, and transiently persist in target cells.Once expressed, the ribozymes cleave the target mRNA. The recombinantvectors are preferably DNA plasmids or adenovirus vectors. However,other mammalian cell vectors that direct the expression of RNA may beused for this purpose.

Other features and advantages of the invention will be apparent from thefollowing description of the preferred embodiments thereof, and from theclaims.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The drawings will first briefly be described.

Drawings:

FIG. 1 is a diagrammatic representation of the hammerhead ribozymedomain known in the art. Stem II can be ≧2 base-pair long, or can evenlack base pairs and consist of a loop region.

FIG. 2a is a diagrammatic representation of the hammerhead ribozymedomain known in the art; FIG. 2b is a diagrammatic representation of thehammerhead ribozyme as divided by Uhlenbeck (1987, Nature, 327, 596-600)into a substrate and enzyme portion; FIG. 2c is a similar diagramshowing the hammerhead divided by Haseloff and Gerlach (1988, Nature,334, 585-591) into two portions; and FIG. 2d is a similar diagramshowing the hammerhead divided by Jeffries and Symons (1989, Nucl.Acids. Res., 17, 1371-1371) into two portions.

FIG. 3 is a representation of the general structure of the hairpinribozyme domain known in the art. H, is A, U or C. Y is U or C. N is A,U, G, or C. N' is the complementary sequence of N. Helix 4 can be ≧2base-pair long.

FIG. 4 is a representation of the general structure of the hepatitisdelta virus ribozyme domain known in the art.

FIG. 5 is a representation of the general structure of the VS RNAribozyme domain.

FIG. 6 is a schematic representation of an RNAseH accessibility assay.Specifically, the left side of FIG. 6 is a diagram of complementary DNAoligonucleotides bound to accessible sites on the target RNA.Complementary DNA oligonucleotides are represented by broad lineslabeled A, B, and C. Target RNA is represented by the thin, twistedline. The right side of FIG. 6 is a schematic of a gel separation ofuncut target RNA from a cleaved target RNA. Detection of target RNA isby autoradiography of body-labeled, T7 transcript. The bands common toeach lane represent uncleaved target RNA; the bands unique to each lanerepresent the cleaved products.

FIG. 7 schematic representation of hairpin ribozymes targeted againstsites in TNF-α mRNA. Helix1 and Helix2 represents intermolecular helicesformed between ribozyme and the target RNA. Helix3 and Helix4 representsintramolecular helices within the ribozyme. The arrow indicates the siteof cleavage. Circled nucleotides are mutations that render the ribozymecatalytically inactive. A) Structure of the hairpin ribozyme.substratecomplex for site 1393 in mouse TNF-α mRNA. B) Structure of the hairpinribozyme·substrate complex for site 1435 in mouse TNF-α mRNA.

FIG. 8 shows the 1393 hairpin ribozyme-mediated inhibition of TNF-αexpression in mouse macrophages.

FIG. 9 shows the 1435 hairpin ribozyme-mediated inhibition of TNF-αexpression in mouse macrophages.

Ribozymes

Ribozymes of this invention block to some extent TNF-α expression andcan be used to treat disease or diagnose such disease. Ribozymes will bedelivered to cells in culture and to cells or tissues in animal modelsof septic shock and rheumatoid arthritis. Ribozyme cleavage of TNF-αmRNA in these systems may prevent inflammatory cell function andalleviate disease symptoms.

Target sites

Targets for useful ribozymes can be determined as disclosed in Draper etal supra. Sullivan et al., supra, as well as by Draper et al., "Methodand reagent for treatment of arthritic conditions" U.S. Ser. No.08/152,487, filed Nov. 12, 1993, and hereby incorporated by referenceherein in totality. Rather than repeat the guidance provided in thosedocuments here, below are provided specific examples of such methods,not limiting to those in the art. Ribozymes to such targets are designedas described in those applications and synthesized to be tested in vitroand in vivo, as also described. Such ribozymes can also be optimized anddelivered as described therein. While specific examples to mouse andhuman RNA are provided, those in the art will recognize that theequivalent human RNA targets described can be used as described below.Thus, the same target may be used, but binding arms suitable fortargeting human RNA sequences are present in the ribozyme. Such targetsmay also be selected as described below.

The sequence of human and mouse TNF-α mRNA can be screened foraccessible sites using a computer folding algorithm. Hammerhead orhairpin ribozyme cleavage sites were identified. These sites are shownin Tables II, IV, and VI-VII. (All sequences are 5' to 3' in thetables.) While mouse and human sequences can be screened and ribozymesthereafter designed, the human targeted sequences are of most utility.However, as discussed in Stinchcomb et al., "Method and Composition forTreatment of Restenosis and Cancer Using Ribozymes," filed May 18, 1994,U.S. Ser. No. 08/245,466,(and hereby incorporated herein by reference),mouse targeted ribozymes are useful to test efficacy of action of theribozyme prior to testing in humans. The nucleotide base position isnoted in the Tables as that site to be cleaved by the designated type ofribozyme. (In Table III, lower case letters indicate positions that arenot conserved between the human and the mouse TNF-α sequences.)

Hammerhead ribozymes are designed that could bind and are individuallyanalyzed by computer folding (Jaeger et al., 1989 Proc. Natl. Acad. Sci.USA, 86, 7706-7710) to assess whether the ribozyme sequences fold intothe appropriate secondary structure. Those ribozymes with unfavorableintramolecular interactions between the binding arms and the catalyticcore are eliminated from consideration. Varying binding arm lengths canbe chosen to optimize activity. Generally, at least 5 bases on each armare able to bind to, or otherwise interact with, the target RNA.

Referring to FIG. 6, mRNA is screened for accessible cleavage sites bythe method described generally in McSwiggen, U.S. patent applicationSer. No. 07/883,849 filed on May 1, 1992, entitled "Assay for ribozymetarget site", hereby incorporated by reference herein. Briefly, DNAoligonucleotides representing potential hammerhead or hairpin ribozymecleavage sites are synthesized. A polymerase chain reaction is used togenerate a substrate for T7 RNA polymerase transcription from human ormurine TNF-α cDNA clones. Labeled RNA transcripts are synthesized invitro from the two templates. The oligonucleotides and the labeledtranscripts are annealed, RNAseH is added and the mixtures are incubatedfor the designated times at 37° C. Reactions are stopped and RNAseparated on sequencing polyacrylamide gels. The percentage of thesubstrate cleaved is determined by autoradiographic quantitation using aPhosphor Imaging system. From these data, hammerhead or hairpin ribozymesites are chosen as the most accessible.

Ribozymes of the hammerhead or hairpin motif are designed to anneal tovarious sites in the mRNA message. The binding arms are complementary tothe target site sequences described above. The ribozymes are chemicallysynthesized. The method of synthesis used follows the procedure fornormal RNA synthesis as described in Usman et al., 1987 J. Am. Chem.Soc.. 109, 7845-7854 and in Scaringe et al., 1990 Nucleic Acids Res..18, 5433-5441 and makes use of common nucleic acid protecting andcoupling groups, such as dimethoxytrityl at the 5'-end, andphosphoramidites at the 3'-end. The average stepwise coupling yieldswere >98%. Inactive ribozymes were synthesized by substituting a U forG₅ and a U for A₁₄ (numbering from Hertel et al., 1992 Nucleic AcidsRes., 20, 3252). Hairpin ribozymes are synthesized in two parts andannealed to reconstruct the active ribozyme (Chowrira and Burke, 1992Nucleic Acids Res., 20, 2835-2840). Hairpin ribozymes are alsosynthesized from DNA templates using bacteriophage T7 RNA polymerase(Milligan and Uhlenbeck, 1989, Methods Enzymol. 180, 51). All ribozymesare modified to enhance stability by modification of fiveribonucleotides at both the 5' and 3' ends with 2'-O-methyl groups.Ribozymes are purified by gel electrophoresis using general methods orare purified by high pressure liquid chromatography (HPLC; See Usman etal., Synthesis, deprotection, analysis and purification of RNA andribozymes, filed May, 18, 1994, U.S. Ser. No. 08/245,736 the totality ofwhich is hereby incorporated herein by reference) and are resuspended inwater.

The sequences of the chemically synthesized ribozymes useful in thisstudy are shown in Tables III, V-VII. Those in the art will recognizethat these sequences are representative only of many more such sequenceswhere the enzymatic portion of the ribozyme (all but the binding arms)is altered to affect activity. For example, stem-loop 11 sequence ofhammerhead ribozymes listed in Tables III and V (5'-GGCCGAAAGGCC-3') canbe altered (substitution, deletion, and/or insertion) to contain anysequences provided a minimum of two base-paired stem structure can form.Similarly, stem-loop IV sequence of hairpin ribozymes listed in TablesVI and VII (5'-CACGUUGUG-3') can be altered (substitution, deletion,and/or insertion) to contain any sequence, provided a minimum of twobase-paired stem structure can form. The sequences listed in Tables III,V-VII may be formed of ribonucleotides or other nucleotides ornon-nucleotides. Such ribozymes are equivalent to the ribozymesdescribed specifically in the Tables.

Optimizing Ribozyme Activity

Ribozyme activity can be optimized as described by Stinchcomb et al.,supra. The details will not be repeated here, but include altering thelength of the ribozyme binding arms (stems I and III, see FIG. 2c), orchemically synthesizing ribozymes with modifications that prevent theirdegradation by serum ribonucleases (see e.g., Eckstein et al.,International Publication No. WO 92/07065; Perrault et al., 1990 Nature344, 565; Pieken et al., 1991 Science 253, 314; Usman and Cedergren,1992 Trends in Biochem. Sci. 17, 334; Usman et al., InternationalPublication No. WO 93/15187; and Rossi et al., International PublicationNo. WO 91/03162, as well as Usman, N. et al. U.S. patent applicationSer. No. 07/829,729, and Sproat, European Patent Application 92110298.4and U.S. Pat. No. 5,334,711 and Jennings et al., WO 94/13688 whichdescribe various chemical modifications that can be made to the sugarmoieties of enzymatic RNA molecules. Modifications which enhance theirefficacy in cells, and removal of stem 11 bases to shorten RNA synthesistimes and reduce chemical requirements. (All these publications arehereby incorporated by reference herein.),

Sullivan, et al., supra, describes the general methods for delivery ofenzymatic RNA molecules . Ribozymes may be administered to cells by avariety of methods known to those familiar to the art, including, butnot restricted to, encapsulation in liposomes, by iontophoresis, or byincorporation into other vehicles, such as hydrogels, cyclodextrins,biodegradable nanocapsules, and bioadhesive microspheres. For someindications, ribozymes may be directly delivered ex vivo to cells ortissues with or without the aforementioned vehicles. Alternatively, theRNA/vehicle combination is locally delivered by direct injection or byuse of a catheter, infusion pump or stent. Other routes of deliveryinclude, but are not limited to, intravascular, intramuscular,subcutaneous or joint injection, aerosol inhalation, oral (tablet orpill form), topical, systemic, ocular, intraperitoneal and/orintrathecal delivery. More detailed descriptions of ribozyme deliveryand administration are provided in Sullivan et al., supra and Draper etal., supra which have been incorporated by reference herein.

Another means of accumulating high concentrations of a ribozyme(s)within cells is to incorporate the ribozyme-encoding sequences into aDNA expression vector. Transcription of the ribozyme sequences aredriven from a promoter for eucaryotic RNA polymerase I (pol I), RNApolymerase II (pol II), or RNA polymerase III (pol III). Transcriptsfrom pol II or pol III promoters will be expressed at high levels in allcells; the levels of a given pol II promoter in a given cell type willdepend on the nature of the gene regulatory sequences (enhancers,silencers, etc.) present nearby. Prokaryotic RNA polymerase promotersare also used, providing that the prokaryotic RNA polymerase enzyme isexpressed in the appropriate cells (Elroy-Stein and Moss, 1990 Proc.Natl. Acad. Sci. U S A, 87, 6743-7; Gao and Huang 1993 Nucleic AcidsRes., 21, 2867-72; Lieber et al., 1993 Methods Enzymol., 217, 47-66;Zhou et al., 1990 Mol. Cell. Biol., 10, 4529-37). Several investigatorshave demonstrated that ribozymes expressed from such promoters canfunction in mammalian cells (e.g. Kashani-Sabet et al., 1992 AntisenseRes. Dev., 2, 3-15; Ojwang et al., 1992 Proc. Natl. Acad. Sci. U S A,89, 10802-6; Chen et al., 1992 Nucleic Acids Res., 20, 4581-9; Yu etal., 1993 Proc. Natl. Acad. Sci. U S A, 90, 6340-4; L'Huillier et al.,1992 EMBO J. 11, 4411-8; Lisziewicz et al., 1993 Proc. NatI. Acad. Sci.U.S.A., 90, 8000-4). The above ribozyme transcription units can beincorporated into a variety of vectors for introduction into mammaliancells, including but not restricted to, plasmid DNA vectors, viral DNAvectors (such as adenovirus or adeno-associated virus vectors), or viralRNA vectors (such as retroviral, sindbis virus, semliki forest virusvectors).

In a preferred embodiment of the invention, a transcription unitexpressing a ribozyme that cleaves TNF-α RNA is inserted into a plasmidDNA vector or an adenovirus DNA viral vector. Both vectors have beenused to transfer genes to the intact vasculature or to joints of liveanimals (Willard et al., 1992 Circulation, 86,1-473.; Nabel et al., 1990Science, 249, 1285-1288) and both vectors lead to transient geneexpression. The adenovirus vector is delivered as recombinant adenoviralparticles. DNA may be delivered alone or complexed with vehicles (asdescribed for RNA above). The DNA, DNA/vehicle complexes, or therecombinant adenovirus particles are locally administered to the site oftreatment, e.g., through the use of an injection catheter, stent orinfusion pump or are directly added to cells or tissues ex vivo.

In another preferred embodiment of the invention, a transcription unitexpressing a ribozyme that cleaves TNF-a RNA is inserted into aretrovirus vector for sustained expression of ribozyme(s).

EXAMPLE 1

TNF-α Hammerhead ribozymes

By engineering ribozyme motifs we have designed several ribozymesdirected against TNF-α mRNA sequences. These ribozymes are synthesizedwith modifications that improve their nuclease resistance. The abilityof ribozymes to cleave TNF-α target sequences in vitro is evaluated.

The ribozymes will be tested for function in cells by analyzingbacterial lipopolysaccharide (LPS)-induced TNF-α expression levels.Ribozymes will be delivered to cells by incorporation into liposomes, bycomplexing with cationic lipids, by microinjection, or by expressionfrom DNA vectors. TNF-α expression will be monitored by ELISA, byindirect immunofluoresence, and/or by FACS analysis. TNF-α mRNA levelswill be assessed by Northern analysis, RNAse protection, primerextension analysis or quantitative RT-PCR. Ribozymes that block theinduction of TNF-α activity and/or TNF-α mRNA by more than 90% will beidentified.

RNA ribozymes and/or genes encoding them will be locally delivered tomacrophages by intraperitoneal injection. After a period of ribozymeuptake, the peritoneal macrophages are harvested and induced ex vivowith LPS. The ribozymes that significantly reduce TNF-α secretion areselected. The TNF-α can also be induced after ribozyme treatment withfixed Streptococcus in the peritoneal cavity instead of ex vivo. In thisfashion the ability of TNF-α ribozymes to block TNF-α secretion in alocalized inflammatory response are evaluated. In addition, we willdetermine if the ribozymes can block an ongoing inflammatory response bydelivering the TNF-α ribozymes after induction by the injection of fixedStreptococcus.

To examine the effect of anti-TNF-α ribozymes on systemic inflammation,the ribozymes are delivered by intravenous injection. The ability of theribozymes to inhibit TNF-α secretion and lethal shock caused by systemicLPS administration are assessed. Similarly, TNF-α ribozymes can beintroduced into the joints of mice with collagen-induced arthritis.Either free delivery, liposome delivery, cationic lipid delivery,adeno-associated virus vector delivery, adenovirus vector delivery,retrovirus vector delivery or plasmid vector delivery in these animalmodel experiments can be used to supply ribozymes. One dose (or a fewinfrequent doses) of a stable anti-TNF-α ribozyme or a gene constructthat constitutively expresses the ribozyme may abrogate tissue damage inthese inflammatory diseases.

EXAMPLE 2

Targeting mouse TNF-α mRNA for cleavage by hairpin ribozymes

Design of Hairpin ribozymes:

As shown in FIG. 7, two hairpin ribozymes were designed to cleave twodistinct sites (1393 and 1435) within the mouse TNF-α mRNA.Corresponding ribozymes were synthesized containing mutations in thecatalytic core of the ribozyme which renders the ribozyme inactive(Berzal-Herranz et al., 1993 EMBO J. 12, 2567). To construct theseribozymes, partially overlapping top- and bottom-strand oligonucleotides(˜50 nucleotides) were designed to include sequences for the T7 promoterand the hairpin ribozyme. The single-strand portions of annealedoligonucleotides were converted to double-strands using Sequenase (U.S.Biochemicals). Transcription reactions containing linear double-strandedtemplates were carried out essentially as described (Milligan &Uhlenbeck, 1989 supra) using the T7 mega shortscript kit (Ambion,Austin, Tex.).

Macrophage isolation.

To produce responsive macrophages 1 ml of sterile fluid thioglycollatebroth (Difco, Detroit, Mich.) was injected i.p. into 6 week old femaleC57bl/6NCR mice 3 days before peritoneal lavage. Mice were maintained asspecific pathogen free in autoclaved cages in a laminar flow hood andgiven sterilized water to minimize "spontaneous" activation ofmacrophages. The resulting peritoneal exudate cells (PEC) were obtainedby lavage using Hanks balanced salt solution (HBSS) and were plated at2.5×10⁵ /well in 96 well plates (Costar, Cambridge, Mass.) with Eaglesminimal essential medium (EMEM) containing 10% heat inactivated fetalbovine serum. After adhering for 2 hours the wells were washed to removenon-adherent cells. The resulting cultures were 97% macrophages asdetermined by morphology and staining for non-specific esterase.

Transfection of ribozymes into macrophages:

The ribozymes were diluted to 2×final concentration, mixed with an equalvolume of 11 nM lipofectamine (Life Technologies, Gaithersburg, Md.),and vortexed. 100 ml of lipid:ribozyme complex was then added directlyto the cells, followed immediately by 10 ml fetal bovine serum. Threehours after ribozyme addition 100 ml of 1 mg/ml bacteriallipopolysaccaride (LPS) was added to each well to stimulate TNFproduction.

Quantitation of TNF-α in mouse macrophages:

Supernatants were sampled at 0, 2, 4, 8, and 24 hours post LPSstimulation and stored at -70° C. Quantitation of TNF-α was done by aspecific ELISA. ELISA plates were coated with rabbit anti-mouse TNF-αserum at 1:1000 dilution (Genzyme) followed by blocking with milkproteins and incubation with TNF-α containing supernatants. TNF-α wasthen detected using a murine TNF-a specific hamster monoclonal antibody(Genzyme). The ELISA was developed with goat anti-hamster IgG coupled toalkaline phosphatase.

Assessment of reagent toxicity:

Following ribozyme/lipid treatment of macrophages and harvesting ofsupernatants viability of the cells was assessed by incubation of thecells with 5 mg/ml of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). This compound is reduced by the mitochondrialdihydrogenases, the activity of which correlates well with cellviability. After 12 hours the absorbance of reduced MTT is measured at585 nm.

Inhibition of TNF-α expression by hairpin ribozymes in mousemacrophages:

As shown in FIGS. 8 and 9, expression of TNF-α is significantlyinhibited by both hairpin ribozymes 1393 and 1435. The inhibition ofTNF-α expression by the ribozyme 1435 (active) appears to be dependenton the catalytic activity of the ribozyme: a catalytically inactivehairpin ribozyme (1435 dead) does not show appreciable inhibition. Incontrast, the inactive version of the 1393 ribozyme does show someinhibition of TNF-α expression at 162 nM ribozyme concentration. Thisinhibition may be attributed to ribozyme binding to the target sequence.

Sequences in FIG. 7 are non-limiting examples. Those in the art willrecognize that these are but example, and other embodiments can bereadily generated using techniques generally known in the art.

Uses

The association between TNF-α and bacterial sepsis, rheumatoidarthritis, and autoimmune disease make TNF-α an attractive target fortherapeutic intervention Tracy & Cerami 1992 supra; Williams et al.,1992 Proc. Natl. Acad. Sci. USA 89, 9784-9788; Jacob, 1992 J. Autoimmun.5 (Supp. A), 133-143!.

Septic Shock

Septic shock is a complication of major surgery, bacterial infection,and polytrauma characterized by high fever, increased cardiac output,reduced blood pressure and a neutrophilic infiltrate into the lungs andother major organs (Parrillo, 1993 supra). Current treatment options arelimited to antibiotics to reduce the bacterial load and non-steroidalanti-inflammatories to reduce fever. Despite these treatments in thebest intensive care settings, mortality from septic shock averages 50%,due primarily to multiple organ failure and disseminated vascularcoagulation. Septic shock, with an incidence of 200,000 cases per yearin the United States, is the major cause of death in intensive careunits. In septic shock syndrome, tissue injury or bacterial productsinitiate massive immune activation, resulting in the secretion ofpro-inflammatory cytokines which are not normally detected in the serum,such as TNF-α, interleukin-1β (IL-1β), γ-interferon (IFN-γ),interleukin-6 (IL-6), and interleukin-8 (IL-8). Other non-cytokinemediators such as leukotriene b4, prostaglandin E2, C3a and C3d alsoreach high levels (de Boer et al., 1992 Immunopharmacology 24, 135-148).

TNF-α is detected early in the course of septic shock in a largefraction of patients (de Boer et al., 1992 supra). In animal models,injection of TNF-α has been shown to induce shock-like symptoms similarto those induced by LPS injection (Beutler et al., 1985 Science 229,869-871); in contrast, injection of IL-1β, IL-6, or IL-8 does not induceshock. Injection of TNF-α also causes an elevation of IL-1β, IL-6, IL-8,PgE₂, acute phase proteins, and TxA₂ in the serum of experimentalanimals (de Boer et al., 1992 supra). In animal models the lethaleffects of LPS can be blocked by preadministration of anti-TNF-αantibodies. The cumulative evidence indicates that TNF-α is a key playerin the pathogenesis of septic shock, and therefore a good candidate fortherapeutic intervention.

Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized bychronic inflammation of the joints leading to bone destruction and lossof joint function (Harris, 1990 supra). At the cellular level,autoreactive T-lymphocytes and monocytes are typically present, and thesynoviocytes often have altered morphology and immunostaining patterns.RA joints have been shown to contain elevated levels of TNF-α, IL-1α andIL-1β, IL-6, GM-CSF, and TGF-β (Abney et al., 1991 Imm. Rev. 119,105-123), some or all of which may contribute to the pathological courseof the disease.

Cells cultured from RA joints spontaneously secrete all of thepro-inflammatory cytokines detected in vivo. Addition of antiseraagainst TNF-α to these cultures has been shown to reduce IL-1α/βproduction by these cells to undetectable levels (Abney et al., 1991Supra). Thus, TNF-α may directly induce the production of othercytokines in the RA joint. Addition of the anti-inflammatory cytokine,TGF-β, has no effect on cytokine secretion by RA cultures.Immunocytochemical studies of human RA surgical specimens clearlydemonstrate the production of TNF-α, IL-1α/β, and IL-6 from macrophagesnear the cartilage/pannus junction when the pannus in invading andovergrowing the cartilage (Chu et al., 1992 Br. J. Rheumatology 31,653-661). GM-CSF was shown to be produced mainly by vascular endotheliumin these samples. Both TNF-α and TGF-β have been shown to be fibroblastgrowth factors, and may contribute to the accumulation of scar tissue inthe RA joint. TNF-α has also been shown to increase osteoclast activityand bone resorbtion, and may have a role in the bone erosion commonlyfound in the RA joint (Cooper et al., 1992 Clin. Exp. Immunol. 89,244-250).

Elimination of TNF-α from the rheumatic joint would be predicted toreduce overall inflammation by reducing induction of MHC class II,IL-1α/β, II-6, and GM-CSF, and reducing T-cell activation. Osteoclastactivity might also fall, reducing the rate of bone erosion at thejoint. Finally, elimination of TNF-α would be expected to reduceaccumulation of scar tissue within the joint by removal of a fibroblastgrowth factor.

Treatment with an anti-TNF-a antibody reduces joint swelling and thehistological severity of collagen-induced arthritis in mice (Williams etal., 1992 Proc. Natl. Acad. Sci. USA 89, 9784-9788). In addition, astudy of RA patients who have received i.v. infusions of anti-TNF-αmonoclonal antibody reports a reduction in the number and severity ofinflamed joints after treatment. The benefit of monoclonal antibodytreatment in the long term may be limited by the expense andimmunogenicity of the antibody.

Psoriasis

Psoriasis is an inflammatory disorder of the skin characterized bykeratinocyte hyperproliferation and immune cell infiltrate (Kupper, 1990J. Clin. Invest. 86, 1783-1789). It is a fairly common condition,affecting 1.5-2.0% of the population. The disorder ranges in severityfrom mild, with small flaky patches of skin, to severe, involvinginflammation of the entire epidermis. The cellular infiltrate ofpsoriasis includes T-lymphocytes, neutrophils, macrophages, and dermaldendrocytes. The majority of T-lymphocytes are activated CD4⁺ cells ofthe T_(H) -1 phenotype, although some CD8⁺ and CD4⁻ /CD8⁻ are alsopresent. B lymphocytes are typically not found in abundance in psoriaticplaques.

Numerous hypotheses have been offered as to the proximal cause ofpsoriasis including auto-antibodies and auto-reactive T-cells,overproduction of growth factors, and genetic predisposition. Althoughthere is evidence to support the involvement of each of these factors inpsoriasis, they are neither mutually exclusive nor are any of themnecessary and sufficient for the pathogenesis of psoriasis (Reeves, 1991Semin. Dermatol. 10, 217).

The role of cytokines in the pathogenesis of psoriasis has beeninvestigated. Among those cytokines found to be abnormally expressedwere TGF-α, IL-1α, IL-1β, IL-1ra, IL-6, IL-8, IFN-γ, and TNF-α. Inaddition to abnormal cytokine production, elevated expression of ICAM-1,ELAM-1, and VCAM has been observed (Reeves, 1991 supra). This cytokineprofile is similar to that of normal wound healing, with the notableexception that cytokine levels subside upon healing. Keratinocytesthemselves have recently been shown to be capable of secreting EGF,TGF-α, IL-6, and TNF-α, which could increase proliferation in anautocrine fashion (Oxholm et al., 1991 APMIS 99, 58-64).

Nickoloff et al., 1993 (J Dermatol Sci. 6, 127-33) have proposed thefollowing model for the initiation and maintenance of the psoriaticplaque:

Tissue damage induces the wound healing response in the skin.Keratinocytes secrete IL-1α, IL-1β, IL-6, IL-8, TNF-α. These factorsactivate the endothelium of dermal capillaries, recruiting PMNs,macrophages, and T-cells into the wound site.

Dermal dendrocytes near the dermal/epidermal junction remain activatedwhen they should return to a quiescent state, and subsequently secretecytokines including TNF-α, IL-6, and IL-8. Cytokine expression, in turn,maintains the activated state of the endothelium, allowing extravasationof additional immunocytes, and the activated state of the keratinocyteswhich secrete TGF-α and IL-8. Keratinocyte IL-8 recruits immunocytesfrom the dermis into the epidermis. During passage through the dermis,T-cells encounter the activated dermal dendrocytes which efficientlyactivate the T_(H) -1 phenotype. The activated T-cells continue tomigrate into the epidermis, where they are stimulated bykeratinocyte-expressed ICAM-1 and MHC class II. IFN-γ secreted by theT-cells synergizes with the TNF-α from dermal dendrocytes to increasekeratinocyte proliferation and the levels of TGF-α, IL-8, and IL-6production. IFN-γ also feeds back to the dermal dendrocyte, maintainingthe activated phenotype and the inflammatory cycle.

Elevated serum titres of IL-6 increases synthesis of acute phaseproteins including complement factors by the liver, and antibodyproduction by plasma cells. Increased complement and antibody levelsincreases the probability of autoimmune reactions.

Maintenance of the psoriatic plaque requires continued expression of allof these processes, but attractive points of therapeutic interventionare TNF-α expression by the dermal dendrocyte to maintain activatedendothelium and keratinocytes, and IFN-γ expression by T-cells tomaintain activated dermal dendrocytes.

There are 3 million patients in the United States afflicted withpsoriasis. The available treatments for psoriasis are corticosteroids.The most widely prescribed are TEMOVATE (clobetasol propionate), LIDEX(fluocinonide), DIPROLENE (betamethasone propionate), PSORCON(diflorasone diacetate) and TRIAMCINOLONE formulated for topicalapplication. The mechanism of action of corticosteroids ismultifactorial. This is a palliative therapy because the underlyingcause of the disease remains, and upon discontinuation of the treatmentthe disease returns. Discontinuation of treatment is often prompted bythe appearance of adverse effects such as atrophy, telangiectasias andpurpura. Corticosteroids are not recommended for prolonged treatments orwhen treatment of large and/or inflamed areas is required. Alternativetreatments include retinoids, such as etretinate, which has beenapproved for treatment of severe, refractory psoriasis. Alternativeretinoid-based treatments are in advanced clinical trials. Retinoids actby converting keratinocytes to a differentiated state and restoration ofnormal skin development. Immunosuppressive drugs such as cyclosporineare also in the advanced stages of clinical trials. Due to thenonspecific mechanism of action of corticosteroids, retinoids andimmunosuppressives, these treatments exhibit severe side effects andshould not be used for extended periods of time unless the condition islife-threatening or disabling. There is a need for a less toxic,effective therapeutic agent in psoriatic patients.

HIV and AIDS

The human immunodeficiency virus (HIV) causes several fundamentalchanges in the human immune system from the time of infection until thedevelopment of full-blown acquired immunodeficiency syndrome (AIDS).These changes include a shift in the ratio of CD4+ to CD8+ T-cells,sustained elevation of IL-4 levels, episodic elevation of TNF-α andTNF-β levels, hypergammaglobulinemia, and lymphoma/leukemia (Rosenberg &Fauci, 1990 Immun. Today 11, 176; Weiss 1993 Science 260, 1273). Manypatients experience a unique tumor, Kaposi's sarcoma and/or unusualopportunistic infections (e.g. Pneumocystis carinii, cytomegalovirus,herpesviruses, hepatitis viruses, papilloma viruses, and tuberculosis).The immunological dysfunction of individuals with AIDS suggests thatsome of the pathology may be due to cytokine dysregulation.

Levels of serum TNF-α and IL-6 are often found to be elevated in AIDSpatients (Weiss, 1993 supra). In tissue culture, HIV infection ofmonocytes isolated from healthy individuals stimulates secretion of bothTNF-α and IL-6. This response has been reproduced using purified gp120,the viral coat protein responsible for binding to CD-4 (Buonaguro etal., 1992 J. Virol. 66, 7159). It has also been demonstrated that theviral gene regulator, Tat, can directly induce TNF transcription. Theability of HIV to directly stimulate secretion of TNF-α and IL-6 may bean adaptive mechanism of the virus. TNF-α has been shown to upregulatetranscription of the LTR of HIV, increasing the number of HIV-specifictranscripts in infected cells. IL-6 enhances HIV production, but at apost-transcriptional level, apparently increasing the efficiency withwhich HIV transcripts are translated into protein. Thus, stimulation ofTNF-α secretion by the HIV virus may promote infection of neighboringCD4+ cells both by enhancing virus production from latently infectedcells and by driving replication of the virus in newly infected cells.

The role of TNF-α in HIV replication has been well established in tissueculture models of infection (Sher et al., 1992 Immun. Rev. 127, 183),suggesting that the mutual induction of HIV replication and TNF-αreplication may create positive feedback in vivo. However, evidence forthe presence of such positive feedback in infected patients is notabundant. TNF-α levels are found to be elevated in some, but not allpatients tested. Children with AIDS who were given zidovudine hadreduced levels of TNF-α compared to those not given zidovudine (Cremoniet al., 1993 AIDS 7, 128). This correlation lends support to thehypothesis that reduced viral replication is physiologically linked toTNF-α levels. Furthermore, recently it has been shown that thepolyclonal B cell activation associated with HIV infection is due tomembrane-bound TNF-α. Thus, levels of secreted TNF-α may not accuratelyreflect the contribution of this cytokine to AIDS pathogenesis.

Chronic elevation of TNF-α has been shown to shown to result in cachexia(Tracey et al., 1992 Am. J. Trop. Med. Hyg. 47, 2-7), increasedautoimmune disease (Jacob, 1992 supra), lethargy, and immune suppressionin animal models (Aderka et al., 1992 Isr. J. Med. Sci. 28, 126-130).The cachexia associated with AIDS may be associated with chronicallyelevated TNF-α frequently observed in AIDS patients. Similarly, TNF-αcan stimulate the proliferation of spindle cells isolated from Kaposi'ssarcoma lesions of AIDS patients (Barillari et al., 1992 J Immunol 149,3727).

A therapeutic agent that inhibits cytokine gene expression, inhibitsadhesion molecule expression, and mimics the anti-inflammatory effectsof glucocorticoids (without inducing steroid-responsive genes) is idealfor the treatment of inflammatory and autoimmune disorders. Diseasetargets for such a drug are numerous. Target indications and thedelivery options each entails are summarized below. In all cases,because of the potential immunosuppressive properties of a ribozyme thatcleaves the specified sites in TNF-α mRNA, uses are limited to localdelivery, acute indications, or ex vivo treatment.

•Septic shock.

Exogenous delivery of ribozymes to macrophages can be achieved byintraperitoneal or intravenous injections. Ribozymes will be deliveredby incorporation into liposomes or by complexing with cationic lipids.

•Rheumatoid arthritis (RA).

Due to the chronic nature of RA, a gene therapy approach is logical.Delivery of a ribozyme to inflamed joints is mediated by adenovirus,retrovirus, or adeno-associated virus vectors. For instance, theappropriate adenovirus vector can be administered by direct injectioninto the synovium: high efficiency of gene transfer and expression forseveral months would be expected (B. J. Roessler, E. D. Allen, J. M.Wilson, J. W. Hartman, B. L. Davidson, J. Clin. Invest. 92, 1085-1092(1993)). It is unlikely that the course of the disease could be reversedby the transient, local administration of an anti-inflammatory agent.Multiple administrations may be necessary. Retrovirus andadeno-associated virus vectors would lead to permanent gene transfer andexpression in the joint. However, permanent expression of a potentanti-inflammatory agent may lead to local immune deficiency.

•Psoriasis

The psoriatic plaque is a particularly good candidate for ribozyme orvector delivery. The stratum corneum of the plaque is thinned, providingaccess to the proliferating keratinocytes. T-cells and dermaldendrocytes can be efficiently targeted by trans-epidermal diffusion.

Organ culture systems for biopsy specimens of psoriatic and normal skinare described in current literature (Nickoloff et al., 1993 Supra).Primary human keratinocytes are easily obtained and will be grown intoepidermal sheets in tissue culture. In addition to these tissue culturemodels, the flaky skin mouse develops psoriatic skin in response to UVlight. This model would allow demonstration of animal efficacy forribozyme treatments of psoriasis.

•Gene Therapy.

Immune responses limit the efficacy of many gene transfer techniques.Cells transfected with retrovirus vectors have short lifetimes in immunecompetent individuals. The length of expression of adenovirus vectors interminally differentiated cells is longer in neonatal orimmune-compromised animals. Insertion of a small ribozyme expressioncassette that modulates inflammatory and immune responses into existingadenovirus or retrovirus constructs will greatly enhance theirpotential.

Thus, ribozymes of the present invention that cleave TNF-α mRNA andthereby TNF-α activity have many potential therapeutic uses, and thereare reasonable modes of delivering the ribozymes in a number of thepossible indications. Development of an effective ribozyme that inhibitsTNF-α function is described above; available cellular and activityassays are number, reproducible, and accurate. Animal models for TNF-αfunction and for each of the suggested disease targets exist and can beused to optimize activity.

Diagnostic uses

Ribozymes of this invention may be used as diagnostic tools to examinegenetic drift and mutations within diseased cells. The closerelationship between ribozyme activity and the structure of the targetRNA allows the detection of mutations in any region of the moleculewhich alters the base-pairing and three-dimensional structure of thetarget RNA. By using multiple ribozymes described in this invention, onemay map nucleotide changes which are important to RNA structure andfunction in vitro, as well as in cells and tissues. Cleavage of targetRNAs with ribozymes may be used to inhibit gene expression and definethe role (essentially) of specified gene products in the progression ofdisease. In this manner, other genetic targets may be defined asimportant mediators of the disease. These experiments will lead tobetter treatment of the disease progression by affording the possibilityof combinational therapies (e.g., multiple ribozymes targeted todifferent genes, ribozymes coupled with known small molecule inhibitors,or intermittent treatment with combinations of ribozymes and/or otherchemical or biological molecules). Other in vitro uses of ribozymes ofthis invention are well known in the art, and include detection of thepresence of mRNA associated with a TNF-α related condition. Such RNA isdetected by determining the presence of a cleavage product aftertreatment with a ribozyme using standard methodology.

In a specific example, ribozymes which can cleave only wild-type ormutant forms of the target RNA are used for the assay. The firstribozyme is used to identify wild-type RNA present in the sample and thesecond ribozyme will be used to identify mutant RNA in the sample. Asreaction controls, synthetic substrates of both wild-type and mutant RNAwill be cleaved by both ribozymes to demonstrate the relative ribozymeefficiencies in the reactions and the absence of cleavage of the"non-targeted" RNA species. The cleavage products from the syntheticsubstrates will also serve to generate size markers for the analysis ofwild-type and mutant RNAs in the sample population. Thus each analysiswill require two ribozymes, two substrates and one unknown sample whichwill be combined into six reactions. The presence of cleavage productswill be determined using an RNAse protection assay so that full-lengthand cleavage fragments of each RNA can be analyzed in one lane of apolyacrylamide gel. It is not absolutely required to quantify theresults to gain insight into the expression of mutant RNAs and putativerisk of the desired phenotypic changes in target cells. The expressionof mRNA whose protein product is implicated in the development of thephenotype (i.e., TNF-α) is adequate to establish risk. If probes ofcomparable specific activity are used for both transcripts, then aqualitative comparison of RNA levels will be adequate and will decreasethe cost of the initial diagnosis. Higher mutant form to wild-typeratios will be correlated with higher risk whether RNA levels arecompared qualitatively or quantitatively.

A number of other cytokines may also be involved in the activation ofinflammation, including platelet activating factor, IL-1, IL-3, IL-4,GM-CSF, gamma interferon, ILAM-1, ELAM-1 and EoCSF. In addition to thesecytokines, it is appreciated that any cellular receptors which mediatethe activities of the cytokines are also good targets for interventionin inflammatory diseases. These targets include, but are not limited to,the IL-1R and TNF-αR on keratinocytes, epithelial and endothelial cellsin airways. Recent data suggest that certain neuropeptides may play arole in asthmatic symptoms. These peptides include substance P,neurokinin A and calcitonin-gene-related peptides. These target genesmay have more general roles in inflammatory diseases, but are currentlyassumed to have a role only in asthma. Other genes which are consideredto play a role in asthma are the c-myb and c-myc genes, which may betriggered to induce endothelial cell proliferation and contribute toblockage of the airways. Those skilled in the art will recognize theother potential targets noted above are also suitable for treatment withribozymes, which will reduce the risk or occurrence of inflammatorydisease, such as the interleukins (1, 3, 4, 6, and 8), glyceroltransferase, selectins (E-selectin, MEL-14), cell adhesion molecules(ICAM-1, ELAM-1, VCAM-1, GMP-140, MAM), IL-1R, TGFβ R, EoCSF,α-, β- orγ-interferon, EoCSF, GM-CSF and protein kinase C (PKC)

Other embodiments are within the following claims.

TABLE I Characteristics of Ribozymes

Group I Introns Size: ˜200 to >1000 nucleotides. Requires a U in thetarget sequence immediately 5' of the cleavage site. Binds 4-6nucleotides at 5' side of cleavage site. Over 75 known members of thisclass. Found in Tetrahymena thermophila rRNA, fungal mitochondria,chloroplasts, phage T4, blue-green algae, and others.

RNAseP RNA (M1 RNA) Size: ˜290 to 400 nucleotides. RNA portion of aribonucleoprotein enzyme. Cleaves tRNA precursors to form mature tRNA.Roughly 10 known members of this group all are bacterial in origin.

Hammerhead Ribozyme Size: ˜13 to 40 nucleotides. Requires the targetsequence UH immediately 5' of the cleavage site. Binds a variable numbernucleotides on both sides of the cleavage site. 14 known members of thisclass. Found in a number of plant pathogens (virusoids) that use RNA asthe infectious agent (FIGS. 1 and 2)

Hairpin Ribozyme Size: ˜50 nucleotides. Requires the target sequence GUCimmediately 3' of the cleavage site. Binds 4-6 nucleotides at 5' side ofthe cleavage site and a variable number to the 3' side of the cleavagesite. Only 3 known member of this class. Found in three plant pathogen(satellite RNAs of the tobacco ringspot virus, arabis mosaic virus andchicory yellow mottle virus) which uses RNA as the infectious agent(FIG. 3).

Hepatitis Delta Virus (HDV) Ribozyme Size: 50-60 nucleotides (atpresent). Cleavage of target RNAs recently demonstrated. Sequencerequirements not fully determined. Binding sites and structuralrequirements not fully determined, although no sequences 5' of cleavagesite are required. Only 1 known member of this class. Found in human HDV(FIG. 4).

Neurospora VS RNA Ribozyme Size: ˜144 nucleotides (at present) Cleavageof target RNAs recently demonstrated. Sequence requirements not fullydetermined. Binding sites and structural requirements not fullydetermined. Only 1 known member of this class. Found in Neurospora VSRNA (FIG. 5).

                                      TABLE II                                    __________________________________________________________________________    Human TNF-a HH Ribozyme Target Sequence                                       nt.             Sequence                                                                           nt.             Sequence                                 Position                                                                          HH Target Sequence                                                                        ID No.                                                                             Position                                                                          HH Target Sequence                                                                        ID No.                                   __________________________________________________________________________     28 GGCAGGU U CUCUUCC                                                                          15                                                            29 GCAGGUU C UCUUCCU                                                                          16   321                                                                              GUCAGAU C AUCUUCU                                                                          54                                       31 AGGUUCU C UUCCUCU                                                                          17   324                                                                              AGAUCAU C UUCUCGA                                                                          55                                       33 GUUCUCU U CCUCUCA                                                                          18   326                                                                              AUCAUCU U CUCGAAC                                                                          56                                       34 UUCUCUU C CUCUCAC                                                                          19   327                                                                              UCAUCUU C UCGAACC                                                                          57                                       37 UCUUCCU C UCACAUA                                                                          20   329                                                                              AUCUUCU C GAACCCC                                                                          58                                       39 UUCCUCU C ACAUACU                                                                          21   352                                                                              AGCCUGU A GCCCAUG                                                                          59                                       44 CUCACAU A CUGACCC                                                                          22   361                                                                              CCCAUGU U GUAGCAA                                                                          60                                       58 CACGGCU C CACCCUC                                                                          23   364                                                                              AUGUUGU A GCAAACC                                                                          61                                       65 CCACCCU C UCUCCCC                                                                          24   374                                                                              AAACCCU C AAGCUGA                                                                          62                                       67 ACCCUCU C UCCCCUG                                                                          25   391                                                                              GGCAGCU C CAGUGGC                                                                          63                                       69 CCUCUCU C CCCUGGA                                                                          26   421                                                                              AUGCCCU C CUGGCCA                                                                          64                                       106                                                                              GCAUGAU C CGGGACG                                                                          27   449                                                                              GAGAGAU A ACCAGCU                                                                          65                                       136                                                                              AGGCGCU C CCCAAGA                                                                          28   468                                                                              GUGCCAU C AGAGGGC                                                                          66                                       165                                                                              CAGGGCU C CAGGCGG                                                                          29   480                                                                              GGCCUGU A CCUCAUC                                                                          67                                       177                                                                              CGGUGCU U GUUCCUC                                                                          30   484                                                                              UGUACCU C AUCUACU                                                                          68                                       180                                                                              UGCUUGU U CCUCAGC                                                                          31   487                                                                              ACCUCAU C UACUCCC                                                                          69                                       181                                                                              GCUUGUU C CUCAGCC                                                                          32   489                                                                              CUCAUCU A CUCCCAG                                                                          70                                       184                                                                              UGUUCCU C AGCCUCU                                                                          33   492                                                                              AUCUACU C CCAGGUC                                                                          71                                       190                                                                              UCAGCCU C UUCUCCU                                                                          34   499                                                                              CCCAGGU C CUCUUCA                                                                          72                                       192                                                                              AGCCUCU U CUCCUUC                                                                          35   502                                                                              AGGUCCU C UUCAAGG                                                                          73                                       193                                                                              GCCUCUU C UCCUUCC                                                                          36   504                                                                              GUCCUCU U CAAGGGC                                                                          74                                       195                                                                              CUCUUCU C CUUCCUG                                                                          37   505                                                                              UCCUCUU C AAGGGCC                                                                          75                                       198                                                                              UUCUCCU U CCUGAUC                                                                          38   525                                                                              UGCCCCU C CACCCAU                                                                          76                                       199                                                                              UCUCCUU C CUGAUCG                                                                          39   538                                                                              AUGUGCU C CUCACCC                                                                          77                                       205                                                                              UCCUGAU C GUGGCAG                                                                          40   541                                                                              UGCUCCU C ACCCACA                                                                          78                                       226                                                                              CCACGCU C UUCUGCC                                                                          41   553                                                                              ACACCAU C AGCCGCA                                                                          79                                       228                                                                              ACGCUCU U CUGCCUG                                                                          42   562                                                                              GCCGCAU C GCCGUCU                                                                          80                                       229                                                                              CGCUCUU C UGCCUGC                                                                          43   568                                                                              UCGCCGU C UCCUACC                                                                          81                                       243                                                                              CUGCACU U UGGAGUG                                                                          44   570                                                                              GCCGUCU C CUACCAG                                                                          82                                       244                                                                              UGCACUU U GGAGUGA                                                                          45   573                                                                              GUCUCCU A CCAGACC                                                                          83                                       253                                                                              GAGUGAU C GGCCCCC                                                                          46   586                                                                              CCAAGGU C AACCUCC                                                                          84                                       273                                                                              GAAGAGU C CCCCAGG                                                                          47   592                                                                              UCAACCU C CUCUCUG                                                                          85                                       286                                                                              GGGACCU C UCUCUAA                                                                          48   595                                                                              ACCUCCU C UCUGCCA                                                                          86                                       288                                                                              GACCUCU C UCUAAUC                                                                          49   597                                                                              CUCCUCU C UGCCAUC                                                                          87                                       290                                                                              CCUCUCU C UAAUCAG                                                                          50   604                                                                              CUGCCAU C AAGAGCC                                                                          88                                       292                                                                              UCUCUCU A AUCAGCC                                                                          51   657                                                                              CCCUGGU A UGAGCCC                                                                          89                                       295                                                                              CUCUAAU C AGCCCUC                                                                          52   667                                                                              AGCCCAU C UAUCUGG                                                                          90                                       302                                                                              CAGCCCU C UGGCCCA                                                                          53   669                                                                              CCCAUCU A UCUGGGA                                                                          91                                       671                                                                              CAUCUAU C UGGGAGG                                                                          92   960                                                                              UGGGAUU C AGGAAUG                                                                         141                                       682                                                                              GAGGGGU C UUCCAGC                                                                          93  1001                                                                              AACCACU A AGAAUUC                                                                         142                                       684                                                                              GGGGUCU U CCAGCUG                                                                          94  1007                                                                              UAAGAAU U CAAACUG                                                                         143                                       685                                                                              GGGUCUU C CAGCUGG                                                                          95  1008                                                                              AAGAAUU C AAACUGG                                                                         144                                       709                                                                              ACCGACU C AGCGCUG                                                                          96  1021                                                                              GGGGCCU C CAGAACU                                                                         145                                       721                                                                              CUGAGAU C AAUCGGC                                                                          97  1029                                                                              CAGAACU C ACUGGGG                                                                         146                                       725                                                                              GAUCAAU C GGCCCGA                                                                          98  1040                                                                              GGGGCCU A CAGCUUU                                                                         147                                       735                                                                              CCCGACU A UCUCGAC                                                                          99  1046                                                                              UACAGCU U UGAUCCC                                                                         148                                       737                                                                              CGACUAU C UCGACUU                                                                         100  1047                                                                              ACAGCUU U GAUCCCU                                                                         149                                       739                                                                              ACUAUCU C GACUUUG                                                                         101  1051                                                                              CUUUGAU C CCUGACA                                                                         150                                       744                                                                              CUCGACU U UGCCGAG                                                                         102  1060                                                                              CUGACAU C UGGAAUC                                                                         151                                       745                                                                              UCGACUU U GCCGAGU                                                                         103  1067                                                                              CUGGAAU C UGGAGAC                                                                         152                                       753                                                                              GCCGAGU C UGGGCAG                                                                         104  1085                                                                              GGAGCCU U UGGUUCU                                                                         153                                       763                                                                              GGCAGGU C UACUUUG                                                                         105  1086                                                                              GAGCCUU U GGUUCUG                                                                         154                                       765                                                                              CAGGUCU A CUUUGGG                                                                         106  1090                                                                              CUUUGGU U CUGGCCA                                                                         155                                       768                                                                              GUCUACU U UGGGAUC                                                                         107  1091                                                                              UUUGGUU C UGGCCAG                                                                         156                                       769                                                                              UCUACUU U GGGAUCA                                                                         108  1113                                                                              CAGGACU U GAGAAGA                                                                         157                                       775                                                                              UUGGGAU C AUUGCCC                                                                         109  1124                                                                              AAGACCU C ACCUAGA                                                                         158                                       778                                                                              GGAUCAU U GCCCUGU                                                                         110  1129                                                                              CUCACCU A GAAAUUG                                                                         159                                       801                                                                              CGAACAU C CAACCUU                                                                         111  1135                                                                              UAGAAAU U GACACAA                                                                         160                                       808                                                                              CCAACCU U CCCAAAC                                                                         112  1151                                                                              UGGACCU U AGGCCUU                                                                         161                                       809                                                                              CAACCUU C CCAAACG                                                                         113  1152                                                                              GGACCUU A GGCCUUC                                                                         162                                       820                                                                              AACGCCU C CCCUGCC                                                                         114  1158                                                                              UAGGCCU U CCUCUCU                                                                         163                                       833                                                                              CCCCAAU C CCUUUAU                                                                         115  1159                                                                              AGGCCUU C CUCUCUC                                                                         164                                       837                                                                              AAUCCCU U UAUUACC                                                                         116  1162                                                                              CCUUCCU C UCUCCAG                                                                         165                                       838                                                                              AUCCCUU U AUUACCC                                                                         117  1164                                                                              UUCCUCU C UCCAGAU                                                                         166                                       839                                                                              UCCCUUU A UUACCCC                                                                         118  1166                                                                              CCUCUCU C CAGAUGU                                                                         167                                       841                                                                              CCUUUAU U ACCCCCU                                                                         119  1174                                                                              CAGAUGU U UCCAGAC                                                                         168                                       842                                                                              CUUUAUU A CCCCCUC                                                                         120  1175                                                                              AGAUGUU U CCAGACU                                                                         169                                       849                                                                              ACCCCCU C CUUCAGA                                                                         121  1176                                                                              GAUGUUU C CAGACUU                                                                         170                                       852                                                                              CCCUCCU U CAGACAC                                                                         122  1183                                                                              CCAGACU U CCUUGAG                                                                         171                                       853                                                                              CCUCCUU C AGACACC                                                                         123  1184                                                                              CAGACUU C CUUGAGA                                                                         172                                       863                                                                              ACACCCU C AACCUCU                                                                         124  1187                                                                              ACUUCCU U GAGACAC                                                                         173                                       869                                                                              UCAACCU C UUCUGGC                                                                         125  1208                                                                              CAGCCCU C CCCAUGG                                                                         174                                       871                                                                              AACCUCU U CUGGCUC                                                                         126  1224                                                                              GCCAGCU C CCUCUAU                                                                         175                                       872                                                                              ACCUCUU C UGGCUCA                                                                         127  1228                                                                              GCUCCCU C UAUUUAU                                                                         176                                       878                                                                              UCUGGCU C AAAAAGA                                                                         128  1230                                                                              UCCCUCU A UUUAUGU                                                                         177                                       890                                                                              AGAGAAU U GGGGGCU                                                                         129  1232                                                                              CCUCUAU U UAUGUUU                                                                         178                                       898                                                                              GGGGGCU U AGGGUCG                                                                         130  1233                                                                              CUCUAUU U AUGUUUG                                                                         179                                       899                                                                              GGGGCUU A GGGUCGG                                                                         131  1234                                                                              UCUAUUU A UGUUUGC                                                                         180                                       904                                                                              UUAGGGU C GGAACCC                                                                         132  1238                                                                              UUUAUGU U UGCACUU                                                                         181                                       917                                                                              CCAAGCU U AGAACUU                                                                         133  1239                                                                              UUAUGUU U GCACUUG                                                                         182                                       918                                                                              CAAGCUU A GAACUUU                                                                         134  1245                                                                              UUGCACU U GUGAUUA                                                                         183                                       924                                                                              UAGAACU U UAAGCAA                                                                         135  1251                                                                              UUGUGAU U AUUUAUU                                                                         184                                       925                                                                              AGAACUU U AAGCAAC                                                                         136  1252                                                                              UGUGAUU A UUUAUUA                                                                         185                                       926                                                                              GAACUUU A AGCAACA                                                                         137  1254                                                                              UGAUUAU U UAUUAUU                                                                         186                                       945                                                                              CACCACU U CGAAACC                                                                         138  1255                                                                              GAUUAUU U AUUAUUU                                                                         187                                       946                                                                              ACCACUU C GAAACCU                                                                         139  1256                                                                              AUUAUUU A UUAUUUA                                                                         188                                       959                                                                              CUGGGAU U CAGGAAU                                                                         140  1258                                                                              UAUUUAU U AUUUAUU                                                                         189                                      1259                                                                              AUUUAUU A UUUAUUU                                                                         190  1440                                                                              UGUUUUU U AAAAUAU                                                                         238                                      1261                                                                              UUAUUAU U UAUUUAU                                                                         191  1441                                                                              GUUUUUU A AAAUAUU                                                                         239                                      1262                                                                              UAUUAUU U AUUUAUU                                                                         192  1446                                                                              UUAAAAU A UUAUCUG                                                                         240                                      1263                                                                              AUUAUUU A UUUAUUA                                                                         193  1448                                                                              AAAAUAU U AUCUGAU                                                                         241                                      1265                                                                              UAUUUAU U UAUUAUU                                                                         194  1449                                                                              AAAUAUU A UCUGAUU                                                                         242                                      1266                                                                              AUUUAUU U AUUAUUU                                                                         195  1451                                                                              AUAUUAU C UGAUUAA                                                                         243                                      1267                                                                              UUUAUUU A UUAUUUA                                                                         196  1456                                                                              AUCUGAU U AAGUUGU                                                                         244                                      1269                                                                              UAUUUAU U AUUUAUU                                                                         197  1457                                                                              UCUGAUU A AGUUGUC                                                                         245                                      1270                                                                              AUUUAUU A UUUAUUU                                                                         198  1461                                                                              AUUAAGU U GUCUAAA                                                                         246                                      1272                                                                              UUAUUAU U UAUUUAU                                                                         199  1464                                                                              AAGUUGU C UAAACAA                                                                         247                                      1273                                                                              UAUUAUU U AUUUAUU                                                                         200  1466                                                                              GUUGUCU A AACAAUG                                                                         248                                      1274                                                                              AUUAUUU A UUUAUUU                                                                         201  1479                                                                              UGCUGAU U UGGUGAC                                                                         249                                      1276                                                                              UAUUUAU U UAUUUAC                                                                         202  1480                                                                              GCUGAUU U GGUGACC                                                                         250                                      1277                                                                              AUUUAUU U AUUUACA                                                                         203  1494                                                                              CAACUGU C ACUCAUU                                                                         251                                      1278                                                                              UUUAUUU A UUUACAG                                                                         204  1498                                                                              UGUCACU C AUUGCUG                                                                         252                                      1280                                                                              UAUUUAU U UACAGAU                                                                         205  1501                                                                              CACUCAU U GCUGAGG                                                                         253                                      1281                                                                              AUUUAUU U ACAGAUG                                                                         206  1512                                                                              GAGGCCU C UGCUCCC                                                                         254                                      1282                                                                              UUUAUUU A CAGAUGA                                                                         207  1517                                                                              CUCUGCU C CCCAGGG                                                                         255                                      1294                                                                              UGAAUGU A UUUAUUU                                                                         208  1528                                                                              AGGGAGU U GUGUCUG                                                                         256                                      1296                                                                              AAUGUAU U UAUUUGG                                                                         209  1533                                                                              GUUGUGU C UGUAAUC                                                                         257                                      1297                                                                              AUGUAUU U AUUUGGG                                                                         210  1537                                                                              UGUCUGU A AUCGGCC                                                                         258                                      1298                                                                              UGUAUUU A UUUGGGA                                                                         211  1540                                                                              CUGUAAU C GGCCUAC                                                                         259                                      1300                                                                              UAUUUAU U UGGGAGA                                                                         212  1546                                                                              UCGGCCU A CUAUUCA                                                                         260                                      1301                                                                              AUUUAUU U GGGAGAC                                                                         213  1549                                                                              GCCUACU A UUCAGUG                                                                         261                                      1315                                                                              CCGGGGU A UCCUGGG                                                                         214  1551                                                                              CUACUAU U CAGUGGC                                                                         262                                      1317                                                                              GGGGUAU C CUGGGGG                                                                         215  1552                                                                              UACUAUU C AGUGGCG                                                                         263                                      1334                                                                              CCAAUGU A GGAGCUG                                                                         216  1566                                                                              GAGAAAU A AAGGUUG                                                                         264                                      1345                                                                              GCUGCCU U GGCUCAG                                                                         217  1572                                                                              UAAAGGU U GCUUAGG                                                                         265                                      1350                                                                              CUUGGCU C AGACAUG                                                                         218  1576                                                                              GGUUGCU U AGGAAAG                                                                         266                                      1359                                                                              GACAUGU U UUCCGUG                                                                         219  1577                                                                              GUUGCUU A GGAAAGA                                                                         267                                      1360                                                                              ACAUGUU U UCCGUGA                                                                         220                                                           1361                                                                              CAUGUUU U CCGUGAA                                                                         221                                                           1362                                                                              AUGUUUU C CGUGAAA                                                                         222                                                           1386                                                                              GAACAAU A GGCUGUU                                                                         223                                                           1393                                                                              AGGCUGU U CCCAUGU                                                                         224                                                           1394                                                                              GGCUGUU C CCAUGUA                                                                         225                                                           1401                                                                              CCCAUGU A GCCCCCU                                                                         226                                                           1414                                                                              CUGGCCU C UGUGCCU                                                                         227                                                           1422                                                                              UGUGCCU U CUUUUGA                                                                         228                                                           1423                                                                              GUGCCUU C UUUUGAU                                                                         229                                                           1425                                                                              GCCUUCU U UUGAUUA                                                                         230                                                           1426                                                                              CCUUCUU U UGAUUAU                                                                         231                                                           1427                                                                              CUUCUUU U GAUUAUG                                                                         232                                                           1431                                                                              UUUUGAU U AUGUUUU                                                                         233                                                           1432                                                                              UUUGAUU A UGUUUUU                                                                         234                                                           1436                                                                              AUUAUGU U UUUUAAA                                                                         235                                                           1437                                                                              UUAUGUU U UUUAAAA                                                                         236                                                           1438                                                                              UAUGUUU U UUAAAAU                                                                         237                                                           __________________________________________________________________________

                                      TABLE III                                   __________________________________________________________________________    Human TNF-a Hammerhead Ribozyme Sequences                                     nt.                             Sequence                                      Position                                                                           HH Ribozyme Sequence       ID No.                                        __________________________________________________________________________     28  GGAAGAG CUGAUGAGGCCGAAAGGCCGAA ACCUGCC                                                                   268                                            29  AGGAAGA CUGAUGAGGCCGAAAGGCCGAA AACCUGC                                                                   269                                            31  AGAGGAA CUGAUGAGGCCGAAAGGCCGAA AGAACCU                                                                   270                                            33  UGAGAGG CUGAUGAGGCCGAAAGGCCGAA AGAGAAC                                                                   271                                            34  GUGAGAG CUGAUGAGGCCGAAAGGCCGAA AAGAGAA                                                                   271                                            37  UAUGUGA CUGAUGAGGCCGAAAGGCCGAA AGGAAGA                                                                   273                                            39  AGUAUGU CUGAUGAGGCCGAAAGGCCGAA AGAGGAA                                                                   274                                            44  GGGUCAG CUGAUGAGGCCGAAAGGCCGAA AUGUGAG                                                                   275                                            58  GAGGGUG CUGAUGAGGCCGAAAGGCCGAA AGCCGUG                                                                   276                                            65  GGGGAGA CUGAUGAGGCCGAAAGGCCGAA AGGGUGG                                                                   277                                            67  CAGGGGA CUGAUGAGGCCGAAAGGCCGAA AGAGGGU                                                                   278                                            69  UCCAGGG CUGAUGAGGCCGAAAGGCCGAA AGAGAGG                                                                   279                                            106 CGUCCCG CUGAUGAGGCCGAAAGGCCGAA AUCAUGC                                                                   280                                            136 UCUUGGG CUGAUGAGGCCGAAAGGCCGAA AGCGCCU                                                                   281                                            165 CCGCCUG CUGAUGAGGCCGAAAGGCCGAA AGCCCUG                                                                   282                                            177 GAGGAAC CUGAUGAGGCCGAAAGGCCGAA AGCACCG                                                                   283                                            180 GCUGAGG CUGAUGAGGCCGAAAGGCCGAA ACAAGCA                                                                   284                                            181 GGCUGAG CUGAUGAGGCCGAAAGGCCGAA AACAAGC                                                                   285                                            184 AGAGGCU CUGAUGAGGCCGAAAGGCCGAA AGGAACA                                                                   286                                            190 AGGAGAA CUGAUGAGGCCGAAAGGCCGAA AGGCUGA                                                                   287                                            192 GAAGGAG CUGAUGAGGCCGAAAGGCCGAA AGAGGCU                                                                   288                                            193 GGAAGGA CUGAUGAGGCCGAAAGGCCGAA AAGAGGC                                                                   289                                            195 CAGGAAG CUGAUGAGGCCGAAAGGCCGAA AGAAGAG                                                                   290                                            198 GAUCAGG CUGAUGAGGCCGAAAGGCCGAA AGGAGAA                                                                   291                                            199 CGAUCAG CUGAUGAGGCCGAAAGGCCGAA AAGGAGA                                                                   292                                            205 CUGCCAC CUGAUGAGGCCGAAAGGCCGAA AUCAGGA                                                                   293                                            226 GCCAGAA CUGAUGAGGCCGAAAGGCCGAA AGCGUGG                                                                   294                                            228 CAGGCAG CUGAUGAGGCCGAAAGGCCGAA AGAGCGU                                                                   295                                            229 GCAGGCA CUGAUGAGGCCGAAAGGCCGAA AAGAGCG                                                                   296                                            243 CACUCCA CUGAUGAGGCCGAAAGGCCGAA AGUGCAG                                                                   297                                            244 UCACUCC CUGAUGAGGCCGAAAGGCCGAA AAGUGCA                                                                   298                                            253 GGGGGCC CUGAUGAGGCCGAAAGGCCGAA AUCACUC                                                                   299                                            273 CCUGGGG CUGAUGAGGCCGAAAGGCCGAA ACUCUUC                                                                   300                                            286 UUAGAGA CUGAUGAGGCCGAAAGGCCGAA AGGUCCC                                                                   301                                            288 GAUUAGA CUGAUGAGGCCGAAAGGCCGAA AGAGGUC                                                                   302                                            290 CUGAUUA CUGAUGAGGCCGAAAGGCCGAA AGAGAGG                                                                   303                                            292 GGCUGAU CUGAUGAGGCCGAAAGGCCGAA AGAGAGA                                                                   304                                            295 GAGGGCU CUGAUGAGGCCGAAAGGCCGAA AUUAGAG                                                                   305                                            302 UGGGCCA CUGAUGAGGCCGAAAGGCCGAA AGGGCUG                                                                   306                                            321 AGAAGAU CUGAUGAGGCCGAAAGGCCGAA AUCUGAC                                                                   307                                            324 UCGAGAA CUGAUGAGGCCGAAAGGCCGAA AUGAUCU                                                                   308                                            326 GUUCGAG CUGAUGAGGCCGAAAGGCCGAA AGAUGAU                                                                   309                                            327 GGUUCGA CUGAUGAGGCCGAAAGGCCGAA AAGAUGA                                                                   310                                            329 GGGGUUC CUGAUGAGGCCGAAAGGCCGAA AGAAGAU                                                                   311                                            352 CAUGGGC CUGAUGAGGCCGAAAGGCCGAA ACAGGCU                                                                   312                                            361 UUGCUAC CUGAUGAGGCCGAAAGGCCGAA ACAUGGG                                                                   313                                            364 GGUUUGC CUGAUGAGGCCGAAAGGCCGAA ACAACAU                                                                   314                                            374 UCAGCUU CUGAUGAGGCCGAAAGGCCGAA AGGGUUU                                                                   315                                            391 GCCACUG CUGAUGAGGCCGAAAGGCCGAA AGCUGCC                                                                   316                                            421 UGGCCAG CUGAUGAGGCCGAAAGGCCGAA AGGGCAU                                                                   317                                            449 AGCUGGU CUGAUGAGGCCGAAAGGCCGAA AUCUCUC                                                                   318                                            468 GCCCUCU CUGAUGAGGCCGAAAGGCCGAA AUGGCAC                                                                   319                                            480 GAUGAGG CUGAUGAGGCCGAAAGGCCGAA ACAGGCC                                                                   320                                            484 AGUAGAU CUGAUGAGGCCGAAAGGCCGAA AGGUACA                                                                   321                                            487 GGGAGUA CUGAUGAGGCCGAAAGGCCGAA AUGAGGU                                                                   322                                            489 CUGGGAG CUGAUGAGGCCGAAAGGCCGAA AGAUGAG                                                                   323                                            492 GACCUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGAU                                                                   324                                            499 UGAAGAG CUGAUGAGGCCGAAAGGCCGAA ACCUGGG                                                                   325                                            502 CCUUGAA CUGAUGAGGCCGAAAGGCCGAA AGGACCU                                                                   326                                            504 GCCCUUG CUGAUGAGGCCGAAAGGCCGAA AGAGGAC                                                                   327                                            505 GGCCCUU CUGAUGAGGCCGAAAGGCCGAA AAGAGGA                                                                   328                                            525 AUGGGUG CUGAUGAGGCCGAAAGGCCGAA AGGGGCA                                                                   329                                            538 GGGUGAG CUGAUGAGGCCGAAAGGCCGAA AGCACAU                                                                   330                                            541 UGUGGGU CUGAUGAGGCCGAAAGGCCGAA AGGAGCA                                                                   331                                            553 UGCCGCU CUGAUGAGGCCGAAAGGCCGAA AUGGUGU                                                                   332                                            562 AGACGGC CUGAUGAGGCCGAAAGGCCGAA AUGCGGC                                                                   333                                            568 GGUAGGA CUGAUGAGGCCGAAAGGCCGAA ACGGCGA                                                                   334                                            570 CUGGUAG CUGAUGAGGCCGAAAGGCCGAA AGACGGC                                                                   335                                            573 GGUCUGG CUGAUGAGGCCGAAAGGCCGAA AGGAGAC                                                                   336                                            586 GGAGGUU CUGAUGAGGCCGAAAGGCCGAA ACCUUGG                                                                   337                                            592 CAGAGAG CUGAUGAGGCCGAAAGGCCGAA AGGUUGA                                                                   338                                            595 UGGCAGA CUGAUGAGGCCGAAAGGCCGAA AGGAGGU                                                                   339                                            597 GAUGGCA CUGAUGAGGCCGAAAGGCCGAA AGAGGAG                                                                   340                                            604 GGCUCUU CUGAUGAGGCCGAAAGGCCGAA AUGGCAG                                                                   341                                            657 GGGCUCA CUGAUGAGGCCGAAAGGCCGAA ACCAGGG                                                                   342                                            667 CCAGAUA CUGAUGAGGCCGAAAGGCCGAA AUGGGCU                                                                   343                                            669 UCCCAGA CUGAUGAGGCCGAAAGGCCGAA AGAUGGG                                                                   344                                            671 CCUCCCA CUGAUGAGGCCGAAAGGCCGAA AUAGAUG                                                                   345                                            682 GCUGGAA CUGAUGAGGCCGAAAGGCCGAA ACCCCUC                                                                   346                                            684 CAGCUGG CUGAUGAGGCCGAAAGGCCGAA AGACCCC                                                                   347                                            685 CCAGCUG CUGAUGAGGCCGAAAGGCCGAA AAGACCC                                                                   348                                            709 CAGCGCU CUGAUGAGGCCGAAAGGCCGAA AGUCGGU                                                                   349                                            721 GCCGAUU CUGAUGAGGCCGAAAGGCCGAA AUCUCAG                                                                   350                                            725 UCGGGCC CUGAUGAGGCCGAAAGGCCGAA AUUGAUC                                                                   351                                            735 GUCGAGA CUGAUGAGGCCGAAAGGCCGAA AGUCGGG                                                                   352                                            737 AAGUCGA CUGAUGAGGCCGAAAGGCCGAA AUAGUCG                                                                   353                                            739 CAAAGUC CUGAUGAGGCCGAAAGGCCGAA AGAUAGU                                                                   354                                            744 CUCGGCA CUGAUGAGGCCGAAAGGCCGAA AGUCGAG                                                                   355                                            745 ACUCGGC CUGAUGAGGCCGAAAGGCCGAA AAGUCGA                                                                   356                                            753 CUGCCCA CUGAUGAGGCCGAAAGGCCGAA ACUCGGC                                                                   357                                            763 CAAAGUA CUGAUGAGGCCGAAAGGCCGAA ACCUGCC                                                                   358                                            765 CCCAAAG CUGAUGAGGCCGAAAGGCCGAA AGACCUG                                                                   359                                            768 GAUCCCA CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                   360                                            769 UGAUCCC CUGAUGAGGCCGAAAGGCCGAA AAGUAGA                                                                   361                                            775 GGGCAAU CUGAUGAGGCCGAAAGGCCGAA AUCCCAA                                                                   362                                            778 ACAGGGC CUGAUGAGGCCGAAAGGCCGAA AUGAUCC                                                                   363                                            801 AAGGUUG CUGAUGAGGCCGAAAGGCCGAA AUGUUCG                                                                   364                                            808 GUUUGGG CUGAUGAGGCCGAAAGGCCGAA AGGUUGG                                                                   365                                            809 CGUUUGG CUGAUGAGGCCGAAAGGCCGAA AAGGUUG                                                                   366                                            820 GGCAGGG CUGAUGAGGCCGAAAGGCCGAA AGGCGUU                                                                   367                                            833 AUAAAGG CUGAUGAGGCCGAAAGGCCGAA AUUGGGG                                                                   368                                            837 GGUAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGAUU                                                                   369                                            838 GGGUAAU CUGAUGAGGCCGAAAGGCCGAA AAGGGAU                                                                   370                                            839 GGGGUAA CUGAUGAGGCCGAAAGGCCGAA AAAGGGA                                                                   371                                            841 AGGGGGU CUGAUGAGGCCGAAAGGCCGAA AUAAAGG                                                                   372                                            842 GAGGGGG CUGAUGAGGCCGAAAGGCCGAA AAUAAAG                                                                   373                                            849 UCUGAAG CUGAUGAGGCCGAAAGGCCGAA AGGGGGU                                                                   374                                            852 GUGUCUG CUGAUGAGGCCGAAAGGCCGAA AGGAGGG                                                                   375                                            853 GGUGUCU CUGAUGAGGCCGAAAGGCCGAA AAGGAGG                                                                   376                                            863 AGAGGUU CUGAUGAGGCCGAAAGGCCGAA AGGGUGU                                                                   377                                            869 GCCAGAA CUGAUGAGGCCGAAAGGCCGAA AGGUUGA                                                                   378                                            871 GAGCCAG CUGAUGAGGCCGAAAGGCCGAA AGAGGUU                                                                   379                                            872 UGAGCCA CUGAUGAGGCCGAAAGGCCGAA AAGAGGU                                                                   380                                            878 UCUUUUU CUGAUGAGGCCGAAAGGCCGAA AGCCAGA                                                                   381                                            890 AGCCCCC CUGAUGAGGCCGAAAGGCCGAA AUUCUCU                                                                   382                                            898 CGACCCU CUGAUGAGGCCGAAAGGCCGAA AGCCCCC                                                                   383                                            899 CCGACCC CUGAUGAGGCCGAAAGGCCGAA AAGCCCC                                                                   384                                            904 GGGUUCC CUGAUGAGGCCGAAAGGCCGAA ACCCUAA                                                                   385                                            917 AAGUUCU CUGAUGAGGCCGAAAGGCCGAA AGCUUGG                                                                   386                                            918 AAAGUUC CUGAUGAGGCCGAAAGGCCGAA AAGCUUG                                                                   387                                            924 UUGCUUA CUGAUGAGGCCGAAAGGCCGAA AGUUCUA                                                                   388                                            925 GUUGCUU CUGAUGAGGCCGAAAGGCCGAA AAGUUCU                                                                   389                                            926 UGUUGCU CUGAUGAGGCCGAAAGGCCGAA AAAGUUC                                                                   390                                            945 GGUUUCG CUGAUGAGGCCGAAAGGCCGAA AGUGGUG                                                                   391                                            946 AGGUUUC CUGAUGAGGCCGAAAGGCCGAA AAGUGGU                                                                   392                                            959 AUUCCUG CUGAUGAGGCCGAAAGGCCGAA AUCCCAG                                                                   393                                            960 CAUUCCU CUGAUGAGGCCGAAAGGCCGAA AAUCCCA                                                                   394                                           1001 GAAUUCU CUGAUGAGGCCGAAAGGCCGAA AGUGGUU                                                                   395                                           1007 CAGUUUG CUGAUGAGGCCGAAAGGCCGAA AUUCUUA                                                                   396                                           1008 CCAGUUU CUGAUGAGGCCGAAAGGCCGAA AAUUCUU                                                                   397                                           1021 AGUUCUG CUGAUGAGGCCGAAAGGCCGAA AGGCCCC                                                                   398                                           1029 CCCCAGU CUGAUGAGGCCGAAAGGCCGAA AGUUCUG                                                                   399                                           1040 AAAGCUG CUGAUGAGGCCGAAAGGCCGAA AGGCCCC                                                                   400                                           1046 GGGAUCA CUGAUGAGGCCGAAAGGCCGAA AGCUGUA                                                                   401                                           1047 AGGGAUC CUGAUGAGGCCGAAAGGCCGAA AAGCUGU                                                                   402                                           1051 UGUCAGG CUGAUGAGGCCGAAAGGCCGAA AUCAAAG                                                                   403                                           1060 GAUUCCA CUGAUGAGGCCGAAAGGCCGAA AUGUCAG                                                                   404                                           1067 GUCUCCA CUGAUGAGGCCGAAAGGCCGAA AUUCCAG                                                                   405                                           1085 AGAACCA CUGAUGAGGCCGAAAGGCCGAA AGGCUCC                                                                   406                                           1086 CAGAACC CUGAUGAGGCCGAAAGGCCGAA AAGGCUC                                                                   407                                           1090 UGGCCAG CUGAUGAGGCCGAAAGGCCGAA ACCAAAG                                                                   408                                           1091 CUGGCCA CUGAUGAGGCCGAAAGGCCGAA AACCAAA                                                                   409                                           1113 UCUUCUC CUGAUGAGGCCGAAAGGCCGAA AGUCCUG                                                                   410                                           1124 UCUAGGU CUGAUGAGGCCGAAAGGCCGAA AGGUCUU                                                                   411                                           1129 CAAUUUC CUGAUGAGGCCGAAAGGCCGAA AGGUGAG                                                                   412                                           1135 UUGUGUC CUGAUGAGGCCGAAAGGCCGAA AUUUCUA                                                                   413                                           1151 AAGGCCU CUGAUGAGGCCGAAAGGCCGAA AGGUCCA                                                                   414                                           1152 GAAGGCC CUGAUGAGGCCGAAAGGCCGAA AAGGUCC                                                                   415                                           1158 AGAGAGG CUGAUGAGGCCGAAAGGCCGAA AGGCCUA                                                                   416                                           1159 GAGAGAG CUGAUGAGGCCGAAAGGCCGAA AAGGCCU                                                                   417                                           1162 CUGGAGA CUGAUGAGGCCGAAAGGCCGAA AGGAAGG                                                                   418                                           1164 AUCUGGA CUGAUGAGGCCGAAAGGCCGAA AGAGGAA                                                                   419                                           1166 ACAUCUG CUGAUGAGGCCGAAAGGCCGAA AGAGAGG                                                                   420                                           1174 GUCUGGA CUGAUGAGGCCGAAAGGCCGAA ACAUCUG                                                                   421                                           1175 AGUCUGG CUGAUGAGGCCGAAAGGCCGAA AACAUCU                                                                   422                                           1176 AAGUCUG CUGAUGAGGCCGAAAGGCCGAA AAACAUC                                                                   423                                           1183 CUCAAGG CUGAUGAGGCCGAAAGGCCGAA AGUCUGG                                                                   424                                           1184 UCUCAAG CUGAUGAGGCCGAAAGGCCGAA AAGUCUG                                                                   425                                           1187 GUGUCUC CUGAUGAGGCCGAAAGGCCGAA AGGAAGU                                                                   426                                           1208 CCAUGGG CUGAUGAGGCCGAAAGGCCGAA AGGGCUG                                                                   427                                           1224 AUAGAGG CUGAUGAGGCCGAAAGGCCGAA AGCUGGC                                                                   428                                           1228 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGAGC                                                                   429                                           1230 ACAUAAA CUGAUGAGGCCGAAAGGCCGAA AGAGGGA                                                                   430                                           1232 AAACAUA CUGAUGAGGCCGAAAGGCCGAA AUAGAGG                                                                   431                                           1233 CAAACAU CUGAUGAGGCCGAAAGGCCGAA AAUAGAG                                                                   432                                           1234 GCAAACA CUGAUGAGGCCGAAAGGCCGAA AAAUAGA                                                                   433                                           1238 AAGUGCA CUGAUGAGGCCGAAAGGCCGAA ACAUAAA                                                                   434                                           1239 CAAGUGC CUGAUGAGGCCGAAAGGCCGAA AACAUAA                                                                   435                                           1245 UAAUCAC CUGAUGAGGCCGAAAGGCCGAA AGUGCAA                                                                   436                                           1251 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUCACAA                                                                   437                                           1252 UAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUCACA                                                                   438                                           1254 AAUAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUCA                                                                   439                                           1255 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUC                                                                   440                                           1256 UAAAUAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                   441                                           1258 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   442                                           1259 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   443                                           1261 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                   444                                           1262 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                   445                                           1263 UAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                   446                                           1265 AAUAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   447                                           1266 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   448                                           1267 UAAAUAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAA                                                                   449                                           1269 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   450                                           1270 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   451                                           1272 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                   452                                           1273 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                   453                                           1274 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                   454                                           1276 GUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   455                                           1277 UGUAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   456                                           1278 CUGUAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAA                                                                   457                                           1280 AUCUGUA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   458                                           1281 CAUCUGU CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   459                                           1282 UCAUCUG CUGAUGAGGCCGAAAGGCCGAA AAAUAAA                                                                   460                                           1294 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA ACAUUCA                                                                   461                                           1296 CCAAAUA CUGAUGAGGCCGAAAGGCCGAA AUACAUU                                                                   462                                           1297 CCCAAAU CUGAUGAGGCCGAAAGGCCGAA AAUACAU                                                                   463                                           1298 UCCCAAA CUGAUGAGGCCGAAAGGCCGAA AAAUACA                                                                   464                                           1300 UCUCCCA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                   465                                           1301 GUCUCCC CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                   466                                           1315 CCCAGGA CUGAUGAGGCCGAAAGGCCGAA ACCCCGG                                                                   467                                           1317 CCCCCAG CUGAUGAGGCCGAAAGGCCGAA AUACCCC                                                                   468                                           1334 CAGCUCC CUGAUGAGGCCGAAAGGCCGAA ACAUUGG                                                                   469                                           1345 CUGAGCC CUGAUGAGGCCGAAAGGCCGAA AGGCAGC                                                                   470                                           1350 CAUGUCU CUGAUGAGGCCGAAAGGCCGAA AGCCAAG                                                                   471                                           1359 CACGGAA CUGAUGAGGCCGAAAGGCCGAA ACAUGUC                                                                   472                                           1360 UCACGGA CUGAUGAGGCCGAAAGGCCGAA AACAUGU                                                                   473                                           1361 UUCACGG CUGAUGAGGCCGAAAGGCCGAA AAACAUG                                                                   474                                           1362 UUUCACG CUGAUGAGGCCGAAAGGCCGAA AAAACAU                                                                   475                                           1386 AACAGCC CUGAUGAGGCCGAAAGGCCGAA AUUGUUC                                                                   476                                           1393 ACAUGGG CUGAUGAGGCCGAAAGGCCGAA ACAGCCU                                                                   477                                           1394 UACAUGG CUGAUGAGGCCGAAAGGCCGAA AACAGCC                                                                   478                                           1401 AGGGGGC CUGAUGAGGCCGAAAGGCCGAA ACAUGGG                                                                   479                                           1414 AGGCACA CUGAUGAGGCCGAAAGGCCGAA AGGCCAG                                                                   480                                           1422 UCAAAAG CUGAUGAGGCCGAAAGGCCGAA AGGCACA                                                                   481                                           1423 AUCAAAA CUGAUGAGGCCGAAAGGCCGAA AAGGCAC                                                                   482                                           1425 UAAUCAA CUGAUGAGGCCGAAAGGCCGAA AGAAGGC                                                                   483                                           1426 AUAAUCA CUGAUGAGGCCGAAAGGCCGAA AAGAAGG                                                                   484                                           1427 CAUAAUC CUGAUGAGGCCGAAAGGCCGAA AAAGAAG                                                                   485                                           1431 AAAACAU CUGAUGAGGCCGAAAGGCCGAA AUCAAAA                                                                   486                                           1432 AAAAACA CUGAUGAGGCCGAAAGGCCGAA AAUCAAA                                                                   487                                           1436 UUUAAAA CUGAUGAGGCCGAAAGGCCGAA ACAUAAU                                                                   488                                           1437 UUUUAAA CUGAUGAGGCCGAAAGGCCGAA AACAUAA                                                                   489                                           1438 AUUUUAA CUGAUGAGGCCGAAAGGCCGAA AAACAUA                                                                   490                                           1439 UAUUUUA CUGAUGAGGCCGAAAGGCCGAA AAAACAU                                                                   491                                           1440 AUAUUUU CUGAUGAGGCCGAAAGGCCGAA AAAAACA                                                                   492                                           1441 AAUAUUU CUGAUGAGGCCGAAAGGCCGAA AAAAAAC                                                                   493                                           1446 CAGAUAA CUGAUGAGGCCGAAAGGCCGAA AUUUUAA                                                                   494                                           1448 AUCAGAU CUGAUGAGGCCGAAAGGCCGAA AUAUUUU                                                                   495                                           1449 AAUCAGA CUGAUGAGGCCGAAAGGCCGAA AAUAUUU                                                                   496                                           1451 UUAAUCA CUGAUGAGGCCGAAAGGCCGAA AUAAUAU                                                                   497                                           1456 ACAACUU CUGAUGAGGCCGAAAGGCCGAA AUCAGAU                                                                   498                                           1457 GACAACU CUGAUGAGGCCGAAAGGCCGAA AAUCAGA                                                                   499                                           1461 UUUAGAC CUGAUGAGGCCGAAAGGCCGAA ACUUAAU                                                                   500                                           1464 UUGUUUA CUGAUGAGGCCGAAAGGCCGAA ACAACUU                                                                   501                                           1466 CAUUGUU CUGAUGAGGCCGAAAGGCCGAA AGACAAC                                                                   502                                           1479 GUCACCA CUGAUGAGGCCGAAAGGCCGAA AUCAGCA                                                                   503                                           1480 GGUCACC CUGAUGAGGCCGAAAGGCCGAA AAUCAGC                                                                   504                                           1494 AAUGAGU CUGAUGAGGCCGAAAGGCCGAA ACAGUUG                                                                   505                                           1498 CAGCAAU CUGAUGAGGCCGAAAGGCCGAA AGUGACA                                                                   506                                           1501 CCUCAGC CUGAUGAGGCCGAAAGGCCGAA AUGAGUG                                                                   507                                           1512 GGGAGCA CUGAUGAGGCCGAAAGGCCGAA AGGCCUC                                                                   508                                           1517 CCCUGGG CUGAUGAGGCCGAAAGGCCGAA AGCAGAG                                                                   509                                           1528 CAGACAC CUGAUGAGGCCGAAAGGCCGAA ACUCCCU                                                                   510                                           1533 GAUUACA CUGAUGAGGCCGAAAGGCCGAA ACACAAC                                                                   511                                           1537 GGCCGAU CUGAUGAGGCCGAAAGGCCGAA ACAGACA                                                                   512                                           1540 GUAGGCC CUGAUGAGGCCGAAAGGCCGAA AUUACAG                                                                   513                                           1546 UGAAUAG CUGAUGAGGCCGAAAGGCCGAA AGGCCGA                                                                   514                                           1549 CACUGAA CUGAUGAGGCCGAAAGGCCGAA AGUAGGC                                                                   515                                           1551 GCCACUG CUGAUGAGGCCGAAAGGCCGAA AUAGUAG                                                                   516                                           1552 CGCCACU CUGAUGAGGCCGAAAGGCCGAA AAUAGUA                                                                   517                                           1566 CAACCUU CUGAUGAGGCCGAAAGGCCGAA AUUUCUC                                                                   518                                           1572 CCUAAGC CUGAUGAGGCCGAAAGGCCGAA ACCUUUA                                                                   519                                           1576 CUUUCCU CUGAUGAGGCCGAAAGGCCGAA AGCAACC                                                                   520                                           1577 UCUUUCC CUGAUGAGGCCGAAAGGCCGAA AAGCAAC                                                                   521                                           __________________________________________________________________________

                                      TABLE IV                                    __________________________________________________________________________    Mouse TNF-a HH Target Sequences                                               nt.             Sequence                                                                           nt.             Sequence                                 Position                                                                          HH Target Sequence                                                                        ID No.                                                                             Position                                                                          HH Target Sequence                                                                        ID No.                                   __________________________________________________________________________     66 UgGAAAU a GcucCcA                                                                         522   324                                                                              GgGUGAU C GGuCCCC                                                                         562                                       101                                                                              GGCAGGU U CUgUcCC                                                                         523   347                                                                              GAGAagU u cCCAaaU                                                                         563                                       101                                                                              GGCAGgU u CUGUccC                                                                         524   364                                                                              CCUCcCU C UcAUCAG                                                                         564                                       102                                                                              GCAGGUU C UgUcCCU                                                                         525   366                                                                              UCcCUCU c AUCAGuu                                                                         565                                       102                                                                              gCAGgUU c ugUCCCU                                                                         526   366                                                                              UcCCUCU C auCAGuU                                                                         566                                       106                                                                              GUUCUgU c CCUuUCA                                                                         527   369                                                                              CUCUcAU C AGuuCUa                                                                         567                                       110                                                                              UgUcCCU u UCACucA                                                                         528   376                                                                              CAGuuCU a UGGCCCA                                                                         568                                       111                                                                              gUCcCUU u CaCUCAC                                                                         529   390                                                                              AgACCCU C AcaCUcA                                                                         569                                       111                                                                              guCCCuU u CACuCAc                                                                         530   396                                                                              ucaCAcU C AGAUCAU                                                                         570                                       112                                                                              UcCCUuU C ACucACU                                                                         531   401                                                                              cUCAGAU C AUCUUCU                                                                         571                                       116                                                                              UuUCACU C AcUGgcc                                                                         532   404                                                                              AGAUCAU C UUCUCaA                                                                         572                                       137                                                                              GCCaCAU C uCCcUCc                                                                         533   406                                                                              AUCAUCU U CUCaAAa                                                                         573                                       139                                                                              caCAuCU C CCUCcAg                                                                         534   406                                                                              AUcAUcU U cUcaAAA                                                                         574                                       177                                                                              GCAUGAU C CGcGACG                                                                         535   407                                                                              UCAUCUU C UCaAAau                                                                         575                                       207                                                                              AGGCaCU C CCCcAaA                                                                         536   409                                                                              AUCUUCU C aAAauuC                                                                         576                                       228                                                                              GGGGCuU C CAGAACU                                                                         537   409                                                                              AuCuuCU c AaAAUUC                                                                         577                                       228                                                                              GGGGCuU c CAGaacU                                                                         538   409                                                                              aUcUUcU c AAAauUc                                                                         578                                       236                                                                              CAGaaCU C CAGGCGG                                                                         539   432                                                                              ACCCUGU A GCCCAcG                                                                         579                                       236                                                                              CAGaACU c cAGgcGg                                                                         540                                                            249                                                                              GGugCCU a UgUCUcA                                                                         541                                                            249                                                                              GGuGCCU a UGucUCa                                                                         542   444                                                                              AcGUcGU A GCAAACC                                                                         580                                                            501                                                                              AcGCCCU C CUGGCCA                                                                         581                                       261                                                                              UCAGCCU C UUCUCaU                                                                         543   560                                                                              gGgUUGU a CCUuguC                                                                         582                                       261                                                                              UCAgCCU C UUCUcau                                                                         544   560                                                                              GGguUGU A CCUugUC                                                                         583                                       263                                                                              AGCCUCU U CUCaUUC                                                                         545   564                                                                              UGUACCU u gUCUACU                                                                         584                                       263                                                                              AgCCUCU U CUcauUC                                                                         546   567                                                                              ACCUugU C UACUCCC                                                                         585                                       264                                                                              GCCUCUU C UCaUUCC                                                                         547   569                                                                              CUugUCU A CUCCCAG                                                                         586                                       264                                                                              gCCUCUU C UcauUCc                                                                         548   572                                                                              gUCUACU C CCAGGUu                                                                         587                                       266                                                                              CUCUUCU C aUUCCUG                                                                         549   572                                                                              GUCUaCU c CCAGguu                                                                         588                                       269                                                                              UUCUCaU U CCUGcUu                                                                         550   572                                                                              GuCUacU C CCAgGUu                                                                         589                                       270                                                                              UCUCaUU C CUGcUuG                                                                         551   579                                                                              CCCAGGU u CUCUUCA                                                                         590                                       276                                                                              UCCUGcU u GUGGCAG                                                                         552   580                                                                              CCAGguU c uCUUcAa                                                                         591                                       297                                                                              CCACGCU C UUCUGuC                                                                         553   580                                                                              CCaGGuU c UCuUcaa                                                                         592                                       299                                                                              ACGCUCU U CUGuCUa                                                                         554   582                                                                              AGGUUCU C UUCaagg                                                                         593                                       300                                                                              CGCUCUU C UGuCUaC                                                                         555   582                                                                              AGGUuCU C UUCAAGG                                                                         594                                       304                                                                              CUuCUgU c uAcUGaa                                                                         556   584                                                                              GUuCUCU U CAAGGGa                                                                         595                                       306                                                                              UcUGUcU a cUgAAcU                                                                         557   585                                                                              UuCUCUU C AAGGGaC                                                                         596                                       314                                                                              CUGaACU U cGGgGUG                                                                         558   608                                                                              CcCGaCU a CgugCUC                                                                         597                                       315                                                                              UGaACUU c GGgGUGA                                                                         559   615                                                                              aCgUGcU C CUCAcCC                                                                         598                                       315                                                                              uGaaCUU c GGGguGa                                                                         560   615                                                                              AcGUGCU C CUCACCC                                                                         599                                       324                                                                              gGGUGaU c GgUCCcC                                                                         561   618                                                                              UGCUCCU C ACCCACA                                                                         600                                       630                                                                              ACACCgU C AGCCGau                                                                         601   940                                                                              GuCUACU c cUCAGaG                                                                         650                                       630                                                                              ACACCgU C AgCCgaU                                                                         602   943                                                                              UACUccU C AGaGcCc                                                                         651                                       638                                                                              agcCgAU u uGCUaUc                                                                         603   972                                                                              UCUaaCU u AgAAAGg                                                                         652                                       643                                                                              aUUUGcU a uCUcAuA                                                                         604   972                                                                              ucUaaCU u AGAaAgG                                                                         653                                       645                                                                              UuGCuaU C UCaUACC                                                                         605   973                                                                              CUaACuU A GAAAggG                                                                         654                                       647                                                                              GCuaUCU C aUACCAG                                                                         606   984                                                                              AGgGgAU U auGGcuc                                                                         655                                       663                                                                              agAAaGU C AACCUCC                                                                         607   984                                                                              AGGGgaU U aUGgCUc                                                                         656                                       669                                                                              UCAACCU C CUCUCUG                                                                         608   985                                                                              GGGGauU a uGGcUCa                                                                         657                                       669                                                                              UcAAccU c cUcUCUG                                                                         609   997                                                                              UcAGAgU c CAAcucu                                                                         658                                       672                                                                              ACCUCCU C UCUGCCg                                                                         610  1010                                                                              CuguGCU c AGAgCUU                                                                         659                                       674                                                                              CUCCUCU C UGCCgUC                                                                         611  1017                                                                              cAGAgCU U UcAaCAA                                                                         660                                       681                                                                              cUGCCgU C AagaGcC                                                                         612  1018                                                                              AGAgCUU U cAaCAAC                                                                         661                                       681                                                                              CUGCCgU C AAGAGCC                                                                         613  1019                                                                              GAgCUUU c AaCAACu                                                                         662                                       681                                                                              CUGcCgU C aaGAgcC                                                                         614  1073                                                                              UgGGCCU c ucAUgCA                                                                         663                                       734                                                                              CCCUGGU A UGAGCCC                                                                         615  1096                                                                              AAGgAcU C AAAugGG                                                                         664                                       734                                                                              CccUGGU a ugaGCCc                                                                         616  1106                                                                              aUGGGcU U uccGAAU                                                                         665                                       744                                                                              AGCCCAU a UAcCUGG                                                                         617  1107                                                                              UGGGcUU u ccGAAUu                                                                         666                                       746                                                                              CCCAUaU A cCUGGGA                                                                         618  1108                                                                              GGgCuUU c cGaaUUC                                                                         667                                       759                                                                              GAgGAGU C uuCCAGc                                                                         619  1115                                                                              CcGAAuU C ACUGGaG                                                                         668                                       759                                                                              GAGGaGU C UUCCAGC                                                                         620  1133                                                                              CGAAugU C CAuuCcU                                                                         669                                       761                                                                              GGaGUCU U CCAGCUG                                                                         621  1164                                                                              gagUGgU c AgGUUGc                                                                         670                                       762                                                                              GaGUCUU C CAGCUGG                                                                         622  1180                                                                              UcUgUcU c agaAUGA                                                                         671                                       786                                                                              ACCaACU C AGCGCUG                                                                         623  1203                                                                              aaGAuCU c AGGCCUU                                                                         672                                       798                                                                              CUGAGgU C AAUCuGC                                                                         624  1210                                                                              cAGGCCU U CCUacCU                                                                         673                                       802                                                                              GgUCAAU C uGCCCaA                                                                         625  1211                                                                              AGGCCUU C CUacCUu                                                                         674                                       812                                                                              CCCaAgU A cuUaGAC                                                                         626  1214                                                                              CCUUCCU a cCUuCAG                                                                         675                                       816                                                                              AgUAcuU a GACUUUG                                                                         627  1218                                                                              CcuACcU u CaGACCu                                                                         676                                       821                                                                              uUaGACU U UGCgGAG                                                                         628  1218                                                                              CCuaCCU U CAGACcu                                                                         677                                       822                                                                              UaGACUU U GCgGAGU                                                                         629  1218                                                                              cCuACcU u cAgACCU                                                                         678                                       830                                                                              GCgGAGU C cGGGCAG                                                                         630  1218                                                                              CCUacCU u CAGAccU                                                                         679                                       840                                                                              GGCAGGU C UACUUUG                                                                         631  1219                                                                              CuaCCUU C AGACcuu                                                                         680                                       842                                                                              CAGGUCU A CUUUGGa                                                                         632  1219                                                                              CuAcCUU c agACcUU                                                                         681                                       842                                                                              CAGgucU a CUUugGA                                                                         633  1226                                                                              CagACCU U uCCAgAC                                                                         682                                       842                                                                              cagGuCU a CUUUgGA                                                                         634  1226                                                                              CAGAccU U UCCAGAC                                                                         683                                       845                                                                              GUCUACU U UGGagUC                                                                         635  1227                                                                              agACCUU u CCAgACu                                                                         684                                       846                                                                              UCUACUU U GGagUCA                                                                         636  1227                                                                              GAccUUU C CCAGACU                                                                         685                                       852                                                                              UUGGagU C AUUGCuC                                                                         637  1228                                                                              GAccUUU C CAGACUc                                                                         686                                       855                                                                              GagUCAU U GCuCUGU                                                                         638  1238                                                                              gACUCuU c cCUGAGG                                                                         687                                       887                                                                              AUCCaUU c ucUACCC                                                                         639  1262                                                                              CAGCCuU C CuCAcaG                                                                         688                                       891                                                                              AuucuCU a CCCaGCC                                                                         640  1283                                                                              CCCCccU C uaUUUAU                                                                         689                                       905                                                                              CCcCaCU C UgaCCCC                                                                         641  1283                                                                              cCcCCCU C UAUUUAU                                                                         690                                       905                                                                              cCCCacU c UgACCCC                                                                         642  1285                                                                              cCCCUCU A UUUAUaU                                                                         691                                       905                                                                              CcCCACU c uGAccCC                                                                         643  1287                                                                              CcuCUAU u UauAuUU                                                                         692                                       914                                                                              GAcCCcU U uacUCUG                                                                         644  1287                                                                              CCUCUAU U UAUaUUU                                                                         693                                       915                                                                              ACCCCuU u acUCuGA                                                                         645  1288                                                                              CUCUAUU U AUaUUUG                                                                         694                                       919                                                                              CUUUAcU c ugaCCcC                                                                         646  1289                                                                              UCUAUUU A UaUUUGC                                                                         695                                       928                                                                              GACCcCU u UaUugUC                                                                         647  1293                                                                              UUUAUaU U UGCACUU                                                                         696                                       928                                                                              gAcCCCU U UAUUguC                                                                         648  1293                                                                              uUUaUaU u UGcAcUu                                                                         697                                       932                                                                              CCUUUAU U guCuaCU                                                                         649  1294                                                                              UUAUaUU U GCACUUa                                                                         698                                      1300                                                                              UUGCACU U aUuAUUu                                                                         699  1462                                                                              aCCuUGU u GCCuCCU                                                                         747                                      1303                                                                              CAcuUaU u AuUuAUU                                                                         700  1470                                                                              GccuCcU C UUUUGcU                                                                         748                                      1304                                                                              acUuAUU A UUUAUUA                                                                         701  1472                                                                              cuCcUCU U UUGcUUA                                                                         749                                      1306                                                                              UuAUUAU U UAUUAUU                                                                         702  1473                                                                              uCcUCUU U UGcUUAU                                                                         750                                      1307                                                                              uAUUAUU U AUUAUUU                                                                         703  1474                                                                              CcUCUUU U GcUUAUG                                                                         751                                      1307                                                                              UaUUaUU U AuuAUuU                                                                         704  1478                                                                              UUUUGcU U AUGUUUa                                                                         752                                      1308                                                                              UUAUUU A UUAUUUA                                                                          705  1479                                                                              UUUGcUU a UGuuuAa                                                                         753                                      1310                                                                              UauUuAU U AUUUAUU                                                                         706  1479                                                                              UUUGcUU A UGUUUaa                                                                         754                                      1310                                                                              UAUUUAU U AUUUAUU                                                                         707  1484                                                                              UUAUGUU U aaaAcAA                                                                         755                                      1310                                                                              UAUUUAU U AUUUAUU                                                                         708  1498                                                                              AAAuauU U AUCUaAc                                                                         756                                      1311                                                                              AUUUAUU A UUUAUUU                                                                         709  1511                                                                              AcccAaU U GUCUuAA                                                                         757                                      1311                                                                              AUUUAUU A UUUAUUU                                                                         710  1514                                                                              cAaUUGU C UuAAuAA                                                                         758                                      1311                                                                              AuuUAUU A UuUauUU                                                                         711  1516                                                                              aUUGUCU u AAuAAcG                                                                         759                                      1313                                                                              UUAUUAU U UAUUUAU                                                                         712  1529                                                                              CgcugAU u UGGuGAC                                                                         760                                      1313                                                                              UUAUUAU U UAUUUAU                                                                         713  1529                                                                              cGCUGAU U UGGUGAC                                                                         761                                      1313                                                                              uUAUUAU u UauUUAu                                                                         714  1530                                                                              gCUGAUU u gGUgacC                                                                         762                                      1314                                                                              UAUUAUU U AUUUAUU                                                                         715  1530                                                                              GCUGAUU U GGUGACC                                                                         763                                      1314                                                                              UAUUAUU U AUUUAUU                                                                         716  1563                                                                              UgaAcCU c UGcUCCC                                                                         764                                      1315                                                                              AUUAUUU A UUUAUUA                                                                         717  1563                                                                              ugaaCCU C UGCUCCC                                                                         765                                      1317                                                                              UAUUUAU U UAUUAUU                                                                         718  1568                                                                              CUCUGCU C CCCAcGG                                                                         766                                      1318                                                                              AUUUAUU U AUUAUUU                                                                         719  1589                                                                              UGaCUGU A AUuGcCC                                                                         767                                      1319                                                                              UUUAUUU A UUAUUUA                                                                         720  1592                                                                              CUGUAAU u GcCCUAC                                                                         768                                      1326                                                                              AUUAUUU A UUUAUUU                                                                         721  1617                                                                              GAGAAAU A AAGaUcG                                                                         769                                      1328                                                                              UAUUUAU U UAUUUgC                                                                         722  1623                                                                              UAAAGaU c GCUUAaa                                                                         770                                      1329                                                                              AUUUAUU U AUUUgCu                                                                         723  1633                                                                              UUAaaaU a aaAAaCC                                                                         771                                      1330                                                                              UUUAUUU A UUUgCuu                                                                         724  25  AgGgaCU a gCCagGA                                                                         772                                      1332                                                                              UAUUUAU U UgCuuAU                                                                         725                                                           1333                                                                              AUUUAUU U gCuuAUG                                                                         726                                                           1337                                                                              auUUGCU U AuGAAuG                                                                         727                                                           1338                                                                              uUUGCUU A uGAAuGu                                                                         728                                                           1346                                                                              UGAAUGU A UUUAUUU                                                                         729                                                           1348                                                                              AAUGUAU U UAUUUGG                                                                         730                                                           1349                                                                              AUGUAUU U AUUUGGa                                                                         731                                                           1350                                                                              UGUAUUU A UUUGGaA                                                                         732                                                           1352                                                                              uAUuUAU u UGGaAGG                                                                         733                                                           1352                                                                              UAUUUAU U UGGaAGg                                                                         734                                                           1353                                                                              AUUUAUU U GGaAGgC                                                                         735                                                           1369                                                                              GGGGUgU C CUGGaGG                                                                         736                                                           1398                                                                              gCUguCU U cAGACAg                                                                         737                                                           1398                                                                              GCUGuCU U cagaCAG                                                                         738                                                           1412                                                                              GACAUGU U UUCuGUG                                                                         739                                                           1413                                                                              ACAUGUU U UCuGUGA                                                                         740                                                           1414                                                                              CAUGUUU U CuGUGAA                                                                         741                                                           1415                                                                              AUGUUUU C uGUGAAA                                                                         742                                                           1415                                                                              AUGUUUU c UgugAaA                                                                         743                                                           1438                                                                              gaGCUGU c CCCAccU                                                                         744                                                           1451                                                                              CUGGCCU C UcUaCCU                                                                         745                                                           1453                                                                              ggCCUCU C UaCCuUG                                                                         746                                                           __________________________________________________________________________

                                      TABLE V                                     __________________________________________________________________________    Mouse TNF-a Hammerhead Ribozyme Sequences                                     nt.                             Sequence                                      Position                                                                           Mouse HH Ribozyme Sequence ID No.                                        __________________________________________________________________________     25  UCCUGGC CUGAUGAGGCCGAAAGGCCGAA AGUCCCU                                                                    773                                           66  UGGGAGC CUGAUGAGGCCGAAAGGCCGAA AUUUCCA                                                                    774                                           101 GGGACAG CUGAUGAGGCCGAAAGGCCGAA ACCUGCC                                                                    775                                           101 GGGACAG CUGAUGAGGCCGAAAGGCCGAA ACCUGCC                                                                    776                                           102 AGGGACA CUGAUGAGGCCGAAAGGCCGAA AACCUGC                                                                    777                                           102 AGGGACA CUGAUGAGGCCGAAAGGCCGAA AACCUGC                                                                    778                                           106 UGAAAGG CUGAUGAGGCCGAAAGGCCGAA ACAGAAC                                                                    779                                           110 UGAGUGA CUGAUGAGGCCGAAAGGCCGAA AGGGACA                                                                    780                                           111 GUGAGUG CUGAUGAGGCCGAAAGGCCGAA AAGGGAC                                                                    781                                           111 GUGAGUG CUGAUGAGGCCGAAAGGCCGAA AAGGGAC                                                                    782                                           112 AGUGAGU CUGAUGAGGCCGAAAGGCCGAA AAAGGGA                                                                    783                                           116 GGCCAGU CUGAUGAGGCCGAAAGGCCGAA AGUGAAA                                                                    784                                           137 GGAGGGA CUGAUGAGGCCGAAAGGCCGAA AUGUGGC                                                                    785                                           139 CUGGAGG CUGAUGAGGCCGAAAGGCCGAA AGAUGUG                                                                    786                                           177 CGUCGCG CUGAUGAGGCCGAAAGGCCGAA AUCAUGC                                                                    787                                           207 UUUGGGG CUGAUGAGGCCGAAAGGCCGAA AGUGCCU                                                                    788                                           228 AGUUCUG CUGAUGAGGCCGAAAGGCCGAA AAGCCCC                                                                    789                                           228 AGUUCUG CUGAUGAGGCCGAAAGGCCGAA AAGCCCC                                                                    790                                           236 CCGCCUG CUGAUGAGGCCGAAAGGCCGAA AGUUCUG                                                                    791                                           236 CCGCCUG CUGAUGAGGCCGAAAGGCCGAA AGUUCUG                                                                    792                                           249 UGAGACA CUGAUGAGGCCGAAAGGCCGAA AGGCACC                                                                    793                                           249 UGAGACA CUGAUGAGGCCGAAAGGCCGAA AGGCACC                                                                    794                                           261 AUGAGAA CUGAUGAGGCCGAAAGGCCGAA AGGCUGA                                                                    795                                           261 AUGAGAA CUGAUGAGGCCGAAAGGCCGAA AGGCUGA                                                                    796                                           263 GAAUGAG CUGAUGAGGCCGAAAGGCCGAA AGAGGCU                                                                    797                                           263 GAAUGAG CUGAUGAGGCCGAAAGGCCGAA AGAGGCU                                                                    798                                           264 GGAAUGA CUGAUGAGGCCGAAAGGCCGAA AAGAGGC                                                                    799                                           264 GGAAUGA CUGAUGAGGCCGAAAGGCCGAA AAGAGGC                                                                    800                                           266 CAGGAAU CUGAUGAGGCCGAAAGGCCGAA AGAAGAG                                                                    801                                           269 AAGCAGG CUGAUGAGGCCGAAAGGCCGAA AUGAGAA                                                                    802                                           270 CAAGCAG CUGAUGAGGCCGAAAGGCCGAA AAUGAGA                                                                    803                                           276 CUGCCAC CUGAUGAGGCCGAAAGGCCGAA AGCAGGA                                                                    804                                           297 GACAGAA CUGAUGAGGCCGAAAGGCCGAA AGCGUGG                                                                    805                                           299 UAGACAG CUGAUGAGGCCGAAAGGCCGAA AGAGCGU                                                                    806                                           300 GUAGACA CUGAUGAGGCCGAAAGGCCGAA AAGAGCG                                                                    807                                           304 UUCAGUA CUGAUGAGGCCGAAAGGCCGAA ACAGAAG                                                                    808                                           306 AGUUCAG CUGAUGAGGCCGAAAGGCCGAA AGACAGA                                                                    809                                           314 CACCCCG CUGAUGAGGCCGAAAGGCCGAA AGUUCAG                                                                    810                                           315 UCACCCC CUGAUGAGGCCGAAAGGCCGAA AAGUUCA                                                                    811                                           315 UCACCCC CUGAUGAGGCCGAAAGGCCGAA AAGUUCA                                                                    812                                           324 GGGGACC CUGAUGAGGCCGAAAGGCCGAA AUCACCC                                                                    813                                           324 GGGGACC CUGAUGAGGCCGAAAGGCCGAA AUCACCC                                                                    814                                           347 AUUUGGG CUGAUGAGGCCGAAAGGCCGAA ACUUCUC                                                                    815                                           364 CUGAUGA CUGAUGAGGCCGAAAGGCCGAA AGGGAGG                                                                    816                                           366 AACUGAU CUGAUGAGGCCGAAAGGCCGAA AGAGGGA                                                                    817                                           366 AACUGAU CUGAUGAGGCCGAAAGGCCGAA AGAGGGA                                                                    818                                           369 UAGAACU CUGAUGAGGCCGAAAGGCCGAA AUGAGAG                                                                    819                                           376 UGGGCCA CUGAUGAGGCCGAAAGGCCGAA AGAACUG                                                                    820                                           390 UGAGUGU CUGAUGAGGCCGAAAGGCCGAA AGGGUCU                                                                    821                                           396 AUGAUCU CUGAUGAGGCCGAAAGGCCGAA AGUGUGA                                                                    822                                           401 AGAAGAU CUGAUGAGGCCGAAAGGCCGAA AUCUGAG                                                                    823                                           404 UUGAGAA CUGAUGAGGCCGAAAGGCCGAA AUGAUCU                                                                    824                                           406 UUUUGAG CUGAUGAGGCCGAAAGGCCGAA AGAUGAU                                                                    825                                           406 UUUUGAG CUGAUGAGGCCGAAAGGCCGAA AGAUGAU                                                                    826                                           407 AUUUUGA CUGAUGAGGCCGAAAGGCCGAA AAGAUGA                                                                    827                                           409 GAAUUUU CUGAUGAGGCCGAAAGGCCGAA AGAAGAU                                                                    828                                           409 GAAUUUU CUGAUGAGGCCGAAAGGCCGAA AGAAGAU                                                                    829                                           409 GAAUUUU CUGAUGAGGCCGAAAGGCCGAA AGAAGAU                                                                    830                                           432 CGUGGGC CUGAUGAGGCCGAAAGGCCGAA ACAGGCU                                                                    831                                           444 GGUUUGC CUGAUGAGGCCGAAAGGCCGAA ACGACGU                                                                    832                                           501 UGGCCAG CUGAUGAGGCCGAAAGGCCGAA AGGGCGU                                                                    833                                           560 GACAAGG CUGAUGAGGCCGAAAGGCCGAA ACAACCC                                                                    834                                           560 GACAAGG CUGAUGAGGCCGAAAGGCCGAA ACAACCC                                                                    835                                           564 AGUAGAC CUGAUGAGGCCGAAAGGCCGAA AGGUACA                                                                    836                                           567 GGGAGUA CUGAUGAGGCCGAAAGGCCGAA ACAAGGU                                                                    837                                           569 CUGGGAG CUGAUGAGGCCGAAAGGCCGAA AGACAAG                                                                    838                                           572 AACCUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                    839                                           572 AACCUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                    840                                           572 AACCUGG CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                    841                                           579 UGAAGAG CUGAUGAGGCCGAAAGGCCGAA ACCUGGG                                                                    842                                           580 UUGAAGA CUGAUGAGGCCGAAAGGCCGAA AACCUGG                                                                    843                                           580 UUGAAGA CUGAUGAGGCCGAAAGGCCGAA AACCUGG                                                                    844                                           582 CCUUGAA CUGAUGAGGCCGAAAGGCCGAA AGAACCU                                                                    845                                           582 CCUUGAA CUGAUGAGGCCGAAAGGCCGAA AGAACCU                                                                    846                                           584 UCCCUUG CUGAUGAGGCCGAAAGGCCGAA AGAGAAC                                                                    847                                           585 GUCCCUU CUGAUGAGGCCGAAAGGCCGAA AAGAGAA                                                                    848                                           608 GAGCACG CUGAUGAGGCCGAAAGGCCGAA AGUCGGG                                                                    849                                           615 GGGUGAG CUGAUGAGGCCGAAAGGCCGAA AGCACGU                                                                    850                                           615 GGGUGAG CUGAUGAGGCCGAAAGGCCGAA AGCACGU                                                                    851                                           618 UGUGGGU CUGAUGAGGCCGAAAGGCCGAA AGGAGCA                                                                    852                                           630 AUCGGCU CUGAUGAGGCCGAAAGGCCGAA ACGGUGU                                                                    853                                           630 AUCGGCU CUGAUGAGGCCGAAAGGCCGAA ACGGUGU                                                                    854                                           638 GAUAGCA CUGAUGAGGCCGAAAGGCCGAA AUCGGCU                                                                    855                                           643 UAUGAGA CUGAUGAGGCCGAAAGGCCGAA AGCAAAU                                                                    856                                           645 GGUAUGA CUGAUGAGGCCGAAAGGCCGAA AUAGCAA                                                                    857                                           647 CUGGUAU CUGAUGAGGCCGAAAGGCCGAA AGAUAGC                                                                    858                                           663 GGAGGUU CUGAUGAGGCCGAAAGGCCGAA ACUUUCU                                                                    859                                           669 CAGAGAG CUGAUGAGGCCGAAAGGCCGAA AGGUUGA                                                                    860                                           669 CAGAGAG CUGAUGAGGCCGAAAGGCCGAA AGGUUGA                                                                    861                                           672 CGGCAGA CUGAUGAGGCCGAAAGGCCGAA AGGAGGU                                                                    862                                           674 GACGGCA CUGAUGAGGCCGAAAGGCCGAA AGAGGAG                                                                    863                                           681 GGCUCUU CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                    864                                           681 GGCUCUU CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                    865                                           681 GGCUCUU CUGAUGAGGCCGAAAGGCCGAA ACGGCAG                                                                    866                                           734 GGGCUCA CUGAUGAGGCCGAAAGGCCGAA ACCAGGG                                                                    867                                           734 GGGCUCA CUGAUGAGGCCGAAAGGCCGAA ACCAGGG                                                                    868                                           744 CCAGGUA CUGAUGAGGCCGAAAGGCCGAA AUGGGCU                                                                    869                                           746 UCCCAGG CUGAUGAGGCCGAAAGGCCGAA AUAUGGG                                                                    870                                           759 GCUGGAA CUGAUGAGGCCGAAAGGCCGAA ACUCCUC                                                                    871                                           759 GCUGGAA CUGAUGAGGCCGAAAGGCCGAA ACUCCUC                                                                    872                                           761 CAGCUGG CUGAUGAGGCCGAAAGGCCGAA AGACUCC                                                                    873                                           762 CCAGCUG CUGAUGAGGCCGAAAGGCCGAA AAGACUC                                                                    874                                           786 CAGCGCU CUGAUGAGGCCGAAAGGCCGAA AGUUGGU                                                                    875                                           798 GCAGAUU CUGAUGAGGCCGAAAGGCCGAA ACCUCAG                                                                    876                                           802 UUGGGCA CUGAUGAGGCCGAAAGGCCGAA AUUGACC                                                                    877                                           812 GUCUAAG CUGAUGAGGCCGAAAGGCCGAA ACUUGGG                                                                    878                                           816 CAAAGUC CUGAUGAGGCCGAAAGGCCGAA AAGUACU                                                                    879                                           821 CUCCGCA CUGAUGAGGCCGAAAGGCCGAA AGUCUAA                                                                    880                                           822 ACUCCGC CUGAUGAGGCCGAAAGGCCGAA AAGUCUA                                                                    881                                           830 CUGCCCG CUGAUGAGGCCGAAAGGCCGAA ACUCCGC                                                                    882                                           840 CAAAGUA CUGAUGAGGCCGAAAGGCCGAA ACCUGCC                                                                    883                                           842 UCCAAAG CUGAUGAGGCCGAAAGGCCGAA AGACCUG                                                                    884                                           842 UCCAAAG CUGAUGAGGCCGAAAGGCCGAA AGACCUG                                                                    885                                           842 UCCAAAG CUGAUGAGGCCGAAAGGCCGAA AGACCUG                                                                    886                                           845 GACUCCA CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                    887                                           846 UGACUCC CUGAUGAGGCCGAAAGGCCGAA AAGUAGA                                                                    888                                           852 GAGCAAU CUGAUGAGGCCGAAAGGCCGAA ACUCCAA                                                                    889                                           855 ACAGAGC CUGAUGAGGCCGAAAGGCCGAA AUGACUC                                                                    890                                           887 GGGUAGA CUGAUGAGGCCGAAAGGCCGAA AAUGGAU                                                                    891                                           891 GGCUGGG CUGAUGAGGCCGAAAGGCCGAA AGAGAAU                                                                    892                                           905 GGGGUCA CUGAUGAGGCCGAAAGGCCGAA AGUGGGG                                                                    893                                           905 GGGGUCA CUGAUGAGGCCGAAAGGCCGAA AGUGGGG                                                                    894                                           905 GGGGUCA CUGAUGAGGCCGAAAGGCCGAA AGUGGGG                                                                    895                                           914 CAGAGUA CUGAUGAGGCCGAAAGGCCGAA AGGGGUC                                                                    896                                           915 UCAGAGU CUGAUGAGGCCGAAAGGCCGAA AAGGGGU                                                                    897                                           919 GGGGUCA CUGAUGAGGCCGAAAGGCCGAA AGUAAAG                                                                    898                                           928 GACAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGGUC                                                                    899                                           928 GACAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGGUC                                                                    900                                           932 AGUAGAC CUGAUGAGGCCGAAAGGCCGAA AUAAAGG                                                                    901                                           940 CUCUGAG CUGAUGAGGCCGAAAGGCCGAA AGUAGAC                                                                    902                                           943 GGGCUCU CUGAUGAGGCCGAAAGGCCGAA AGGAGUA                                                                    903                                           972 CCUUUCU CUGAUGAGGCCGAAAGGCCGAA AGUUAGA                                                                    904                                           972 CCUUUCU CUGAUGAGGCCGAAAGGCCGAA AGUUAGA                                                                    905                                           973 CCCUUUC CUGAUGAGGCCGAAAGGCCGAA AAGUUAG                                                                    906                                           984 GAGCCAU CUGAUGAGGCCGAAAGGCCGAA AUCCCCU                                                                    907                                           984 GAGCCAU CUGAUGAGGCCGAAAGGCCGAA AUCCCCU                                                                    908                                           985 UGAGCCA CUGAUGAGGCCGAAAGGCCGAA AAUCCCC                                                                    909                                           997 AGAGUUG CUGAUGAGGCCGAAAGGCCGAA ACUCUGA                                                                    910                                          1010 AAGCUCU CUGAUGAGGCCGAAAGGCCGAA AGCACAG                                                                    911                                          1017 UUUUUGA CUGAUGAGGCCGAAAGGCCGAA AGCUCUG                                                                    912                                          1018 GUUGUUG CUGAUGAGGCCGAAAGGCCGAA AAGCUCU                                                                    913                                          1019 AGUUGUU CUGAUGAGGCCGAAAGGCCGAA AAAGCUC                                                                    914                                          1073 UGCAUGA CUGAUGAGGCCGAAAGGCCGAA AGGCCCA                                                                    915                                          1096 CCCAUUU CUGAUGAGGCCGAAAGGCCGAA AGUCCUU                                                                    916                                          1106 AUUCGGA CUGAUGAGGCCGAAAGGCCGAA AGCCCAU                                                                    917                                          1107 AAUUCGG CUGAUGAGGCCGAAAGGCCGAA AAGCCCA                                                                    918                                          1108 GAAUUCG CUGAUGAGGCCGAAAGGCCGAA AAAGCCC                                                                    919                                          1115 CUCCAGU CUGAUGAGGCCGAAAGGCCGAA AAUUCGG                                                                    920                                          1133 AGGAAUG CUGAUGAGGCCGAAAGGCCGAA ACAUUCG                                                                    921                                          1164 GCAACCU CUGAUGAGGCCGAAAGGCCGAA ACCACUC                                                                    922                                          1180 UCAUUCU CUGAUGAGGCCGAAAGGCCGAA AGACAGA                                                                    923                                          1203 AAGGCCU CUGAUGAGGCCGAAAGGCCGAA AGAUCUU                                                                    924                                          1210 AGGUAGG CUGAUGAGGCCGAAAGGCCGAA AGGCCUG                                                                    925                                          1211 AAGGUAG CUGAUGAGGCCGAAAGGCCGAA AAGGCCU                                                                    926                                          1214 CUGAAGG CUGAUGAGGCCGAAAGGCCGAA AGGAAGG                                                                    927                                          1218 AGGUCUG CUGAUGAGGCCGAAAGGCCGAA AGGUAGG                                                                    928                                          1218 AGGUCUG CUGAUGAGGCCGAAAGGCCGAA AGGUAGG                                                                    929                                          1218 AGGUCUG CUGAUGAGGCCGAAAGGCCGAA AGGUAGG                                                                    930                                          1218 AGGUCUG CUGAUGAGGCCGAAAGGCCGAA AGGUAGG                                                                    931                                          1219 AAGGUCU CUGAUGAGGCCGAAAGGCCGAA AAGGUAG                                                                    932                                          1219 AAGGUCU CUGAUGAGGCCGAAAGGCCGAA AAGGUAG                                                                    933                                          1226 GUCUGGA CUGAUGAGGCCGAAAGGCCGAA AGGUCUG                                                                    934                                          1226 GUCUGGA CUGAUGAGGCCGAAAGGCCGAA AGGUCUG                                                                    935                                          1227 AGUCUGG CUGAUGAGGCCGAAAGGCCGAA AAGGUCU                                                                    936                                          1227 AGUCUGG CUGAUGAGGCCGAAAGGCCGAA AAGGUCU                                                                    937                                          1228 GAGUCUG CUGAUGAGGCCGAAAGGCCGAA AAAGGUC                                                                    938                                          1238 CCUCAGG CUGAUGAGGCCGAAAGGCCGAA AAGAGUC                                                                    939                                          1262 CUGUGAG CUGAUGAGGCCGAAAGGCCGAA AAGGCUG                                                                    940                                          1283 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGGGG                                                                    941                                          1283 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AGGGGGG                                                                    942                                          1285 AUAUAAA CUGAUGAGGCCGAAAGGCCGAA AGAGGGG                                                                    943                                          1287 AAAUAUA CUGAUGAGGCCGAAAGGCCGAA AUAGAGG                                                                    944                                          1287 AAAUAUA CUGAUGAGGCCGAAAGGCCGAA AUAGAGG                                                                    945                                          1288 CAAAUAU CUGAUGAGGCCGAAAGGCCGAA AAUAGAG                                                                    946                                          1289 GCAAAUA CUGAUGAGGCCGAAAGGCCGAA AAAUAGA                                                                    947                                          1293 AAGUGCA CUGAUGAGGCCGAAAGGCCGAA AUAUAAA                                                                    948                                          1293 AAGUGCA CUGAUGAGGCCGAAAGGCCGAA AUAUAAA                                                                    949                                          1294 UAAGUGC CUGAUGAGGCCGAAAGGCCGAA AAUAUAA                                                                    950                                          1300 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AGUGCAA                                                                    951                                          1303 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAGUG                                                                    952                                          1304 UAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAGU                                                                    953                                          1306 AAUAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                    954                                          1307 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                    955                                          1307 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                    956                                          1308 UAAAUAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                    957                                          1310 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    958                                          1310 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    959                                          1310 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    960                                          1311 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    961                                          1311 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    962                                          1311 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    963                                          1313 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                    964                                          1313 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                    965                                          1313 AUAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAUAA                                                                    966                                          1314 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                    967                                          1314 AAUAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAUA                                                                    968                                          1315 UAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                    969                                          1317 AAUAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    970                                          1318 AAAUAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    971                                          1319 UAAAUAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAA                                                                    972                                          1326 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAU                                                                    973                                          1328 GCAAAUA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    974                                          1329 AGCAAAU CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    975                                          1330 AAGCAAA CUGAUGAGGCCGAAAGGCCGAA AAAUAAA                                                                    976                                          1332 AUAAGCA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    977                                          1333 CAUAAGC CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    978                                          1337 CAUUCAU CUGAUGAGGCCGAAAGGCCGAA AGCAAAU                                                                    979                                          1338 ACAUUCA CUGAUGAGGCCGAAAGGCCGAA AAGCAAA                                                                    980                                          1346 AAAUAAA CUGAUGAGGCCGAAAGGCCGAA ACAUUCA                                                                    981                                          1348 CCAAAUA CUGAUGAGGCCGAAAGGCCGAA AUACAUU                                                                    982                                          1349 UCCAAAU CUGAUGAGGCCGAAAGGCCGAA AAUACAU                                                                    983                                          1350 UUCCAAA CUGAUGAGGCCGAAAGGCCGAA AAAUACA                                                                    984                                          1352 CCUUCCA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    985                                          1352 CCUUCCA CUGAUGAGGCCGAAAGGCCGAA AUAAAUA                                                                    986                                          1353 GCCUUCC CUGAUGAGGCCGAAAGGCCGAA AAUAAAU                                                                    987                                          1369 CCUCCAG CUGAUGAGGCCGAAAGGCCGAA ACACCCC                                                                    988                                          1398 CUGUCUG CUGAUGAGGCCGAAAGGCCGAA AGACAGC                                                                    989                                          1398 CUGUCUG CUGAUGAGGCCGAAAGGCCGAA AGACAGC                                                                    990                                          1412 CACAGAA CUGAUGAGGCCGAAAGGCCGAA ACAUGUC                                                                    991                                          1413 UCACAGA CUGAUGAGGCCGAAAGGCCGAA AACAUGU                                                                    992                                          1414 UUCACAG CUGAUGAGGCCGAAAGGCCGAA AAACAUG                                                                    993                                          1415 UUUCACA CUGAUGAGGCCGAAAGGCCGAA AAAACAU                                                                    994                                          1415 UUUCACA CUGAUGAGGCCGAAAGGCCGAA AAAACAU                                                                    995                                          1438 AGGUGGG CUGAUGAGGCCGAAAGGCCGAA ACAGCUC                                                                    996                                          1451 AGGUAGA CUGAUGAGGCCGAAAGGCCGAA AGGCCAG                                                                    997                                          1453 CAAGGUA CUGAUGAGGCCGAAAGGCCGAA AGAGGCC                                                                    998                                          1455 AACAAGG CUGAUGAGGCCGAAAGGCCGAA AGAGAGG                                                                    999                                          1462 AGGAGGC CUGAUGAGGCCGAAAGGCCGAA ACAAGGU                                                                   1000                                          1470 AGCAAAA CUGAUGAGGCCGAAAGGCCGAA AGGAGGC                                                                   1001                                          1472 UAAGCAA CUGAUGAGGCCGAAAGGCCGAA AGAGGAG                                                                   1002                                          1473 AUAAGCA CUGAUGAGGCCGAAAGGCCGAA AAGAGGA                                                                   1003                                          1474 CAUAAGC CUGAUGAGGCCGAAAGGCCGAA AAAGAGG                                                                   1004                                          1478 UAAACAU CUGAUGAGGCCGAAAGGCCGAA AGCAAAA                                                                   1005                                          1479 UUAAACA CUGAUGAGGCCGAAAGGCCGAA AAGCAAA                                                                   1006                                          1479 UUAAACA CUGAUGAGGCCGAAAGGCCGAA AAGCAAA                                                                   1007                                          1484 UUGUUUU CUGAUGAGGCCGAAAGGCCGAA AACAUAA                                                                   1008                                          1498 GUUAGAU CUGAUGAGGCCGAAAGGCCGAA AAUAUUU                                                                   1009                                          1511 UUAAGAC CUGAUGAGGCCGAAAGGCCGAA AUUGGGU                                                                   1010                                          1514 UUAUUAA CUGAUGAGGCCGAAAGGCCGAA ACAAUUG                                                                   1011                                          1516 CGUUAUU CUGAUGAGGCCGAAAGGCCGAA AGACAAU                                                                   1012                                          1529 GUCACCA CUGAUGAGGCCGAAAGGCCGAA AUCAGCG                                                                   1013                                          1529 GUCACCA CUGAUGAGGCCGAAAGGCCGAA AUCAGCG                                                                   1014                                          1530 GGUCACC CUGAUGAGGCCGAAAGGCCGAA AAUCAGC                                                                   1015                                          1530 GGUCACC CUGAUGAGGCCGAAAGGCCGAA AAUCAGC                                                                   1016                                          1563 GGGAGCA CUGAUGAGGCCGAAAGGCCGAA AGGUUCA                                                                   1017                                          1563 GGGAGCA CUGAUGAGGCCGAAAGGCCGAA AGGUUCA                                                                   1018                                          1568 CCGUGGG CUGAUGAGGCCGAAAGGCCGAA AGCAGAG                                                                   1019                                          1589 GGGCAAU CUGAUGAGGCCGAAAGGCCGAA ACAGUCA                                                                   1020                                          1592 GUAGGGC CUGAUGAGGCCGAAAGGCCGAA AUUACAG                                                                   1021                                          1617 CGAUCUU CUGAUGAGGCCGAAAGGCCGAA AUUUCUC                                                                   1022                                          1623 UUUAAGC CUGAUGAGGCCGAAAGGCCGAA AUCUUUA                                                                   1023                                          1633 GGUUUUU CUGAUGAGGCCGAAAGGCCGAA AUUUUAA                                                                   1024                                          __________________________________________________________________________

                                      TABLE VI                                    __________________________________________________________________________    Human TNF-a Hairpin Ribozyme Sequences                                        nt.                                         Sequence      Sequence            Position                                                                          Hairpin Ribozyme Sequence               ID No.                                                                             Substrate                                                                              ID                  __________________________________________________________________________                                                              No.                  46 AGCCGUGG AGAA GUAUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1025 ACAUACU                                                                                1058                                                                 CCACGGCU                      54 GAGGGUGG AGAA GUGGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1026 ACCCACG                                                                                1059                                                                 CCACCCUC                      185                                                                              GGAGAAGA AGAA GAGGAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1027 UUCCUCA                                                                                1060                                                                 UCUUCUCC                      201                                                                              CUGCCACG AGAA GGAAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1028 CCUUCCU                                                                                1061                                                                 CGUGGCAG                      230                                                                              GUGCAGCA AGAA GAAGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1029 CUCUUCU                                                                                1062                                                                 UGCUGCAC                      234                                                                              CAAAGUGC AGAA GGCAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1030 UCUGCCU                                                                                1063                                                                 GCACUUUG                      254                                                                              CCUCUGGG AGAA GAUCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1031 GUGAUCG                                                                                1064                                                                 CCCAGAGG                      296                                                                              GGCCAGAG AGAA GAUUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1032 CUAAUCA                                                                                1065                                                                 CUCUGGCC                      317                                                                              AGAAGAUG AGAA GACUGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1033 GCAGUCA                                                                                1066                                                                 CAUCUUCU                      387                                                                              GCCACUGG AGAA GCCCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1034 AGGGGCA                                                                                1067                                                                 CCAGUGGC                      404                                                                              AUUGGCCC AGAA GUUCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1035 CUGAACC                                                                                1068                                                                 GGGCCAAU                      453                                                                              GCACCACC AGAA GGUUAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1036 AUAACCA                                                                                1069                                                                 GGUGGUGC                      518                                                                              GGUGGAGG AGAA GCCUUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1037 CAAGGCU                                                                                1070                                                                 CCUCCACC                      554                                                                              GGCGAUGC AGAA GAUGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1038 ACCAUCA                                                                                1071                                                                 GCAUCGCC                      565                                                                              UGGUAGGA AGAA GCGAUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1039 CAUCGCC                                                                                1072                                                                 UCCUACCA                      576                                                                              UGACCUUG AGAA GGUAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1040 CCUACCA                                                                                1073                                                                 CAAGGUCA                      687                                                                              CCUUCUCC AGAA GGAAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1041 UCUUCCA                                                                                1074                                                                 GGAGAAGG                      704                                                                              AGCGCUGA AGAA GUCACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1042 GGUGACC                                                                                1075                                                                 UCAGCGCU                      726                                                                              GAUAGUCG AGAA GAUUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1043 UCAAUCG                                                                                1076                                                                 CGACUAUC                      730                                                                              UCGAGAUA AGAA GGCCGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1044 UCGGCCC                                                                                1077                                                                 UAUCUCGA                      824                                                                              GGGAUUGG AGAA GGGGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1045 CUCCCCU                                                                                1078                                                                 CCAAUCCC                     1042                                                                              GGGAUCAA AGAA GUAGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1046 GCCUACA                                                                                1079                                                                 UUGAUCCC                     1168                                                                              CUGGAAAC AGAA GGAGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1047 CUCUCCA                                                                                1080                                                                 GUUUCCAG                     1178                                                                              UCAAGGAA AGGA GGAAAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1048 GUUUCCA                                                                                1081                                                                 UUCCUUGA                     1202                                                                              AUGGGGAG AGAA GGGCUC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1049 GAGCCCA                                                                                1082                                                                 CUCCCCAU                     1220                                                                              AUAGAGGG AGAA GGCUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1050 GGAGCCA                                                                                1083                                                                 CCCUCUAU                     1284                                                                              AUACAUUC AGAA GUAAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1051 AUUUACA                                                                                1084                                                                 GAAUGUAU                     1340                                                                              UGAGCCAA AGAA GCUCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1052 AGGAGCU                                                                                1085                                                                 UUGGCUCA                     1390                                                                              UACAUGGG AGAA GCCUAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1053 AUAGGCU                                                                                1086                                                                 CCCAUGUA                     1452                                                                              ACAACUUA AGAA GAUAAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1054 AUUAUCU                                                                                1087                                                                 UAAGUUGU                     1475                                                                              GUCACCAA AGAA GCAUUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1055 CAAUGCU                                                                                1088                                                                 UUGGUGAC                     1513                                                                              CCCUGGGG AGAA GAGGCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1056 GGCCUCU                                                                                1089                                                                 CCCCAGGG                     1541                                                                              GAAUAGUA AGAA GAUUAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1057 GUAAUCG                                                                                1090                                                                 UACUAUUC                     __________________________________________________________________________

                                      TABLE VII                                   __________________________________________________________________________    Mouse TNF-a Hairpin Ribozyme Sequences                                                                                    Sequence      Sequence            nt. Hairpin Ribozyme Sequence               ID No.                                                                              Substrate                                                                             ID                  __________________________________________________________________________                                                              No.                  103                                                                              GUGAAAGG AGAA GAACCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1091  AGGUUCU                                                                               1124                                                                  CCUUUCAC                     256                                                                              UGAGAAGA AGAA GAGACA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1092  UGUCUCA                                                                               1125                                                                  UCUUCUCA                     272                                                                              CUGCCACA AGAA GGAAUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1093  CAUUCCU                                                                               1126                                                                  UGUGGCAG                     301                                                                              GUUCAGUA AGAA GAAGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1094  CUCUUCU                                                                               1127                                                                  UACUGAAC                     325                                                                              CCUUUGGG AGAA GAUCAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1095  GUGAUCG                                                                               1128                                                                  CCCAAAGG                     370                                                                              GGCCAUAG AGAA GAUGAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1096  CUCAUCA                                                                               1129                                                                  CUAUGGCC                     383                                                                              GUGUGAGG AGAA GGGCCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1097  UGGCCCA                                                                               1130                                                                  CCUCACAC                     397                                                                              AGAAGAUG AGAA GAGUGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1098  ACACUCA                                                                               1131                                                                  CAUCUUCU                     467                                                                              GCCACUCC AGAA GCUCCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1099  AGGAGCA                                                                               1132                                                                  GGAGUGGC                     546                                                                              AACCCAUC AGAA GGCACC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1100  GGUGCCA                                                                               1133                                                                  GAUGGGUU                     549                                                                              UACAACCC AGAA GCUGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1101  GCCAGCC                                                                               1134                                                                  GGGUUGUA                     598                                                                              GUAGUCGG AGAA GCCUUG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1102  CAAGGCU                                                                               1135                                                                  CCGACUAC                     603                                                                              AGCACGUA AGAA GGGCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1103  CUGCCCC                                                                               1136                                                                  UACGUGCU                     631                                                                              AGCAAAUC AGAA GACGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1104  ACCGUCA                                                                               1137                                                                  GAUUUGCU                     634                                                                              GAUAGCAA AGAA GCUGAC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1105  GUCAGCC                                                                               1138                                                                  UUGCUAUC                     675                                                                              CUCUUGAC AGAA GAGAGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1106  CCUCUCU                                                                               1139                                                                  GUCAAGAG                     691                                                                              GUCCUUGG AGAA GGGGCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1107  AGCCCCU                                                                               1140                                                                  CCAAGGAC                     764                                                                              CCUUCUCC AGAA GGAAGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1108  UCUUCCA                                                                               1141                                                                  GGAGAAGG                     803                                                                              AGUACUUG AGAA GAUUGA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1109  UCAAUCU                                                                               1142                                                                  CAAGUACU                     895                                                                              AGAGUGGG AGAA GGGUAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1110  CUACCCA                                                                               1143                                                                  CCCACUCU                     906                                                                              GUAAAGGG AGAA GAGUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1111  CCACUCU                                                                               1144                                                                  CCCUUUAC                     920                                                                              AUAAAGGG AGAA GAGUAA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1112  UUACUCU                                                                               1145                                                                  CCCUUUAU                     953                                                                              AGGACACA AGAA GGGGGC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1113  GCCCCCA                                                                               1146                                                                  UGUGUCCU                    1175                                                                              CAUUCUGA AGAA GAGGCA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1114  UGCCUCU                                                                               1147                                                                  UCAGAAUG                    1220                                                                              CUGGAAAG AGAA GAAGGU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1115  ACCUUCA                                                                               1148                                                                  CUUUCCAG                    1230                                                                              AGGGAAGA AGAA GGAAAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1116  CUUUCCA                                                                               1149                                                                  UCUUCCCU                    1256                                                                              GUGAGGAA AGAA GUGCAU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1117  AUGCACA                                                                               1150                                                                  UUCCUCAC                    1274                                                                              UAGAGGGG AGAA GGCUCU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1118  AGAGCCA                                                                               1151                                                                  CCCCUCUA                    1393                                                                              UGUCUGAA AGAA GCUUCC ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1119  GGAAGCU                                                                               1152                                                                  UUCAGACA                    1435                                                                              CAGGUGGG AGAA GCUCAG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1120  CUGAGCU                                                                               1153                                                                  CCCACCUG                    1525                                                                              GUCACCAA AGAA GCGUUA ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1121  UAACGCU                                                                               1154                                                                  UUGGUGAC                    1542                                                                              GAUGUAGC AGAA GCCUGG ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1122  CCAGGCU                                                                               1155                                                                  GCUACAUC                    1564                                                                              CCGUGGGG AGAA GAGGUU ACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA                                                             1123  AACCUCU                                                                               1156                                                                  CCCCACGG                    __________________________________________________________________________

    __________________________________________________________________________    SEQUENCE LISTING                                                              (1) GENERAL INFORMATION:                                                      (iii) NUMBER OF SEQUENCES: 1157                                               (2) INFORMATION FOR SEQ ID NO: 1:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 11                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for                               any base. "H"represents                                                       nucleotide C, A, or U.                                                        (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 1:                                      NNNNUHNNNNN11                                                                 (2) INFORMATION FOR SEQ ID NO: 2:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 28                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for                               any base.                                                                     (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2:                                      NNNNNCUGANGAGNNNNNNCGAAANNNN28                                                (2) INFORMATION FOR SEQ ID NO: 3:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 14                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for                               any base. The leter "Y"is                                                     U or C. The letter "H"is                                                      A, U, or C.                                                                   (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3:                                      NNNYNGHYNNNNNN14                                                              (2) INFORMATION FOR SEQ ID NO: 4:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 50                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (ix) FEATURE:                                                                 (D) OTHER INFORMATION: The letter "N"stands for                               any base.                                                                     (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4:                                      NNNNNNNGAAGNNNNNNNNNNAAACANNNNNNNNNNNACAUUACNNNNNN50                          (2) INFORMATION FOR SEQ ID NO: 5:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 85                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5:                                      UGGCCGGCAUGGUCCCAGCCUCCUCGCUGGCGCCGGCUGGGCAACAUUCCGAGGGGACCG60                UCCCCUCGGUAAUGGCGAAUGGGAC85                                                   (2) INFORMATION FOR SEQ ID NO: 6:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 176                                                               (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6:                                      GGGAAAGCUUGCGAAGGGCGUCGUCGCCCCGAGCGGUAGUAAGCAGGGAACUCACCUCCA60                AUUUCAGUACUGAAAUUGUCGUAGCAGUUGACUACUGUUAUGUGAUUGGUAGAGGCUAAG120               UGACGGUAUUGGCGUAAGUCAGUAUUGCAGCACAGCACAAGCCCGCUUGCGAGAAU176                   (2) INFORMATION FOR SEQ ID NO: 7:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7:                                      GGAAGCUGUCUUCAGACA18                                                          (2) INFORMATION FOR SEQ ID NO: 8:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8:                                      UGUCUGAAAGAAGCUUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO: 9:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9:                                      GGAAGCUGUCUUCAGACA18                                                          (2) INFORMATION FOR SEQ ID NO: 10:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10:                                     UGUCUGAAAUAAGCUUCCACCAGAGAAAGACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO: 11:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:                                     CUGAGCUGUCCCCACCUG18                                                          (2) INFORMATION FOR SEQ ID NO: 12:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12:                                     CAGGUGGGAGAAGCUCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO: 13:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13:                                     CUGAGCUGUCCCCACCUG18                                                          (2) INFORMATION FOR SEQ ID NO: 14:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54                                                                (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14:                                     CAGGUGGGAUAAGCUCAGACCAGAGAAAGACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:15:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:15:                                      GGCAGGUUCUCUUCC15                                                             (2) INFORMATION FOR SEQ ID NO:16:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:16:                                      GCAGGUUCUCUUCCU15                                                             (2) INFORMATION FOR SEQ ID NO:17:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:17:                                      AGGUUCUCUUCCUCU15                                                             (2) INFORMATION FOR SEQ ID NO:18:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:18:                                      GUUCUCUUCCUCUCA15                                                             (2) INFORMATION FOR SEQ ID NO:19:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:19:                                      UUCUCUUCCUCUCAC15                                                             (2) INFORMATION FOR SEQ ID NO:20:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:20:                                      UCUUCCUCUCACAUA15                                                             (2) INFORMATION FOR SEQ ID NO:21:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:21:                                      UUCCUCUCACAUACU15                                                             (2) INFORMATION FOR SEQ ID NO:22:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:22:                                      CUCACAUACUGACCC15                                                             (2) INFORMATION FOR SEQ ID NO:23:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:23:                                      CACGGCUCCACCCUC15                                                             (2) INFORMATION FOR SEQ ID NO:24:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:24:                                      CCACCCUCUCUCCCC15                                                             (2) INFORMATION FOR SEQ ID NO:25:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:                                      ACCCUCUCUCCCCUG15                                                             (2) INFORMATION FOR SEQ ID NO:26:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:26:                                      CCUCUCUCCCCUGGA15                                                             (2) INFORMATION FOR SEQ ID NO:27:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:27:                                      GCAUGAUCCGGGACG15                                                             (2) INFORMATION FOR SEQ ID NO:28:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:28:                                      AGGCGCUCCCCAAGA15                                                             (2) INFORMATION FOR SEQ ID NO:29:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:29:                                      CAGGGCUCCAGGCGG15                                                             (2) INFORMATION FOR SEQ ID NO:30:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:30:                                      CGGUGCUUGUUCCUC15                                                             (2) INFORMATION FOR SEQ ID NO:31:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:31:                                      UGCUUGUUCCUCAGC15                                                             (2) INFORMATION FOR SEQ ID NO:32:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:32:                                      GCUUGUUCCUCAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:33:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:                                      UGUUCCUCAGCCUCU15                                                             (2) INFORMATION FOR SEQ ID NO:34:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:34:                                      UCAGCCUCUUCUCCU15                                                             (2) INFORMATION FOR SEQ ID NO:35:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:35:                                      AGCCUCUUCUCCUUC15                                                             (2) INFORMATION FOR SEQ ID NO:36:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:36:                                      GCCUCUUCUCCUUCC15                                                             (2) INFORMATION FOR SEQ ID NO:37:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:37:                                      CUCUUCUCCUUCCUG15                                                             (2) INFORMATION FOR SEQ ID NO:38:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:38:                                      UUCUCCUUCCUGAUC15                                                             (2) INFORMATION FOR SEQ ID NO:39:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:39:                                      UCUCCUUCCUGAUCG15                                                             (2) INFORMATION FOR SEQ ID NO:40:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:40:                                      UCCUGAUCGUGGCAG15                                                             (2) INFORMATION FOR SEQ ID NO:41:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:41:                                      CCACGCUCUUCUGCC15                                                             (2) INFORMATION FOR SEQ ID NO:42:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:42:                                      ACGCUCUUCUGCCUG15                                                             (2) INFORMATION FOR SEQ ID NO:43:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43:                                      CGCUCUUCUGCCUGC15                                                             (2) INFORMATION FOR SEQ ID NO:44:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:44:                                      CUGCACUUUGGAGUG15                                                             (2) INFORMATION FOR SEQ ID NO:45:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:45:                                      UGCACUUUGGAGUGA15                                                             (2) INFORMATION FOR SEQ ID NO:46:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46:                                      GAGUGAUCGGCCCCC15                                                             (2) INFORMATION FOR SEQ ID NO:47:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:47:                                      GAAGAGUCCCCCAGG15                                                             (2) INFORMATION FOR SEQ ID NO:48:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:48:                                      GGGACCUCUCUCUAA15                                                             (2) INFORMATION FOR SEQ ID NO:49:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:49:                                      GACCUCUCUCUAAUC15                                                             (2) INFORMATION FOR SEQ ID NO:50:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:50:                                      CCUCUCUCUAAUCAG15                                                             (2) INFORMATION FOR SEQ ID NO:51:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:51:                                      UCUCUCUAAUCAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:52:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:52:                                      CUCUAAUCAGCCCUC15                                                             (2) INFORMATION FOR SEQ ID NO:53:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:53:                                      CAGCCCUCUGGCCCA15                                                             (2) INFORMATION FOR SEQ ID NO:54:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:54:                                      GUCAGAUCAUCUUCU15                                                             (2) INFORMATION FOR SEQ ID NO:55:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:55:                                      AGAUCAUCUUCUCGA15                                                             (2) INFORMATION FOR SEQ ID NO:56:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:56:                                      AUCAUCUUCUCGAAC15                                                             (2) INFORMATION FOR SEQ ID NO:57:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:57:                                      UCAUCUUCUCGAACC15                                                             (2) INFORMATION FOR SEQ ID NO:58:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:58:                                      AUCUUCUCGAACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:59:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:59:                                      AGCCUGUAGCCCAUG15                                                             (2) INFORMATION FOR SEQ ID NO:60:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:60:                                      CCCAUGUUGUAGCAA15                                                             (2) INFORMATION FOR SEQ ID NO:61:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:61:                                      AUGUUGUAGCAAACC15                                                             (2) INFORMATION FOR SEQ ID NO:62:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:62:                                      AAACCCUCAAGCUGA15                                                             (2) INFORMATION FOR SEQ ID NO:63:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:63:                                      GGCAGCUCCAGUGGC15                                                             (2) INFORMATION FOR SEQ ID NO:64:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:64:                                      AUGCCCUCCUGGCCA15                                                             (2) INFORMATION FOR SEQ ID NO:65:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:65:                                      GAGAGAUAACCAGCU15                                                             (2) INFORMATION FOR SEQ ID NO:66:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:66:                                      GUGCCAUCAGAGGGC15                                                             (2) INFORMATION FOR SEQ ID NO:67:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:67:                                      GGCCUGUACCUCAUC15                                                             (2) INFORMATION FOR SEQ ID NO:68:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:68:                                      UGUACCUCAUCUACU15                                                             (2) INFORMATION FOR SEQ ID NO:69:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:69:                                      ACCUCAUCUACUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:70:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:70:                                      CUCAUCUACUCCCAG15                                                             (2) INFORMATION FOR SEQ ID NO:71:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:71:                                      AUCUACUCCCAGGUC15                                                             (2) INFORMATION FOR SEQ ID NO:72:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:72:                                      CCCAGGUCCUCUUCA15                                                             (2) INFORMATION FOR SEQ ID NO:73:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:73:                                      AGGUCCUCUUCAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:74:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:74:                                      GUCCUCUUCAAGGGC15                                                             (2) INFORMATION FOR SEQ ID NO:75:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:75:                                      UCCUCUUCAAGGGCC15                                                             (2) INFORMATION FOR SEQ ID NO:76:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:76:                                      UGCCCCUCCACCCAU15                                                             (2) INFORMATION FOR SEQ ID NO:77:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:77:                                      AUGUGCUCCUCACCC15                                                             (2) INFORMATION FOR SEQ ID NO:78:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:78:                                      UGCUCCUCACCCACA15                                                             (2) INFORMATION FOR SEQ ID NO:79:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:79:                                      ACACCAUCAGCCGCA15                                                             (2) INFORMATION FOR SEQ ID NO:80:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:80:                                      GCCGCAUCGCCGUCU15                                                             (2) INFORMATION FOR SEQ ID NO:81:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:81:                                      UCGCCGUCUCCUACC15                                                             (2) INFORMATION FOR SEQ ID NO:82:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:82:                                      GCCGUCUCCUACCAG15                                                             (2) INFORMATION FOR SEQ ID NO:83:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:83:                                      GUCUCCUACCAGACC15                                                             (2) INFORMATION FOR SEQ ID NO:84:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:84:                                      CCAAGGUCAACCUCC15                                                             (2) INFORMATION FOR SEQ ID NO:85:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:85:                                      UCAACCUCCUCUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:86:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:86:                                      ACCUCCUCUCUGCCA15                                                             (2) INFORMATION FOR SEQ ID NO:87:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:87:                                      CUCCUCUCUGCCAUC15                                                             (2) INFORMATION FOR SEQ ID NO:88:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:88:                                      CUGCCAUCAAGAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:89:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:89:                                      CCCUGGUAUGAGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:90:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:90:                                      AGCCCAUCUAUCUGG15                                                             (2) INFORMATION FOR SEQ ID NO:91:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:91:                                      CCCAUCUAUCUGGGA15                                                             (2) INFORMATION FOR SEQ ID NO:92:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:92:                                      CAUCUAUCUGGGAGG15                                                             (2) INFORMATION FOR SEQ ID NO:93:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:93:                                      GAGGGGUCUUCCAGC15                                                             (2) INFORMATION FOR SEQ ID NO:94:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:94:                                      GGGGUCUUCCAGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:95:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:95:                                      GGGUCUUCCAGCUGG15                                                             (2) INFORMATION FOR SEQ ID NO:96:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:96:                                      ACCGACUCAGCGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:97:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:97:                                      CUGAGAUCAAUCGGC15                                                             (2) INFORMATION FOR SEQ ID NO:98:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:98:                                      GAUCAAUCGGCCCGA15                                                             (2) INFORMATION FOR SEQ ID NO:99:                                             (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:99:                                      CCCGACUAUCUCGAC15                                                             (2) INFORMATION FOR SEQ ID NO:100:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:100:                                     CGACUAUCUCGACUU15                                                             (2) INFORMATION FOR SEQ ID NO:101:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:101:                                     ACUAUCUCGACUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:102:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:102:                                     CUCGACUUUGCCGAG15                                                             (2) INFORMATION FOR SEQ ID NO:103:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:103:                                     UCGACUUUGCCGAGU15                                                             (2) INFORMATION FOR SEQ ID NO:104:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:104:                                     GCCGAGUCUGGGCAG15                                                             (2) INFORMATION FOR SEQ ID NO:105:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:105:                                     GGCAGGUCUACUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:106:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:106:                                     CAGGUCUACUUUGGG15                                                             (2) INFORMATION FOR SEQ ID NO:107:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:107:                                     GUCUACUUUGGGAUC15                                                             (2) INFORMATION FOR SEQ ID NO:108:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:108:                                     UCUACUUUGGGAUCA15                                                             (2) INFORMATION FOR SEQ ID NO:109:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:109:                                     UUGGGAUCAUUGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:110:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:110:                                     GGAUCAUUGCCCUGU15                                                             (2) INFORMATION FOR SEQ ID NO:111:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:111:                                     CGAACAUCCAACCUU15                                                             (2) INFORMATION FOR SEQ ID NO:112:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:112:                                     CCAACCUUCCCAAAC15                                                             (2) INFORMATION FOR SEQ ID NO:113:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:113:                                     CAACCUUCCCAAACG15                                                             (2) INFORMATION FOR SEQ ID NO:114:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:114:                                     AACGCCUCCCCUGCC15                                                             (2) INFORMATION FOR SEQ ID NO:115:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:115:                                     CCCCAAUCCCUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:116:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:116:                                     AAUCCCUUUAUUACC15                                                             (2) INFORMATION FOR SEQ ID NO:117:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:117:                                     AUCCCUUUAUUACCC15                                                             (2) INFORMATION FOR SEQ ID NO:118:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:118:                                     UCCCUUUAUUACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:119:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:119:                                     CCUUUAUUACCCCCU15                                                             (2) INFORMATION FOR SEQ ID NO:120:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:120:                                     CUUUAUUACCCCCUC15                                                             (2) INFORMATION FOR SEQ ID NO:121:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:121:                                     ACCCCCUCCUUCAGA15                                                             (2) INFORMATION FOR SEQ ID NO:122:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:122:                                     CCCUCCUUCAGACAC15                                                             (2) INFORMATION FOR SEQ ID NO:123:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:123:                                     CCUCCUUCAGACACC15                                                             (2) INFORMATION FOR SEQ ID NO:124:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:124:                                     ACACCCUCAACCUCU15                                                             (2) INFORMATION FOR SEQ ID NO:125:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:125:                                     UCAACCUCUUCUGGC15                                                             (2) INFORMATION FOR SEQ ID NO:126:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:126:                                     AACCUCUUCUGGCUC15                                                             (2) INFORMATION FOR SEQ ID NO:127:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:127:                                     ACCUCUUCUGGCUCA15                                                             (2) INFORMATION FOR SEQ ID NO:128:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:128:                                     UCUGGCUCAAAAAGA15                                                             (2) INFORMATION FOR SEQ ID NO:129:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:129:                                     AGAGAAUUGGGGGCU15                                                             (2) INFORMATION FOR SEQ ID NO:130:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:130:                                     GGGGGCUUAGGGUCG15                                                             (2) INFORMATION FOR SEQ ID NO:131:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:131:                                     GGGGCUUAGGGUCGG15                                                             (2) INFORMATION FOR SEQ ID NO:132:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:132:                                     UUAGGGUCGGAACCC15                                                             (2) INFORMATION FOR SEQ ID NO:133:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:133:                                     CCAAGCUUAGAACUU15                                                             (2) INFORMATION FOR SEQ ID NO:134:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:134:                                     CAAGCUUAGAACUUU15                                                             (2) INFORMATION FOR SEQ ID NO:135:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:135:                                     UAGAACUUUAAGCAA15                                                             (2) INFORMATION FOR SEQ ID NO:136:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:136:                                     AGAACUUUAAGCAAC15                                                             (2) INFORMATION FOR SEQ ID NO:137:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:137:                                     GAACUUUAAGCAACA15                                                             (2) INFORMATION FOR SEQ ID NO:138:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:138:                                     CACCACUUCGAAACC15                                                             (2) INFORMATION FOR SEQ ID NO:139:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:139:                                     ACCACUUCGAAACCU15                                                             (2) INFORMATION FOR SEQ ID NO:140:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:140:                                     CUGGGAUUCAGGAAU15                                                             (2) INFORMATION FOR SEQ ID NO:141:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:141:                                     UGGGAUUCAGGAAUG15                                                             (2) INFORMATION FOR SEQ ID NO:142:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:142:                                     AACCACUAAGAAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:143:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:143:                                     UAAGAAUUCAAACUG15                                                             (2) INFORMATION FOR SEQ ID NO:144:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:144:                                     AAGAAUUCAAACUGG15                                                             (2) INFORMATION FOR SEQ ID NO:145:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:145:                                     GGGGCCUCCAGAACU15                                                             (2) INFORMATION FOR SEQ ID NO:146:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:146:                                     CAGAACUCACUGGGG15                                                             (2) INFORMATION FOR SEQ ID NO:147:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:147:                                     GGGGCCUACAGCUUU15                                                             (2) INFORMATION FOR SEQ ID NO:148:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:148:                                     UACAGCUUUGAUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:149:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:149:                                     ACAGCUUUGAUCCCU15                                                             (2) INFORMATION FOR SEQ ID NO:150:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:150:                                     CUUUGAUCCCUGACA15                                                             (2) INFORMATION FOR SEQ ID NO:151:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:151:                                     CUGACAUCUGGAAUC15                                                             (2) INFORMATION FOR SEQ ID NO:152:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:152:                                     CUGGAAUCUGGAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:153:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:153:                                     GGAGCCUUUGGUUCU15                                                             (2) INFORMATION FOR SEQ ID NO:154:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:154:                                     GAGCCUUUGGUUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:155:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:155:                                     CUUUGGUUCUGGCCA15                                                             (2) INFORMATION FOR SEQ ID NO:156:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:156:                                     UUUGGUUCUGGCCAG15                                                             (2) INFORMATION FOR SEQ ID NO:157:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:157:                                     CAGGACUUGAGAAGA15                                                             (2) INFORMATION FOR SEQ ID NO:158:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:158:                                     AAGACCUCACCUAGA15                                                             (2) INFORMATION FOR SEQ ID NO:159:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:159:                                     CUCACCUAGAAAUUG15                                                             (2) INFORMATION FOR SEQ ID NO:160:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:160:                                     UAGAAAUUGACACAA15                                                             (2) INFORMATION FOR SEQ ID NO:161:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:161:                                     UGGACCUUAGGCCUU15                                                             (2) INFORMATION FOR SEQ ID NO:162:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:162:                                     GGACCUUAGGCCUUC15                                                             (2) INFORMATION FOR SEQ ID NO:163:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:163:                                     UAGGCCUUCCUCUCU15                                                             (2) INFORMATION FOR SEQ ID NO:164:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:164:                                     AGGCCUUCCUCUCUC15                                                             (2) INFORMATION FOR SEQ ID NO:165:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:165:                                     CCUUCCUCUCUCCAG15                                                             (2) INFORMATION FOR SEQ ID NO:166:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:166:                                     UUCCUCUCUCCAGAU15                                                             (2) INFORMATION FOR SEQ ID NO:167:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:167:                                     CCUCUCUCCAGAUGU15                                                             (2) INFORMATION FOR SEQ ID NO:168:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:168:                                     CAGAUGUUUCCAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:169:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:169:                                     AGAUGUUUCCAGACU15                                                             (2) INFORMATION FOR SEQ ID NO:170:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:170:                                     GAUGUUUCCAGACUU15                                                             (2) INFORMATION FOR SEQ ID NO:171:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:171:                                     CCAGACUUCCUUGAG15                                                             (2) INFORMATION FOR SEQ ID NO:172:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:172:                                     CAGACUUCCUUGAGA15                                                             (2) INFORMATION FOR SEQ ID NO:173:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:173:                                     ACUUCCUUGAGACAC15                                                             (2) INFORMATION FOR SEQ ID NO:174:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:174:                                     CAGCCCUCCCCAUGG15                                                             (2) INFORMATION FOR SEQ ID NO:175:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:175:                                     GCCAGCUCCCUCUAU15                                                             (2) INFORMATION FOR SEQ ID NO:176:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:176:                                     GCUCCCUCUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:177:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:177:                                     UCCCUCUAUUUAUGU15                                                             (2) INFORMATION FOR SEQ ID NO:178:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:178:                                     CCUCUAUUUAUGUUU15                                                             (2) INFORMATION FOR SEQ ID NO:179:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:179:                                     CUCUAUUUAUGUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:180:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:180:                                     UCUAUUUAUGUUUGC15                                                             (2) INFORMATION FOR SEQ ID NO:181:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:181:                                     UUUAUGUUUGCACUU15                                                             (2) INFORMATION FOR SEQ ID NO:182:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:182:                                     UUAUGUUUGCACUUG15                                                             (2) INFORMATION FOR SEQ ID NO:183:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:183:                                     UUGCACUUGUGAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:184:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:184:                                     UUGUGAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:185:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:185:                                     UGUGAUUAUUUAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:186:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:186:                                     UGAUUAUUUAUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:187:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:187:                                     GAUUAUUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:188:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:188:                                     AUUAUUUAUUAUUUA15                                                             (2) INFORMATION FOR SEQ ID NO:189:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:189:                                     UAUUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:190:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:190:                                     AUUUAUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:191:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:191:                                     UUAUUAUUUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:192:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:192:                                     UAUUAUUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:193:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:193:                                     AUUAUUUAUUUAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:194:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:194:                                     UAUUUAUUUAUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:195:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:195:                                     AUUUAUUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:196:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:196:                                     UUUAUUUAUUAUUUA15                                                             (2) INFORMATION FOR SEQ ID NO:197:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:197:                                     UAUUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:198:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:198:                                     AUUUAUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:199:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:199:                                     UUAUUAUUUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:200:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:200:                                     UAUUAUUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:201:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:201:                                     AUUAUUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:202:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:202:                                     UAUUUAUUUAUUUAC15                                                             (2) INFORMATION FOR SEQ ID NO:203:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:203:                                     AUUUAUUUAUUUACA15                                                             (2) INFORMATION FOR SEQ ID NO:204:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:204:                                     UUUAUUUAUUUACAG15                                                             (2) INFORMATION FOR SEQ ID NO:205:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:205:                                     UAUUUAUUUACAGAU15                                                             (2) INFORMATION FOR SEQ ID NO:206:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:206:                                     AUUUAUUUACAGAUG15                                                             (2) INFORMATION FOR SEQ ID NO:207:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:207:                                     UUUAUUUACAGAUGA15                                                             (2) INFORMATION FOR SEQ ID NO:208:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:208:                                     UGAAUGUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:209:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:209:                                     AAUGUAUUUAUUUGG15                                                             (2) INFORMATION FOR SEQ ID NO:210:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:210:                                     AUGUAUUUAUUUGGG15                                                             (2) INFORMATION FOR SEQ ID NO:211:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:211:                                     UGUAUUUAUUUGGGA15                                                             (2) INFORMATION FOR SEQ ID NO:212:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:212:                                     UAUUUAUUUGGGAGA15                                                             (2) INFORMATION FOR SEQ ID NO:213:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:213:                                     AUUUAUUUGGGAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:214:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:214:                                     CCGGGGUAUCCUGGG15                                                             (2) INFORMATION FOR SEQ ID NO:215:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:215:                                     GGGGUAUCCUGGGGG15                                                             (2) INFORMATION FOR SEQ ID NO:216:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:216:                                     CCAAUGUAGGAGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:217:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:217:                                     GCUGCCUUGGCUCAG15                                                             (2) INFORMATION FOR SEQ ID NO:218:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:218:                                     CUUGGCUCAGACAUG15                                                             (2) INFORMATION FOR SEQ ID NO:219:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:219:                                     GACAUGUUUUCCGUG15                                                             (2) INFORMATION FOR SEQ ID NO:220:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:220:                                     ACAUGUUUUCCGUGA15                                                             (2) INFORMATION FOR SEQ ID NO:221:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:221:                                     CAUGUUUUCCGUGAA15                                                             (2) INFORMATION FOR SEQ ID NO:222:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:222:                                     AUGUUUUCCGUGAAA15                                                             (2) INFORMATION FOR SEQ ID NO:223:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:223:                                     GAACAAUAGGCUGUU15                                                             (2) INFORMATION FOR SEQ ID NO:224:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:224:                                     AGGCUGUUCCCAUGU15                                                             (2) INFORMATION FOR SEQ ID NO:225:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:225:                                     GGCUGUUCCCAUGUA15                                                             (2) INFORMATION FOR SEQ ID NO:226:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:226:                                     CCCAUGUAGCCCCCU15                                                             (2) INFORMATION FOR SEQ ID NO:227:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:227:                                     CUGGCCUCUGUGCCU15                                                             (2) INFORMATION FOR SEQ ID NO:228:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:228:                                     UGUGCCUUCUUUUGA15                                                             (2) INFORMATION FOR SEQ ID NO:229:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:229:                                     GUGCCUUCUUUUGAU15                                                             (2) INFORMATION FOR SEQ ID NO:230:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:230:                                     GCCUUCUUUUGAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:231:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:231:                                     CCUUCUUUUGAUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:232:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:232:                                     CUUCUUUUGAUUAUG15                                                             (2) INFORMATION FOR SEQ ID NO:233:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:233:                                     UUUUGAUUAUGUUUU15                                                             (2) INFORMATION FOR SEQ ID NO:234:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:234:                                     UUUGAUUAUGUUUUU15                                                             (2) INFORMATION FOR SEQ ID NO:235:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:235:                                     AUUAUGUUUUUUAAA15                                                             (2) INFORMATION FOR SEQ ID NO:236:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:236:                                     UUAUGUUUUUUAAAA15                                                             (2) INFORMATION FOR SEQ ID NO:237:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:237:                                     UAUGUUUUUUAAAAU15                                                             (2) INFORMATION FOR SEQ ID NO:238:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:238:                                     UGUUUUUUAAAAUAU15                                                             (2) INFORMATION FOR SEQ ID NO:239:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:239:                                     GUUUUUUAAAAUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:240:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:240:                                     UUAAAAUAUUAUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:241:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:241:                                     AAAAUAUUAUCUGAU15                                                             (2) INFORMATION FOR SEQ ID NO:242:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:242:                                     AAAUAUUAUCUGAUU15                                                             (2) INFORMATION FOR SEQ ID NO:243:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:243:                                     AUAUUAUCUGAUUAA15                                                             (2) INFORMATION FOR SEQ ID NO:244:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:244:                                     AUCUGAUUAAGUUGU15                                                             (2) INFORMATION FOR SEQ ID NO:245:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:245:                                     UCUGAUUAAGUUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:246:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:246:                                     AUUAAGUUGUCUAAA15                                                             (2) INFORMATION FOR SEQ ID NO:247:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:247:                                     AAGUUGUCUAAACAA15                                                             (2) INFORMATION FOR SEQ ID NO:248:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:248:                                     GUUGUCUAAACAAUG15                                                             (2) INFORMATION FOR SEQ ID NO:249:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:249:                                     UGCUGAUUUGGUGAC15                                                             (2) INFORMATION FOR SEQ ID NO:250:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:250:                                     GCUGAUUUGGUGACC15                                                             (2) INFORMATION FOR SEQ ID NO:251:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:251:                                     CAACUGUCACUCAUU15                                                             (2) INFORMATION FOR SEQ ID NO:252:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:252:                                     UGUCACUCAUUGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:253:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:253:                                     CACUCAUUGCUGAGG15                                                             (2) INFORMATION FOR SEQ ID NO:254:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:254:                                     GAGGCCUCUGCUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:255:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:255:                                     CUCUGCUCCCCAGGG15                                                             (2) INFORMATION FOR SEQ ID NO:256:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:256:                                     AGGGAGUUGUGUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:257:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:257:                                     GUUGUGUCUGUAAUC15                                                             (2) INFORMATION FOR SEQ ID NO:258:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:258:                                     UGUCUGUAAUCGGCC15                                                             (2) INFORMATION FOR SEQ ID NO:259:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:259:                                     CUGUAAUCGGCCUAC15                                                             (2) INFORMATION FOR SEQ ID NO:260:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:260:                                     UCGGCCUACUAUUCA15                                                             (2) INFORMATION FOR SEQ ID NO:261:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:261:                                     GCCUACUAUUCAGUG15                                                             (2) INFORMATION FOR SEQ ID NO:262:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:262:                                     CUACUAUUCAGUGGC15                                                             (2) INFORMATION FOR SEQ ID NO:263:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:263:                                     UACUAUUCAGUGGCG15                                                             (2) INFORMATION FOR SEQ ID NO:264:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:264:                                     GAGAAAUAAAGGUUG15                                                             (2) INFORMATION FOR SEQ ID NO:265:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:265:                                     UAAAGGUUGCUUAGG15                                                             (2) INFORMATION FOR SEQ ID NO:266:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:266:                                     GGUUGCUUAGGAAAG15                                                             (2) INFORMATION FOR SEQ ID NO:267:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:267:                                     GUUGCUUAGGAAAGA15                                                             (2) INFORMATION FOR SEQ ID NO:268:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:268:                                     GGAAGAGCUGAUGAGGCCGAAAGGCCGAAACCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:269:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:269:                                     AGGAAGACUGAUGAGGCCGAAAGGCCGAAAACCUGC36                                        (2) INFORMATION FOR SEQ ID NO:270:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:270:                                     AGAGGAACUGAUGAGGCCGAAAGGCCGAAAGAACCU36                                        (2) INFORMATION FOR SEQ ID NO:271:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:271:                                     UGAGAGGCUGAUGAGGCCGAAAGGCCGAAAGAGAAC36                                        (2) INFORMATION FOR SEQ ID NO:272:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:272:                                     GUGAGAGCUGAUGAGGCCGAAAGGCCGAAAAGAGAA36                                        (2) INFORMATION FOR SEQ ID NO:273:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:273:                                     UAUGUGACUGAUGAGGCCGAAAGGCCGAAAGGAAGA36                                        (2) INFORMATION FOR SEQ ID NO:274:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:274:                                     AGUAUGUCUGAUGAGGCCGAAAGGCCGAAAGAGGAA36                                        (2) INFORMATION FOR SEQ ID NO:275:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:275:                                     GGGUCAGCUGAUGAGGCCGAAAGGCCGAAAUGUGAG36                                        (2) INFORMATION FOR SEQ ID NO:276:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:276:                                     GAGGGUGCUGAUGAGGCCGAAAGGCCGAAAGCCGUG36                                        (2) INFORMATION FOR SEQ ID NO:277:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:277:                                     GGGGAGACUGAUGAGGCCGAAAGGCCGAAAGGGUGG36                                        (2) INFORMATION FOR SEQ ID NO:278:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:278:                                     CAGGGGACUGAUGAGGCCGAAAGGCCGAAAGAGGGU36                                        (2) INFORMATION FOR SEQ ID NO:279:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:279:                                     UCCAGGGCUGAUGAGGCCGAAAGGCCGAAAGAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:280:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:280:                                     CGUCCCGCUGAUGAGGCCGAAAGGCCGAAAUCAUGC36                                        (2) INFORMATION FOR SEQ ID NO:281:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:281:                                     UCUUGGGCUGAUGAGGCCGAAAGGCCGAAAGCGCCU36                                        (2) INFORMATION FOR SEQ ID NO:282:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:282:                                     CCGCCUGCUGAUGAGGCCGAAAGGCCGAAAGCCCUG36                                        (2) INFORMATION FOR SEQ ID NO:283:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:283:                                     GAGGAACCUGAUGAGGCCGAAAGGCCGAAAGCACCG36                                        (2) INFORMATION FOR SEQ ID NO:284:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:284:                                     GCUGAGGCUGAUGAGGCCGAAAGGCCGAAACAAGCA36                                        (2) INFORMATION FOR SEQ ID NO:285:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:285:                                     GGCUGAGCUGAUGAGGCCGAAAGGCCGAAAACAAGC36                                        (2) INFORMATION FOR SEQ ID NO:286:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:286:                                     AGAGGCUCUGAUGAGGCCGAAAGGCCGAAAGGAACA36                                        (2) INFORMATION FOR SEQ ID NO:287:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:287:                                     AGGAGAACUGAUGAGGCCGAAAGGCCGAAAGGCUGA36                                        (2) INFORMATION FOR SEQ ID NO:288:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:288:                                     GAAGGAGCUGAUGAGGCCGAAAGGCCGAAAGAGGCU36                                        (2) INFORMATION FOR SEQ ID NO:289:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:289:                                     GGAAGGACUGAUGAGGCCGAAAGGCCGAAAAGAGGC36                                        (2) INFORMATION FOR SEQ ID NO:290:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:290:                                     CAGGAAGCUGAUGAGGCCGAAAGGCCGAAAGAAGAG36                                        (2) INFORMATION FOR SEQ ID NO:291:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:291:                                     GAUCAGGCUGAUGAGGCCGAAAGGCCGAAAGGAGAA36                                        (2) INFORMATION FOR SEQ ID NO:292:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:292:                                     CGAUCAGCUGAUGAGGCCGAAAGGCCGAAAAGGAGA36                                        (2) INFORMATION FOR SEQ ID NO:293:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:293:                                     CUGCCACCUGAUGAGGCCGAAAGGCCGAAAUCAGGA36                                        (2) INFORMATION FOR SEQ ID NO:294:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:294:                                     GGCAGAACUGAUGAGGCCGAAAGGCCGAAAGCGUGG36                                        (2) INFORMATION FOR SEQ ID NO:295:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:295:                                     CAGGCAGCUGAUGAGGCCGAAAGGCCGAAAGAGCGU36                                        (2) INFORMATION FOR SEQ ID NO:296:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:296:                                     GCAGGCACUGAUGAGGCCGAAAGGCCGAAAAGAGCG36                                        (2) INFORMATION FOR SEQ ID NO:297:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:297:                                     CACUCCACUGAUGAGGCCGAAAGGCCGAAAGUGCAG36                                        (2) INFORMATION FOR SEQ ID NO:298:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:298:                                     UCACUCCCUGAUGAGGCCGAAAGGCCGAAAAGUGCA36                                        (2) INFORMATION FOR SEQ ID NO:299:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:299:                                     GGGGGCCCUGAUGAGGCCGAAAGGCCGAAAUCACUC36                                        (2) INFORMATION FOR SEQ ID NO:300:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:300:                                     CCUGGGGCUGAUGAGGCCGAAAGGCCGAAACUCUUC36                                        (2) INFORMATION FOR SEQ ID NO:301:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:301:                                     UUAGAGACUGAUGAGGCCGAAAGGCCGAAAGGUCCC36                                        (2) INFORMATION FOR SEQ ID NO:302:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:302:                                     GAUUAGACUGAUGAGGCCGAAAGGCCGAAAGAGGUC36                                        (2) INFORMATION FOR SEQ ID NO:303:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:303:                                     CUGAUUACUGAUGAGGCCGAAAGGCCGAAAGAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:304:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:304:                                     GGCUGAUCUGAUGAGGCCGAAAGGCCGAAAGAGAGA36                                        (2) INFORMATION FOR SEQ ID NO:305:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:305:                                     GAGGGCUCUGAUGAGGCCGAAAGGCCGAAAUUAGAG36                                        (2) INFORMATION FOR SEQ ID NO:306:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:306:                                     UGGGCCACUGAUGAGGCCGAAAGGCCGAAAGGGCUG36                                        (2) INFORMATION FOR SEQ ID NO:307:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:307:                                     AGAAGAUCUGAUGAGGCCGAAAGGCCGAAAUCUGAC36                                        (2) INFORMATION FOR SEQ ID NO:308:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:308:                                     UCGAGAACUGAUGAGGCCGAAAGGCCGAAAUGAUCU36                                        (2) INFORMATION FOR SEQ ID NO:309:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:309:                                     GUUCGAGCUGAUGAGGCCGAAAGGCCGAAAGAUGAU36                                        (2) INFORMATION FOR SEQ ID NO:310:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:310:                                     GGUUCGACUGAUGAGGCCGAAAGGCCGAAAAGAUGA36                                        (2) INFORMATION FOR SEQ ID NO:311:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:311:                                     GGGGUUCCUGAUGAGGCCGAAAGGCCGAAAGAAGAU36                                        (2) INFORMATION FOR SEQ ID NO:312:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:312:                                     CAUGGGCCUGAUGAGGCCGAAAGGCCGAAACAGGCU36                                        (2) INFORMATION FOR SEQ ID NO:313:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:313:                                     UUGCUACCUGAUGAGGCCGAAAGGCCGAAACAUGGG36                                        (2) INFORMATION FOR SEQ ID NO:314:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:314:                                     GGUUUGCCUGAUGAGGCCGAAAGGCCGAAACAACAU36                                        (2) INFORMATION FOR SEQ ID NO:315:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:315:                                     UCAGCUUCUGAUGAGGCCGAAAGGCCGAAAGGGUUU36                                        (2) INFORMATION FOR SEQ ID NO:316:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:316:                                     GCCACUGCUGAUGAGGCCGAAAGGCCGAAAGCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:317:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:317:                                     UGGCCAGCUGAUGAGGCCGAAAGGCCGAAAGGGCAU36                                        (2) INFORMATION FOR SEQ ID NO:318:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:318:                                     AGCUGGUCUGAUGAGGCCGAAAGGCCGAAAUCUCUC36                                        (2) INFORMATION FOR SEQ ID NO:319:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:319:                                     GCCCUCUCUGAUGAGGCCGAAAGGCCGAAAUGGCAC36                                        (2) INFORMATION FOR SEQ ID NO:320:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:320:                                     GAUGAGGCUGAUGAGGCCGAAAGGCCGAAACAGGCC36                                        (2) INFORMATION FOR SEQ ID NO:321:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:321:                                     AGUAGAUCUGAUGAGGCCGAAAGGCCGAAAGGUACA36                                        (2) INFORMATION FOR SEQ ID NO:322:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:322:                                     GGGAGUACUGAUGAGGCCGAAAGGCCGAAAUGAGGU36                                        (2) INFORMATION FOR SEQ ID NO:323:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:323:                                     CUGGGAGCUGAUGAGGCCGAAAGGCCGAAAGAUGAG36                                        (2) INFORMATION FOR SEQ ID NO:324:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:324:                                     GACCUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGAU36                                        (2) INFORMATION FOR SEQ ID NO:325:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:325:                                     UGAAGAGCUGAUGAGGCCGAAAGGCCGAAACCUGGG36                                        (2) INFORMATION FOR SEQ ID NO:326:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:326:                                     CCUUGAACUGAUGAGGCCGAAAGGCCGAAAGGACCU36                                        (2) INFORMATION FOR SEQ ID NO:327:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:327:                                     GCCCUUGCUGAUGAGGCCGAAAGGCCGAAAGAGGAC36                                        (2) INFORMATION FOR SEQ ID NO:328:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:328:                                     GGCCCUUCUGAUGAGGCCGAAAGGCCGAAAAGAGGA36                                        (2) INFORMATION FOR SEQ ID NO:329:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:329:                                     AUGGGUGCUGAUGAGGCCGAAAGGCCGAAAGGGGCA36                                        (2) INFORMATION FOR SEQ ID NO:330:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:330:                                     GGGUGAGCUGAUGAGGCCGAAAGGCCGAAAGCACAU36                                        (2) INFORMATION FOR SEQ ID NO:331:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:331:                                     UGUGGGUCUGAUGAGGCCGAAAGGCCGAAAGGAGCA36                                        (2) INFORMATION FOR SEQ ID NO:332:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:332:                                     UGCGGCUCUGAUGAGGCCGAAAGGCCGAAAUGGUGU36                                        (2) INFORMATION FOR SEQ ID NO:333:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:333:                                     AGACGGCCUGAUGAGGCCGAAAGGCCGAAAUGCGGC36                                        (2) INFORMATION FOR SEQ ID NO:334:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:334:                                     GGUAGGACUGAUGAGGCCGAAAGGCCGAAACGGCGA36                                        (2) INFORMATION FOR SEQ ID NO:335:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:335:                                     CUGGUAGCUGAUGAGGCCGAAAGGCCGAAAGACGGC36                                        (2) INFORMATION FOR SEQ ID NO:336:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:336:                                     GGUCUGGCUGAUGAGGCCGAAAGGCCGAAAGGAGAC36                                        (2) INFORMATION FOR SEQ ID NO:337:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:337:                                     GGAGGUUCUGAUGAGGCCGAAAGGCCGAAACCUUGG36                                        (2) INFORMATION FOR SEQ ID NO:338:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:338:                                     CAGAGAGCUGAUGAGGCCGAAAGGCCGAAAGGUUGA36                                        (2) INFORMATION FOR SEQ ID NO:339:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:339:                                     UGGCAGACUGAUGAGGCCGAAAGGCCGAAAGGAGGU36                                        (2) INFORMATION FOR SEQ ID NO:340:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:340:                                     GAUGGCACUGAUGAGGCCGAAAGGCCGAAAGAGGAG36                                        (2) INFORMATION FOR SEQ ID NO:341:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:341:                                     GGCUCUUCUGAUGAGGCCGAAAGGCCGAAAUGGCAG36                                        (2) INFORMATION FOR SEQ ID NO:342:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:342:                                     GGGCUCACUGAUGAGGCCGAAAGGCCGAAACCAGGG36                                        (2) INFORMATION FOR SEQ ID NO:343:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:343:                                     CCAGAUACUGAUGAGGCCGAAAGGCCGAAAUGGGCU36                                        (2) INFORMATION FOR SEQ ID NO:344:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:344:                                     UCCCAGACUGAUGAGGCCGAAAGGCCGAAAGAUGGG36                                        (2) INFORMATION FOR SEQ ID NO:345:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:345:                                     CCUCCCACUGAUGAGGCCGAAAGGCCGAAAUAGAUG36                                        (2) INFORMATION FOR SEQ ID NO:346:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:346:                                     GCUGGAACUGAUGAGGCCGAAAGGCCGAAACCCCUC36                                        (2) INFORMATION FOR SEQ ID NO:347:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:347:                                     CAGCUGGCUGAUGAGGCCGAAAGGCCGAAAGACCCC36                                        (2) INFORMATION FOR SEQ ID NO:348:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:348:                                     CCAGCUGCUGAUGAGGCCGAAAGGCCGAAAAGACCC36                                        (2) INFORMATION FOR SEQ ID NO:349:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:349:                                     CAGCGCUCUGAUGAGGCCGAAAGGCCGAAAGUCGGU36                                        (2) INFORMATION FOR SEQ ID NO:350:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:350:                                     GCCGAUUCUGAUGAGGCCGAAAGGCCGAAAUCUCAG36                                        (2) INFORMATION FOR SEQ ID NO:351:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:351:                                     UCGGGCCCUGAUGAGGCCGAAAGGCCGAAAUUGAUC36                                        (2) INFORMATION FOR SEQ ID NO:352:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:352:                                     GUCGAGACUGAUGAGGCCGAAAGGCCGAAAGUCGGG36                                        (2) INFORMATION FOR SEQ ID NO:353:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:353:                                     AAGUCGACUGAUGAGGCCGAAAGGCCGAAAUAGUCG36                                        (2) INFORMATION FOR SEQ ID NO:354:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:354:                                     CAAAGUCCUGAUGAGGCCGAAAGGCCGAAAGAUAGU36                                        (2) INFORMATION FOR SEQ ID NO:355:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:355:                                     CUCGGCACUGAUGAGGCCGAAAGGCCGAAAGUCGAG36                                        (2) INFORMATION FOR SEQ ID NO:356:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:356:                                     ACUCGGCCUGAUGAGGCCGAAAGGCCGAAAAGUCGA36                                        (2) INFORMATION FOR SEQ ID NO:357:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:357:                                     CUGCCCACUGAUGAGGCCGAAAGGCCGAAACUCGGC36                                        (2) INFORMATION FOR SEQ ID NO:358:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:358:                                     CAAAGUACUGAUGAGGCCGAAAGGCCGAAACCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:359:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:359:                                     CCCAAAGCUGAUGAGGCCGAAAGGCCGAAAGACCUG36                                        (2) INFORMATION FOR SEQ ID NO:360:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:360:                                     GAUCCCACUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:361:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:361:                                     UGAUCCCCUGAUGAGGCCGAAAGGCCGAAAAGUAGA36                                        (2) INFORMATION FOR SEQ ID NO:362:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:362:                                     GGGCAAUCUGAUGAGGCCGAAAGGCCGAAAUCCCAA36                                        (2) INFORMATION FOR SEQ ID NO:363:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:363:                                     ACAGGGCCUGAUGAGGCCGAAAGGCCGAAAUGAUCC36                                        (2) INFORMATION FOR SEQ ID NO:364:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:364:                                     AAGGUUGCUGAUGAGGCCGAAAGGCCGAAAUGUUCG36                                        (2) INFORMATION FOR SEQ ID NO:365:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:365:                                     GUUUGGGCUGAUGAGGCCGAAAGGCCGAAAGGUUGG36                                        (2) INFORMATION FOR SEQ ID NO:366:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:366:                                     CGUUUGGCUGAUGAGGCCGAAAGGCCGAAAAGGUUG36                                        (2) INFORMATION FOR SEQ ID NO:367:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:367:                                     GGCAGGGCUGAUGAGGCCGAAAGGCCGAAAGGCGUU36                                        (2) INFORMATION FOR SEQ ID NO:368:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:368:                                     AUAAAGGCUGAUGAGGCCGAAAGGCCGAAAUUGGGG36                                        (2) INFORMATION FOR SEQ ID NO:369:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:369:                                     GGUAAUACUGAUGAGGCCGAAAGGCCGAAAGGGAUU36                                        (2) INFORMATION FOR SEQ ID NO:370:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:370:                                     GGGUAAUCUGAUGAGGCCGAAAGGCCGAAAAGGGAU36                                        (2) INFORMATION FOR SEQ ID NO:371:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:371:                                     GGGGUAACUGAUGAGGCCGAAAGGCCGAAAAAGGGA36                                        (2) INFORMATION FOR SEQ ID NO:372:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:372:                                     AGGGGGUCUGAUGAGGCCGAAAGGCCGAAAUAAAGG36                                        (2) INFORMATION FOR SEQ ID NO:373:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:373:                                     GAGGGGGCUGAUGAGGCCGAAAGGCCGAAAAUAAAG36                                        (2) INFORMATION FOR SEQ ID NO:374:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:374:                                     UCUGAAGCUGAUGAGGCCGAAAGGCCGAAAGGGGGU36                                        (2) INFORMATION FOR SEQ ID NO:375:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:375:                                     GUGUCUGCUGAUGAGGCCGAAAGGCCGAAAGGAGGG36                                        (2) INFORMATION FOR SEQ ID NO:376:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:376:                                     GGUGUCUCUGAUGAGGCCGAAAGGCCGAAAAGGAGG36                                        (2) INFORMATION FOR SEQ ID NO:377:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:377:                                     AGAGGUUCUGAUGAGGCCGAAAGGCCGAAAGGGUGU36                                        (2) INFORMATION FOR SEQ ID NO:378:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:378:                                     GCCAGAACUGAUGAGGCCGAAAGGCCGAAAGGUUGA36                                        (2) INFORMATION FOR SEQ ID NO:379:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:379:                                     GAGCCAGCUGAUGAGGCCGAAAGGCCGAAAGAGGUU36                                        (2) INFORMATION FOR SEQ ID NO:380:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:380:                                     UGAGCCACUGAUGAGGCCGAAAGGCCGAAAAGAGGU36                                        (2) INFORMATION FOR SEQ ID NO:381:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:381:                                     UCUUUUUCUGAUGAGGCCGAAAGGCCGAAAGCCAGA36                                        (2) INFORMATION FOR SEQ ID NO:382:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:382:                                     AGCCCCCCUGAUGAGGCCGAAAGGCCGAAAUUCUCU36                                        (2) INFORMATION FOR SEQ ID NO:383:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:383:                                     CGACCCUCUGAUGAGGCCGAAAGGCCGAAAGCCCCC36                                        (2) INFORMATION FOR SEQ ID NO:384:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:384:                                     CCGACCCCUGAUGAGGCCGAAAGGCCGAAAAGCCCC36                                        (2) INFORMATION FOR SEQ ID NO:385:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:385:                                     GGGUUCCCUGAUGAGGCCGAAAGGCCGAAACCCUAA36                                        (2) INFORMATION FOR SEQ ID NO:386:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:386:                                     AAGUUCUCUGAUGAGGCCGAAAGGCCGAAAGCUUGG36                                        (2) INFORMATION FOR SEQ ID NO:387:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:387:                                     AAAGUUCCUGAUGAGGCCGAAAGGCCGAAAAGCUUG36                                        (2) INFORMATION FOR SEQ ID NO:388:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:388:                                     UUGCUUACUGAUGAGGCCGAAAGGCCGAAAGUUCUA36                                        (2) INFORMATION FOR SEQ ID NO:389:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:389:                                     GUUGCUUCUGAUGAGGCCGAAAGGCCGAAAAGUUCU36                                        (2) INFORMATION FOR SEQ ID NO:390:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:390:                                     UGUUGCUCUGAUGAGGCCGAAAGGCCGAAAAAGUUC36                                        (2) INFORMATION FOR SEQ ID NO:391:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:391:                                     GGUUUCGCUGAUGAGGCCGAAAGGCCGAAAGUGGUG36                                        (2) INFORMATION FOR SEQ ID NO:392:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:392:                                     AGGUUUCCUGAUGAGGCCGAAAGGCCGAAAAGUGGU36                                        (2) INFORMATION FOR SEQ ID NO:393:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:393:                                     AUUCCUGCUGAUGAGGCCGAAAGGCCGAAAUCCCAG36                                        (2) INFORMATION FOR SEQ ID NO:394:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:394:                                     CAUUCCUCUGAUGAGGCCGAAAGGCCGAAAAUCCCA36                                        (2) INFORMATION FOR SEQ ID NO:395:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:395:                                     GAAUUCUCUGAUGAGGCCGAAAGGCCGAAAGUGGUU36                                        (2) INFORMATION FOR SEQ ID NO:396:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:396:                                     CAGUUUGCUGAUGAGGCCGAAAGGCCGAAAUUCUUA36                                        (2) INFORMATION FOR SEQ ID NO:397:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:397:                                     CCAGUUUCUGAUGAGGCCGAAAGGCCGAAAAUUCUU36                                        (2) INFORMATION FOR SEQ ID NO:398:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:398:                                     AGUUCUGCUGAUGAGGCCGAAAGGCCGAAAGGCCCC36                                        (2) INFORMATION FOR SEQ ID NO:399:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:399:                                     CCCCAGUCUGAUGAGGCCGAAAGGCCGAAAGUUCUG36                                        (2) INFORMATION FOR SEQ ID NO:400:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:400:                                     AAAGCUGCUGAUGAGGCCGAAAGGCCGAAAGGCCCC36                                        (2) INFORMATION FOR SEQ ID NO:401:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:401:                                     GGGAUCACUGAUGAGGCCGAAAGGCCGAAAGCUGUA36                                        (2) INFORMATION FOR SEQ ID NO:402:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:402:                                     AGGGAUCCUGAUGAGGCCGAAAGGCCGAAAAGCUGU36                                        (2) INFORMATION FOR SEQ ID NO:403:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:403:                                     UGUCAGGCUGAUGAGGCCGAAAGGCCGAAAUCAAAG36                                        (2) INFORMATION FOR SEQ ID NO:404:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:404:                                     GAUUCCACUGAUGAGGCCGAAAGGCCGAAAUGUCAG36                                        (2) INFORMATION FOR SEQ ID NO:405:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:405:                                     GUCUCCACUGAUGAGGCCGAAAGGCCGAAAUUCCAG36                                        (2) INFORMATION FOR SEQ ID NO:406:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:406:                                     AGAACCACUGAUGAGGCCGAAAGGCCGAAAGGCUCC36                                        (2) INFORMATION FOR SEQ ID NO:407:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:407:                                     CAGAACCCUGAUGAGGCCGAAAGGCCGAAAAGGCUC36                                        (2) INFORMATION FOR SEQ ID NO:408:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:408:                                     UGGCCAGCUGAUGAGGCCGAAAGGCCGAAACCAAAG36                                        (2) INFORMATION FOR SEQ ID NO:409:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:409:                                     CUGGCCACUGAUGAGGCCGAAAGGCCGAAAACCAAA36                                        (2) INFORMATION FOR SEQ ID NO:410:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:410:                                     UCUUCUCCUGAUGAGGCCGAAAGGCCGAAAGUCCUG36                                        (2) INFORMATION FOR SEQ ID NO:411:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:411:                                     UCUAGGUCUGAUGAGGCCGAAAGGCCGAAAGGUCUU36                                        (2) INFORMATION FOR SEQ ID NO:412:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:412:                                     CAAUUUCCUGAUGAGGCCGAAAGGCCGAAAGGUGAG36                                        (2) INFORMATION FOR SEQ ID NO:413:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:413:                                     UUGUGUCCUGAUGAGGCCGAAAGGCCGAAAUUUCUA36                                        (2) INFORMATION FOR SEQ ID NO:414:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:414:                                     AAGGCCUCUGAUGAGGCCGAAAGGCCGAAAGGUCCA36                                        (2) INFORMATION FOR SEQ ID NO:415:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:415:                                     GAAGGCCCUGAUGAGGCCGAAAGGCCGAAAAGGUCC36                                        (2) INFORMATION FOR SEQ ID NO:416:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:416:                                     AGAGAGGCUGAUGAGGCCGAAAGGCCGAAAGGCCUA36                                        (2) INFORMATION FOR SEQ ID NO:417:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:417:                                     GAGAGAGCUGAUGAGGCCGAAAGGCCGAAAAGGCCU36                                        (2) INFORMATION FOR SEQ ID NO:418:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:418:                                     CUGGAGACUGAUGAGGCCGAAAGGCCGAAAGGAAGG36                                        (2) INFORMATION FOR SEQ ID NO:419:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:419:                                     AUCUGGACUGAUGAGGCCGAAAGGCCGAAAGAGGAA36                                        (2) INFORMATION FOR SEQ ID NO:420:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:420:                                     ACAUCUGCUGAUGAGGCCGAAAGGCCGAAAGAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:421:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:421:                                     GUCUGGACUGAUGAGGCCGAAAGGCCGAAACAUCUG36                                        (2) INFORMATION FOR SEQ ID NO:422:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:422:                                     AGUCUGGCUGAUGAGGCCGAAAGGCCGAAAACAUCU36                                        (2) INFORMATION FOR SEQ ID NO:423:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:423:                                     AAGUCUGCUGAUGAGGCCGAAAGGCCGAAAAACAUC36                                        (2) INFORMATION FOR SEQ ID NO:424:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:424:                                     CUCAAGGCUGAUGAGGCCGAAAGGCCGAAAGUCUGG36                                        (2) INFORMATION FOR SEQ ID NO:425:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:425:                                     UCUCAAGCUGAUGAGGCCGAAAGGCCGAAAAGUCUG36                                        (2) INFORMATION FOR SEQ ID NO:426:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:426:                                     GUGUCUCCUGAUGAGGCCGAAAGGCCGAAAGGAAGU36                                        (2) INFORMATION FOR SEQ ID NO:427:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:427:                                     CCAUGGGCUGAUGAGGCCGAAAGGCCGAAAGGGCUG36                                        (2) INFORMATION FOR SEQ ID NO:428:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:428:                                     AUAGAGGCUGAUGAGGCCGAAAGGCCGAAAGCUGGC36                                        (2) INFORMATION FOR SEQ ID NO:429:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:429:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAGGGAGC36                                        (2) INFORMATION FOR SEQ ID NO:430:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:430:                                     ACAUAAACUGAUGAGGCCGAAAGGCCGAAAGAGGGA36                                        (2) INFORMATION FOR SEQ ID NO:431:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:431:                                     AAACAUACUGAUGAGGCCGAAAGGCCGAAAUAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:432:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:432:                                     CAAACAUCUGAUGAGGCCGAAAGGCCGAAAAUAGAG36                                        (2) INFORMATION FOR SEQ ID NO:433:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:433:                                     GCAAACACUGAUGAGGCCGAAAGGCCGAAAAAUAGA36                                        (2) INFORMATION FOR SEQ ID NO:434:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:434:                                     AAGUGCACUGAUGAGGCCGAAAGGCCGAAACAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:435:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:435:                                     CAAGUGCCUGAUGAGGCCGAAAGGCCGAAAACAUAA36                                        (2) INFORMATION FOR SEQ ID NO:436:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:436:                                     UAAUCACCUGAUGAGGCCGAAAGGCCGAAAGUGCAA36                                        (2) INFORMATION FOR SEQ ID NO:437:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:437:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUCACAA36                                        (2) INFORMATION FOR SEQ ID NO:438:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:438:                                     UAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUCACA36                                        (2) INFORMATION FOR SEQ ID NO:439:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:439:                                     AAUAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUCA36                                        (2) INFORMATION FOR SEQ ID NO:440:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:440:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUC36                                        (2) INFORMATION FOR SEQ ID NO:441:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:441:                                     UAAAUAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:442:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:442:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:443:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:443:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:444:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:444:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:445:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:445:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:446:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:446:                                     UAAUAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:447:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:447:                                     AAUAAUACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:448:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:448:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:449:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:449:                                     UAAAUAACUGAUGAGGCCGAAAGGCCGAAAAAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:450:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:450:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:451:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:451:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:452:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:452:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:453:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:453:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:454:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:454:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:455:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:455:                                     GUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:456:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:456:                                     UGUAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:457:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:457:                                     CUGUAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:458:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:458:                                     AUCUGUACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:459:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:459:                                     CAUCUGUCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:460:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:460:                                     UCAUCUGCUGAUGAGGCCGAAAGGCCGAAAAAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:461:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:461:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAACAUUCA36                                        (2) INFORMATION FOR SEQ ID NO:462:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:462:                                     CCAAAUACUGAUGAGGCCGAAAGGCCGAAAUACAUU36                                        (2) INFORMATION FOR SEQ ID NO:463:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:463:                                     CCCAAAUCUGAUGAGGCCGAAAGGCCGAAAAUACAU36                                        (2) INFORMATION FOR SEQ ID NO:464:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:464:                                     UCCCAAACUGAUGAGGCCGAAAGGCCGAAAAAUACA36                                        (2) INFORMATION FOR SEQ ID NO:465:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:465:                                     UCUCCCACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:466:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:466:                                     GUCUCCCCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:467:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:467:                                     CCCAGGACUGAUGAGGCCGAAAGGCCGAAACCCCGG36                                        (2) INFORMATION FOR SEQ ID NO:468:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:468:                                     CCCCCAGCUGAUGAGGCCGAAAGGCCGAAAUACCCC36                                        (2) INFORMATION FOR SEQ ID NO:469:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:469:                                     CAGCUCCCUGAUGAGGCCGAAAGGCCGAAACAUUGG36                                        (2) INFORMATION FOR SEQ ID NO:470:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:470:                                     CUGAGCCCUGAUGAGGCCGAAAGGCCGAAAGGCAGC36                                        (2) INFORMATION FOR SEQ ID NO:471:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:471:                                     CAUGUCUCUGAUGAGGCCGAAAGGCCGAAAGCCAAG36                                        (2) INFORMATION FOR SEQ ID NO:472:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:472:                                     CACGGAACUGAUGAGGCCGAAAGGCCGAAACAUGUC36                                        (2) INFORMATION FOR SEQ ID NO:473:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:473:                                     UCACGGACUGAUGAGGCCGAAAGGCCGAAAACAUGU36                                        (2) INFORMATION FOR SEQ ID NO:474:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:474:                                     UUCACGGCUGAUGAGGCCGAAAGGCCGAAAAACAUG36                                        (2) INFORMATION FOR SEQ ID NO:475:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:475:                                     UUUCACGCUGAUGAGGCCGAAAGGCCGAAAAAACAU36                                        (2) INFORMATION FOR SEQ ID NO:476:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:476:                                     AACAGCCCUGAUGAGGCCGAAAGGCCGAAAUUGUUC36                                        (2) INFORMATION FOR SEQ ID NO:477:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:477:                                     ACAUGGGCUGAUGAGGCCGAAAGGCCGAAACAGCCU36                                        (2) INFORMATION FOR SEQ ID NO:478:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:478:                                     UACAUGGCUGAUGAGGCCGAAAGGCCGAAAACAGCC36                                        (2) INFORMATION FOR SEQ ID NO:479:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:479:                                     AGGGGGCCUGAUGAGGCCGAAAGGCCGAAACAUGGG36                                        (2) INFORMATION FOR SEQ ID NO:480:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:480:                                     AGGCACACUGAUGAGGCCGAAAGGCCGAAAGGCCAG36                                        (2) INFORMATION FOR SEQ ID NO:481:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:481:                                     UCAAAAGCUGAUGAGGCCGAAAGGCCGAAAGGCACA36                                        (2) INFORMATION FOR SEQ ID NO:482:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:482:                                     AUCAAAACUGAUGAGGCCGAAAGGCCGAAAAGGCAC36                                        (2) INFORMATION FOR SEQ ID NO:483:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:483:                                     UAAUCAACUGAUGAGGCCGAAAGGCCGAAAGAAGGC36                                        (2) INFORMATION FOR SEQ ID NO:484:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:484:                                     AUAAUCACUGAUGAGGCCGAAAGGCCGAAAAGAAGG36                                        (2) INFORMATION FOR SEQ ID NO:485:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:485:                                     CAUAAUCCUGAUGAGGCCGAAAGGCCGAAAAAGAAG36                                        (2) INFORMATION FOR SEQ ID NO:486:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:486:                                     AAAACAUCUGAUGAGGCCGAAAGGCCGAAAUCAAAA36                                        (2) INFORMATION FOR SEQ ID NO:487:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:487:                                     AAAAACACUGAUGAGGCCGAAAGGCCGAAAAUCAAA36                                        (2) INFORMATION FOR SEQ ID NO:488:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:488:                                     UUUAAAACUGAUGAGGCCGAAAGGCCGAAACAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:489:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:489:                                     UUUUAAACUGAUGAGGCCGAAAGGCCGAAAACAUAA36                                        (2) INFORMATION FOR SEQ ID NO:490:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:490:                                     AUUUUAACUGAUGAGGCCGAAAGGCCGAAAAACAUA36                                        (2) INFORMATION FOR SEQ ID NO:491:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:491:                                     UAUUUUACUGAUGAGGCCGAAAGGCCGAAAAAACAU36                                        (2) INFORMATION FOR SEQ ID NO:492:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:492:                                     AUAUUUUCUGAUGAGGCCGAAAGGCCGAAAAAAACA36                                        (2) INFORMATION FOR SEQ ID NO:493:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:493:                                     AAUAUUUCUGAUGAGGCCGAAAGGCCGAAAAAAAAC36                                        (2) INFORMATION FOR SEQ ID NO:494:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:494:                                     CAGAUAACUGAUGAGGCCGAAAGGCCGAAAUUUUAA36                                        (2) INFORMATION FOR SEQ ID NO:495:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:495:                                     AUCAGAUCUGAUGAGGCCGAAAGGCCGAAAUAUUUU36                                        (2) INFORMATION FOR SEQ ID NO:496:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:496:                                     AAUCAGACUGAUGAGGCCGAAAGGCCGAAAAUAUUU36                                        (2) INFORMATION FOR SEQ ID NO:497:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:497:                                     UUAAUCACUGAUGAGGCCGAAAGGCCGAAAUAAUAU36                                        (2) INFORMATION FOR SEQ ID NO:498:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:498:                                     ACAACUUCUGAUGAGGCCGAAAGGCCGAAAUCAGAU36                                        (2) INFORMATION FOR SEQ ID NO:499:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:499:                                     GACAACUCUGAUGAGGCCGAAAGGCCGAAAAUCAGA36                                        (2) INFORMATION FOR SEQ ID NO:500:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:500:                                     UUUAGACCUGAUGAGGCCGAAAGGCCGAAACUUAAU36                                        (2) INFORMATION FOR SEQ ID NO:501:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:501:                                     UUGUUUACUGAUGAGGCCGAAAGGCCGAAACAACUU36                                        (2) INFORMATION FOR SEQ ID NO:502:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:502:                                     CAUUGUUCUGAUGAGGCCGAAAGGCCGAAAGACAAC36                                        (2) INFORMATION FOR SEQ ID NO:503:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:503:                                     GUCACCACUGAUGAGGCCGAAAGGCCGAAAUCAGCA36                                        (2) INFORMATION FOR SEQ ID NO:504:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:504:                                     GGUCACCCUGAUGAGGCCGAAAGGCCGAAAAUCAGC36                                        (2) INFORMATION FOR SEQ ID NO:505:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:505:                                     AAUGAGUCUGAUGAGGCCGAAAGGCCGAAACAGUUG36                                        (2) INFORMATION FOR SEQ ID NO:506:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:506:                                     CAGCAAUCUGAUGAGGCCGAAAGGCCGAAAGUGACA36                                        (2) INFORMATION FOR SEQ ID NO:507:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:507:                                     CCUCAGCCUGAUGAGGCCGAAAGGCCGAAAUGAGUG36                                        (2) INFORMATION FOR SEQ ID NO:508:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:508:                                     GGGAGCACUGAUGAGGCCGAAAGGCCGAAAGGCCUC36                                        (2) INFORMATION FOR SEQ ID NO:509:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:509:                                     CCCUGGGCUGAUGAGGCCGAAAGGCCGAAAGCAGAG36                                        (2) INFORMATION FOR SEQ ID NO:510:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:510:                                     CAGACACCUGAUGAGGCCGAAAGGCCGAAACUCCCU36                                        (2) INFORMATION FOR SEQ ID NO:511:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:511:                                     GAUUACACUGAUGAGGCCGAAAGGCCGAAACACAAC36                                        (2) INFORMATION FOR SEQ ID NO:512:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:512:                                     GGCCGAUCUGAUGAGGCCGAAAGGCCGAAACAGACA36                                        (2) INFORMATION FOR SEQ ID NO:513:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:513:                                     GUAGGCCCUGAUGAGGCCGAAAGGCCGAAAUUACAG36                                        (2) INFORMATION FOR SEQ ID NO:514:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:514:                                     UGAAUAGCUGAUGAGGCCGAAAGGCCGAAAGGCCGA36                                        (2) INFORMATION FOR SEQ ID NO:515:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:515:                                     CACUGAACUGAUGAGGCCGAAAGGCCGAAAGUAGGC36                                        (2) INFORMATION FOR SEQ ID NO:516:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:516:                                     GCCACUGCUGAUGAGGCCGAAAGGCCGAAAUAGUAG36                                        (2) INFORMATION FOR SEQ ID NO:517:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:517:                                     CGCCACUCUGAUGAGGCCGAAAGGCCGAAAAUAGUA36                                        (2) INFORMATION FOR SEQ ID NO:518:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:518:                                     CAACCUUCUGAUGAGGCCGAAAGGCCGAAAUUUCUC36                                        (2) INFORMATION FOR SEQ ID NO:519:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:519:                                     CCUAAGCCUGAUGAGGCCGAAAGGCCGAAACCUUUA36                                        (2) INFORMATION FOR SEQ ID NO:520:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:520:                                     CUUUCCUCUGAUGAGGCCGAAAGGCCGAAAGCAACC36                                        (2) INFORMATION FOR SEQ ID NO:521:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:521:                                     UCUUUCCCUGAUGAGGCCGAAAGGCCGAAAAGCAAC36                                        (2) INFORMATION FOR SEQ ID NO:522:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:522:                                     UGGAAAUAGCUCCCA15                                                             (2) INFORMATION FOR SEQ ID NO:523:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:523:                                     GGCAGGUUCUGUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:524:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:524:                                     GGCAGGUUCUGUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:525:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:525:                                     GCAGGUUCUGUCCCU15                                                             (2) INFORMATION FOR SEQ ID NO:526:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:526:                                     GCAGGUUCUGUCCCU15                                                             (2) INFORMATION FOR SEQ ID NO:527:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:527:                                     GUUCUGUCCCUUUCA15                                                             (2) INFORMATION FOR SEQ ID NO:528:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:528:                                     UGUCCCUUUCACUCA15                                                             (2) INFORMATION FOR SEQ ID NO:529:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:529:                                     GUCCCUUUCACUCAC15                                                             (2) INFORMATION FOR SEQ ID NO:530:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:530:                                     GUCCCUUUCACUCAC15                                                             (2) INFORMATION FOR SEQ ID NO:531:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:531:                                     UCCCUUUCACUCACU15                                                             (2) INFORMATION FOR SEQ ID NO:532:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:532:                                     UUUCACUCACUGGCC15                                                             (2) INFORMATION FOR SEQ ID NO:533:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:533:                                     GCCACAUCUCCCUCC15                                                             (2) INFORMATION FOR SEQ ID NO:534:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:534:                                     CACAUCUCCCUCCAG15                                                             (2) INFORMATION FOR SEQ ID NO:535:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:535:                                     GCAUGAUCCGCGACG15                                                             (2) INFORMATION FOR SEQ ID NO:536:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:536:                                     AGGCACUCCCCCAAA15                                                             (2) INFORMATION FOR SEQ ID NO:537:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:537:                                     GGGGCUUCCAGAACU15                                                             (2) INFORMATION FOR SEQ ID NO:538:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:538:                                     GGGGCUUCCAGAACU15                                                             (2) INFORMATION FOR SEQ ID NO:539:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:539:                                     CAGAACUCCAGGCGG15                                                             (2) INFORMATION FOR SEQ ID NO:540:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:540:                                     CAGAACUCCAGGCGG15                                                             (2) INFORMATION FOR SEQ ID NO:541:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:541:                                     GGUGCCUAUGUCUCA15                                                             (2) INFORMATION FOR SEQ ID NO:542:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:542:                                     GGUGCCUAUGUCUCA15                                                             (2) INFORMATION FOR SEQ ID NO:543:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:543:                                     UCAGCCUCUUCUCAU15                                                             (2) INFORMATION FOR SEQ ID NO:544:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:544:                                     UCAGCCUCUUCUCAU15                                                             (2) INFORMATION FOR SEQ ID NO:545:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:545:                                     AGCCUCUUCUCAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:546:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:546:                                     AGCCUCUUCUCAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:547:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:547:                                     GCCUCUUCUCAUUCC15                                                             (2) INFORMATION FOR SEQ ID NO:548:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:548:                                     GCCUCUUCUCAUUCC15                                                             (2) INFORMATION FOR SEQ ID NO:549:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:549:                                     CUCUUCUCAUUCCUG15                                                             (2) INFORMATION FOR SEQ ID NO:550:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:550:                                     UUCUCAUUCCUGCUU15                                                             (2) INFORMATION FOR SEQ ID NO:551:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:551:                                     UCUCAUUCCUGCUUG15                                                             (2) INFORMATION FOR SEQ ID NO:552:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:552:                                     UCCUGCUUGUGGCAG15                                                             (2) INFORMATION FOR SEQ ID NO:553:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:553:                                     CCACGCUCUUCUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:554:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:554:                                     ACGCUCUUCUGUCUA15                                                             (2) INFORMATION FOR SEQ ID NO:555:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:555:                                     CGCUCUUCUGUCUAC15                                                             (2) INFORMATION FOR SEQ ID NO:556:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:556:                                     CUUCUGUCUACUGAA15                                                             (2) INFORMATION FOR SEQ ID NO:557:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:557:                                     UCUGUCUACUGAACU15                                                             (2) INFORMATION FOR SEQ ID NO:558:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:558:                                     CUGAACUUCGGGGUG15                                                             (2) INFORMATION FOR SEQ ID NO:559:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:559:                                     UGAACUUCGGGGUGA15                                                             (2) INFORMATION FOR SEQ ID NO:560:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:560:                                     UGAACUUCGGGGUGA15                                                             (2) INFORMATION FOR SEQ ID NO:561:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:561:                                     GGGUGAUCGGUCCCC15                                                             (2) INFORMATION FOR SEQ ID NO:562:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:562:                                     GGGUGAUCGGUCCCC15                                                             (2) INFORMATION FOR SEQ ID NO:563:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:563:                                     GAGAAGUUCCCAAAU15                                                             (2) INFORMATION FOR SEQ ID NO:564:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:564:                                     CCUCCCUCUCAUCAG15                                                             (2) INFORMATION FOR SEQ ID NO:565:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:565:                                     UCCCUCUCAUCAGUU15                                                             (2) INFORMATION FOR SEQ ID NO:566:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:566:                                     UCCCUCUCAUCAGUU15                                                             (2) INFORMATION FOR SEQ ID NO:567:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:567:                                     CUCUCAUCAGUUCUA15                                                             (2) INFORMATION FOR SEQ ID NO:568:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:568:                                     CAGUUCUAUGGCCCA15                                                             (2) INFORMATION FOR SEQ ID NO:569:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:569:                                     AGACCCUCACACUCA15                                                             (2) INFORMATION FOR SEQ ID NO:570:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:570:                                     UCACACUCAGAUCAU15                                                             (2) INFORMATION FOR SEQ ID NO:571:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:571:                                     CUCAGAUCAUCUUCU15                                                             (2) INFORMATION FOR SEQ ID NO:572:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:572:                                     AGAUCAUCUUCUCAA15                                                             (2) INFORMATION FOR SEQ ID NO:573:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:573:                                     AUCAUCUUCUCAAAA15                                                             (2) INFORMATION FOR SEQ ID NO:574:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:574:                                     AUCAUCUUCUCAAAA15                                                             (2) INFORMATION FOR SEQ ID NO:575:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:575:                                     UCAUCUUCUCAAAAU15                                                             (2) INFORMATION FOR SEQ ID NO:576:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:576:                                     AUCUUCUCAAAAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:577:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:577:                                     AUCUUCUCAAAAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:578:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:578:                                     AUCUUCUCAAAAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:579:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:579:                                     AGCCUGUAGCCCACG15                                                             (2) INFORMATION FOR SEQ ID NO:580:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:580:                                     ACGUCGUAGCAAACC15                                                             (2) INFORMATION FOR SEQ ID NO:581:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:581:                                     ACGCCCUCCUGGCCA15                                                             (2) INFORMATION FOR SEQ ID NO:582:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:582:                                     GGGUUGUACCUUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:583:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:583:                                     GGGUUGUACCUUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:584:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:584:                                     UGUACCUUGUCUACU15                                                             (2) INFORMATION FOR SEQ ID NO:585:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:585:                                     ACCUUGUCUACUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:586:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:586:                                     CUUGUCUACUCCCAG15                                                             (2) INFORMATION FOR SEQ ID NO:587:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:587:                                     GUCUACUCCCAGGUU15                                                             (2) INFORMATION FOR SEQ ID NO:588:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:588:                                     GUCUACUCCCAGGUU15                                                             (2) INFORMATION FOR SEQ ID NO:589:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:589:                                     GUCUACUCCCAGGUU15                                                             (2) INFORMATION FOR SEQ ID NO:590:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:590:                                     CCCAGGUUCUCUUCA15                                                             (2) INFORMATION FOR SEQ ID NO:591:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:591:                                     CCAGGUUCUCUUCAA15                                                             (2) INFORMATION FOR SEQ ID NO:592:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:592:                                     CCAGGUUCUCUUCAA15                                                             (2) INFORMATION FOR SEQ ID NO:593:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:593:                                     AGGUUCUCUUCAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:594:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:594:                                     AGGUUCUCUUCAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:595:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:595:                                     GUUCUCUUCAAGGGA15                                                             (2) INFORMATION FOR SEQ ID NO:596:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:596:                                     UUCUCUUCAAGGGAC15                                                             (2) INFORMATION FOR SEQ ID NO:597:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:597:                                     CCCGACUACGUGCUC15                                                             (2) INFORMATION FOR SEQ ID NO:598:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:598:                                     ACGUGCUCCUCACCC15                                                             (2) INFORMATION FOR SEQ ID NO:599:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:599:                                     ACGUGCUCCUCACCC15                                                             (2) INFORMATION FOR SEQ ID NO:600:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:600:                                     UGCUCCUCACCCACA15                                                             (2) INFORMATION FOR SEQ ID NO:601:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:601:                                     ACACCGUCAGCCGAU15                                                             (2) INFORMATION FOR SEQ ID NO:602:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:602:                                     ACACCGUCAGCCGAU15                                                             (2) INFORMATION FOR SEQ ID NO:603:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:603:                                     AGCCGAUUUGCUAUC15                                                             (2) INFORMATION FOR SEQ ID NO:604:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:604:                                     AUUUGCUAUCUCAUA15                                                             (2) INFORMATION FOR SEQ ID NO:605:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:605:                                     UUGCUAUCUCAUACC15                                                             (2) INFORMATION FOR SEQ ID NO:606:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:606:                                     GCUAUCUCAUACCAG15                                                             (2) INFORMATION FOR SEQ ID NO:607:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:607:                                     AGAAAGUCAACCUCC15                                                             (2) INFORMATION FOR SEQ ID NO:608:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:608:                                     UCAACCUCCUCUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:609:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:609:                                     UCAACCUCCUCUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:610:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:610:                                     ACCUCCUCUCUGCCG15                                                             (2) INFORMATION FOR SEQ ID NO:611:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:611:                                     CUCCUCUCUGCCGUC15                                                             (2) INFORMATION FOR SEQ ID NO:612:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:612:                                     CUGCCGUCAAGAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:613:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:613:                                     CUGCCGUCAAGAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:614:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:614:                                     CUGCCGUCAAGAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:615:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:615:                                     CCCUGGUAUGAGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:616:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:616:                                     CCCUGGUAUGAGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:617:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:617:                                     AGCCCAUAUACCUGG15                                                             (2) INFORMATION FOR SEQ ID NO:618:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:618:                                     CCCAUAUACCUGGGA15                                                             (2) INFORMATION FOR SEQ ID NO:619:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:619:                                     GAGGAGUCUUCCAGC15                                                             (2) INFORMATION FOR SEQ ID NO:620:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:620:                                     GAGGAGUCUUCCAGC15                                                             (2) INFORMATION FOR SEQ ID NO:621:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:621:                                     GGAGUCUUCCAGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:622:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:622:                                     GAGUCUUCCAGCUGG15                                                             (2) INFORMATION FOR SEQ ID NO:623:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:623:                                     ACCAACUCAGCGCUG15                                                             (2) INFORMATION FOR SEQ ID NO:624:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:624:                                     CUGAGGUCAAUCUGC15                                                             (2) INFORMATION FOR SEQ ID NO:625:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:625:                                     GGUCAAUCUGCCCAA15                                                             (2) INFORMATION FOR SEQ ID NO:626:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:626:                                     CCCAAGUACUUAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:627:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:627:                                     AGUACUUAGACUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:628:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:628:                                     UUAGACUUUGCGGAG15                                                             (2) INFORMATION FOR SEQ ID NO:629:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:629:                                     UAGACUUUGCGGAGU15                                                             (2) INFORMATION FOR SEQ ID NO:630:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:630:                                     GCGGAGUCCGGGCAG15                                                             (2) INFORMATION FOR SEQ ID NO:631:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:631:                                     GGCAGGUCUACUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:632:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:632:                                     CAGGUCUACUUUGGA15                                                             (2) INFORMATION FOR SEQ ID NO:633:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:633:                                     CAGGUCUACUUUGGA15                                                             (2) INFORMATION FOR SEQ ID NO:634:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:634:                                     CAGGUCUACUUUGGA15                                                             (2) INFORMATION FOR SEQ ID NO:635:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:635:                                     GUCUACUUUGGAGUC15                                                             (2) INFORMATION FOR SEQ ID NO:636:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:636:                                     UCUACUUUGGAGUCA15                                                             (2) INFORMATION FOR SEQ ID NO:637:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:637:                                     UUGGAGUCAUUGCUC15                                                             (2) INFORMATION FOR SEQ ID NO:638:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:638:                                     GAGUCAUUGCUCUGU15                                                             (2) INFORMATION FOR SEQ ID NO:639:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:639:                                     AUCCAUUCUCUACCC15                                                             (2) INFORMATION FOR SEQ ID NO:640:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:640:                                     AUUCUCUACCCAGCC15                                                             (2) INFORMATION FOR SEQ ID NO:641:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:641:                                     CCCCACUCUGACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:642:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:642:                                     CCCCACUCUGACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:643:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:643:                                     CCCCACUCUGACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:644:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:644:                                     GACCCCUUUACUCUG15                                                             (2) INFORMATION FOR SEQ ID NO:645:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:645:                                     ACCCCUUUACUCUGA15                                                             (2) INFORMATION FOR SEQ ID NO:646:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:646:                                     CUUUACUCUGACCCC15                                                             (2) INFORMATION FOR SEQ ID NO:647:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:647:                                     GACCCCUUUAUUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:648:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:648:                                     GACCCCUUUAUUGUC15                                                             (2) INFORMATION FOR SEQ ID NO:649:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:649:                                     CCUUUAUUGUCUACU15                                                             (2) INFORMATION FOR SEQ ID NO:650:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:650:                                     GUCUACUCCUCAGAG15                                                             (2) INFORMATION FOR SEQ ID NO:651:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:651:                                     UACUCCUCAGAGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:652:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:652:                                     UCUAACUUAGAAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:653:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:653:                                     UCUAACUUAGAAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:654:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:654:                                     CUAACUUAGAAAGGG15                                                             (2) INFORMATION FOR SEQ ID NO:655:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:655:                                     AGGGGAUUAUGGCUC15                                                             (2) INFORMATION FOR SEQ ID NO:656:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:656:                                     AGGGGAUUAUGGCUC15                                                             (2) INFORMATION FOR SEQ ID NO:657:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:657:                                     GGGGAUUAUGGCUCA15                                                             (2) INFORMATION FOR SEQ ID NO:658:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:658:                                     UCAGAGUCCAACUCU15                                                             (2) INFORMATION FOR SEQ ID NO:659:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:659:                                     CUGUGCUCAGAGCUU15                                                             (2) INFORMATION FOR SEQ ID NO:660:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:660:                                     CAGAGCUUUCAACAA15                                                             (2) INFORMATION FOR SEQ ID NO:661:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:661:                                     AGAGCUUUCAACAAC15                                                             (2) INFORMATION FOR SEQ ID NO:662:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:662:                                     GAGCUUUCAACAACU15                                                             (2) INFORMATION FOR SEQ ID NO:663:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:663:                                     UGGGCCUCUCAUGCA15                                                             (2) INFORMATION FOR SEQ ID NO:664:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:664:                                     AAGGACUCAAAUGGG15                                                             (2) INFORMATION FOR SEQ ID NO:665:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:665:                                     AUGGGCUUUCCGAAU15                                                             (2) INFORMATION FOR SEQ ID NO:666:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:666:                                     UGGGCUUUCCGAAUU15                                                             (2) INFORMATION FOR SEQ ID NO:667:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:667:                                     GGGCUUUCCGAAUUC15                                                             (2) INFORMATION FOR SEQ ID NO:668:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:668:                                     CCGAAUUCACUGGAG15                                                             (2) INFORMATION FOR SEQ ID NO:669:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:669:                                     CGAAUGUCCAUUCCU15                                                             (2) INFORMATION FOR SEQ ID NO:670:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:670:                                     GAGUGGUCAGGUUGC15                                                             (2) INFORMATION FOR SEQ ID NO:671:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:671:                                     UCUGUCUCAGAAUGA15                                                             (2) INFORMATION FOR SEQ ID NO:672:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:672:                                     AAGAUCUCAGGCCUU15                                                             (2) INFORMATION FOR SEQ ID NO:673:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:673:                                     CAGGCCUUCCUACCU15                                                             (2) INFORMATION FOR SEQ ID NO:674:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:674:                                     AGGCCUUCCUACCUU15                                                             (2) INFORMATION FOR SEQ ID NO:675:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:675:                                     CCUUCCUACCUUCAG15                                                             (2) INFORMATION FOR SEQ ID NO:676:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:676:                                     CCUACCUUCAGACCU15                                                             (2) INFORMATION FOR SEQ ID NO:677:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:677:                                     CCUACCUUCAGACCU15                                                             (2) INFORMATION FOR SEQ ID NO:678:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:678:                                     CCUACCUUCAGACCU15                                                             (2) INFORMATION FOR SEQ ID NO:679:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:679:                                     CCUACCUUCAGACCU15                                                             (2) INFORMATION FOR SEQ ID NO:680:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:680:                                     CUACCUUCAGACCUU15                                                             (2) INFORMATION FOR SEQ ID NO:681:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:681:                                     CUACCUUCAGACCUU15                                                             (2) INFORMATION FOR SEQ ID NO:682:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:682:                                     CAGACCUUUCCAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:683:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:683:                                     CAGACCUUUCCAGAC15                                                             (2) INFORMATION FOR SEQ ID NO:684:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:684:                                     AGACCUUUCCAGACU15                                                             (2) INFORMATION FOR SEQ ID NO:685:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:685:                                     AGACCUUUCCAGACU15                                                             (2) INFORMATION FOR SEQ ID NO:686:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:686:                                     GACCUUUCCAGACUC15                                                             (2) INFORMATION FOR SEQ ID NO:687:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:687:                                     GACUCUUCCCUGAGG15                                                             (2) INFORMATION FOR SEQ ID NO:688:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:688:                                     CAGCCUUCCUCACAG15                                                             (2) INFORMATION FOR SEQ ID NO:689:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:689:                                     CCCCCCUCUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:690:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:690:                                     CCCCCCUCUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:691:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:691:                                     CCCCUCUAUUUAUAU15                                                             (2) INFORMATION FOR SEQ ID NO:692:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:692:                                     CCUCUAUUUAUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:693:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:693:                                     CCUCUAUUUAUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:694:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:694:                                     CUCUAUUUAUAUUUG15                                                             (2) INFORMATION FOR SEQ ID NO:695:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:695:                                     UCUAUUUAUAUUUGC15                                                             (2) INFORMATION FOR SEQ ID NO:696:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:696:                                     UUUAUAUUUGCACUU15                                                             (2) INFORMATION FOR SEQ ID NO:697:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:697:                                     UUUAUAUUUGCACUU15                                                             (2) INFORMATION FOR SEQ ID NO:698:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:698:                                     UUAUAUUUGCACUUA15                                                             (2) INFORMATION FOR SEQ ID NO:699:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:699:                                     UUGCACUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:700:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:700:                                     CACUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:701:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:701:                                     ACUUAUUAUUUAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:702:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:702:                                     UUAUUAUUUAUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:703:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:703:                                     UAUUAUUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:704:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:704:                                     UAUUAUUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:705:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:705:                                     AUUAUUUAUUAUUUA15                                                             (2) INFORMATION FOR SEQ ID NO:706:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:706:                                     UAUUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:707:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:707:                                     UAUUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:708:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:708:                                     UAUUUAUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:709:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:709:                                     AUUUAUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:710:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:710:                                     AUUUAUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:711:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:711:                                     AUUUAUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:712:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:712:                                     UUAUUAUUUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:713:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:713:                                     UUAUUAUUUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:714:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:714:                                     UUAUUAUUUAUUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:715:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:715:                                     UAUUAUUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:716:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:716:                                     UAUUAUUUAUUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:717:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:717:                                     AUUAUUUAUUUAUUA15                                                             (2) INFORMATION FOR SEQ ID NO:718:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:718:                                     UAUUUAUUUAUUAUU15                                                             (2) INFORMATION FOR SEQ ID NO:719:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:719:                                     AUUUAUUUAUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:720:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:720:                                     UUUAUUUAUUAUUUA15                                                             (2) INFORMATION FOR SEQ ID NO:721:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:721:                                     AUUAUUUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:722:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:722:                                     UAUUUAUUUAUUUGC15                                                             (2) INFORMATION FOR SEQ ID NO:723:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:723:                                     AUUUAUUUAUUUGCU15                                                             (2) INFORMATION FOR SEQ ID NO:724:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:724:                                     UUUAUUUAUUUGCUU15                                                             (2) INFORMATION FOR SEQ ID NO:725:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:725:                                     UAUUUAUUUGCUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:726:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:726:                                     AUUUAUUUGCUUAUG15                                                             (2) INFORMATION FOR SEQ ID NO:727:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:727:                                     AUUUGCUUAUGAAUG15                                                             (2) INFORMATION FOR SEQ ID NO:728:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:728:                                     UUUGCUUAUGAAUGU15                                                             (2) INFORMATION FOR SEQ ID NO:729:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:729:                                     UGAAUGUAUUUAUUU15                                                             (2) INFORMATION FOR SEQ ID NO:730:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:730:                                     AAUGUAUUUAUUUGG15                                                             (2) INFORMATION FOR SEQ ID NO:731:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:731:                                     AUGUAUUUAUUUGGA15                                                             (2) INFORMATION FOR SEQ ID NO:732:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:732:                                     UGUAUUUAUUUGGAA15                                                             (2) INFORMATION FOR SEQ ID NO:733:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:733:                                     UAUUUAUUUGGAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:734:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:734:                                     UAUUUAUUUGGAAGG15                                                             (2) INFORMATION FOR SEQ ID NO:735:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:735:                                     AUUUAUUUGGAAGGC15                                                             (2) INFORMATION FOR SEQ ID NO:736:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:736:                                     GGGGUGUCCUGGAGG15                                                             (2) INFORMATION FOR SEQ ID NO:737:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:737:                                     GCUGUCUUCAGACAG15                                                             (2) INFORMATION FOR SEQ ID NO:738:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:738:                                     GCUGUCUUCAGACAG15                                                             (2) INFORMATION FOR SEQ ID NO:739:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:739:                                     GACAUGUUUUCUGUG15                                                             (2) INFORMATION FOR SEQ ID NO:740:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:740:                                     ACAUGUUUUCUGUGA15                                                             (2) INFORMATION FOR SEQ ID NO:741:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:741:                                     CAUGUUUUCUGUGAA15                                                             (2) INFORMATION FOR SEQ ID NO:742:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:742:                                     AUGUUUUCUGUGAAA15                                                             (2) INFORMATION FOR SEQ ID NO:743:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:743:                                     AUGUUUUCUGUGAAA15                                                             (2) INFORMATION FOR SEQ ID NO:744:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:744:                                     GAGCUGUCCCCACCU15                                                             (2) INFORMATION FOR SEQ ID NO:745:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:745:                                     CUGGCCUCUCUACCU15                                                             (2) INFORMATION FOR SEQ ID NO:746:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:746:                                     GGCCUCUCUACCUUG15                                                             (2) INFORMATION FOR SEQ ID NO:747:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:747:                                     ACCUUGUUGCCUCCU15                                                             (2) INFORMATION FOR SEQ ID NO:748:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:748:                                     GCCUCCUCUUUUGCU15                                                             (2) INFORMATION FOR SEQ ID NO:749:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:749:                                     CUCCUCUUUUGCUUA15                                                             (2) INFORMATION FOR SEQ ID NO:750:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:750:                                     UCCUCUUUUGCUUAU15                                                             (2) INFORMATION FOR SEQ ID NO:751:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:751:                                     CCUCUUUUGCUUAUG15                                                             (2) INFORMATION FOR SEQ ID NO:752:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:752:                                     UUUUGCUUAUGUUUA15                                                             (2) INFORMATION FOR SEQ ID NO:753:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:753:                                     UUUGCUUAUGUUUAA15                                                             (2) INFORMATION FOR SEQ ID NO:754:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:754:                                     UUUGCUUAUGUUUAA15                                                             (2) INFORMATION FOR SEQ ID NO:755:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:755:                                     UUAUGUUUAAAACAA15                                                             (2) INFORMATION FOR SEQ ID NO:756:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:756:                                     AAAUAUUUAUCUAAC15                                                             (2) INFORMATION FOR SEQ ID NO:757:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:757:                                     ACCCAAUUGUCUUAA15                                                             (2) INFORMATION FOR SEQ ID NO:758:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:758:                                     CAAUUGUCUUAAUAA15                                                             (2) INFORMATION FOR SEQ ID NO:759:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:759:                                     AUUGUCUUAAUAACG15                                                             (2) INFORMATION FOR SEQ ID NO:760:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:760:                                     CGCUGAUUUGGUGAC15                                                             (2) INFORMATION FOR SEQ ID NO:761:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:761:                                     CGCUGAUUUGGUGAC15                                                             (2) INFORMATION FOR SEQ ID NO:762:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:762:                                     GCUGAUUUGGUGACC15                                                             (2) INFORMATION FOR SEQ ID NO:763:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:763:                                     GCUGAUUUGGUGACC15                                                             (2) INFORMATION FOR SEQ ID NO:764:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:764:                                     UGAACCUCUGCUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:765:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:765:                                     UGAACCUCUGCUCCC15                                                             (2) INFORMATION FOR SEQ ID NO:766:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:766:                                     CUCUGCUCCCCACGG15                                                             (2) INFORMATION FOR SEQ ID NO:767:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:767:                                     UGACUGUAAUUGCCC15                                                             (2) INFORMATION FOR SEQ ID NO:768:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:768:                                     CUGUAAUUGCCCUAC15                                                             (2) INFORMATION FOR SEQ ID NO:769:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:769:                                     GAGAAAUAAAGAUCG15                                                             (2) INFORMATION FOR SEQ ID NO:770:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:770:                                     UAAAGAUCGCUUAAA15                                                             (2) INFORMATION FOR SEQ ID NO:771:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:771:                                     UUAAAAUAAAAAACC15                                                             (2) INFORMATION FOR SEQ ID NO:772:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 15 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:772:                                     AGGGACUAGCCAGGA15                                                             (2) INFORMATION FOR SEQ ID NO:773:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:773:                                     UCCUGGCCUGAUGAGGCCGAAAGGCCGAAAGUCCCU36                                        (2) INFORMATION FOR SEQ ID NO:774:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:774:                                     UGGGAGCCUGAUGAGGCCGAAAGGCCGAAAUUUCCA36                                        (2) INFORMATION FOR SEQ ID NO:775:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:775:                                     GGGACAGCUGAUGAGGCCGAAAGGCCGAAACCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:776:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:776:                                     GGGACAGCUGAUGAGGCCGAAAGGCCGAAACCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:777:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:777:                                     AGGGACACUGAUGAGGCCGAAAGGCCGAAAACCUGC36                                        (2) INFORMATION FOR SEQ ID NO:778:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:778:                                     AGGGACACUGAUGAGGCCGAAAGGCCGAAAACCUGC36                                        (2) INFORMATION FOR SEQ ID NO:779:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:779:                                     UGAAAGGCUGAUGAGGCCGAAAGGCCGAAACAGAAC36                                        (2) INFORMATION FOR SEQ ID NO:780:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:780:                                     UGAGUGACUGAUGAGGCCGAAAGGCCGAAAGGGACA36                                        (2) INFORMATION FOR SEQ ID NO:781:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:781:                                     GUGAGUGCUGAUGAGGCCGAAAGGCCGAAAAGGGAC36                                        (2) INFORMATION FOR SEQ ID NO:782:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:782:                                     GUGAGUGCUGAUGAGGCCGAAAGGCCGAAAAGGGAC36                                        (2) INFORMATION FOR SEQ ID NO:783:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:783:                                     AGUGAGUCUGAUGAGGCCGAAAGGCCGAAAAAGGGA36                                        (2) INFORMATION FOR SEQ ID NO:784:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:784:                                     GGCCAGUCUGAUGAGGCCGAAAGGCCGAAAGUGAAA36                                        (2) INFORMATION FOR SEQ ID NO:785:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:785:                                     GGAGGGACUGAUGAGGCCGAAAGGCCGAAAUGUGGC36                                        (2) INFORMATION FOR SEQ ID NO:786:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:786:                                     CUGGAGGCUGAUGAGGCCGAAAGGCCGAAAGAUGUG36                                        (2) INFORMATION FOR SEQ ID NO:787:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:787:                                     CGUCGCGCUGAUGAGGCCGAAAGGCCGAAAUCAUGC36                                        (2) INFORMATION FOR SEQ ID NO:788:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:788:                                     UUUGGGGCUGAUGAGGCCGAAAGGCCGAAAGUGCCU36                                        (2) INFORMATION FOR SEQ ID NO:789:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:789:                                     AGUUCUGCUGAUGAGGCCGAAAGGCCGAAAAGCCCC36                                        (2) INFORMATION FOR SEQ ID NO:790:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:790:                                     AGUUCUGCUGAUGAGGCCGAAAGGCCGAAAAGCCCC36                                        (2) INFORMATION FOR SEQ ID NO:791:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:791:                                     CCGCCUGCUGAUGAGGCCGAAAGGCCGAAAGUUCUG36                                        (2) INFORMATION FOR SEQ ID NO:792:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:792:                                     CCGCCUGCUGAUGAGGCCGAAAGGCCGAAAGUUCUG36                                        (2) INFORMATION FOR SEQ ID NO:793:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:793:                                     UGAGACACUGAUGAGGCCGAAAGGCCGAAAGGCACC36                                        (2) INFORMATION FOR SEQ ID NO:794:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:794:                                     UGAGACACUGAUGAGGCCGAAAGGCCGAAAGGCACC36                                        (2) INFORMATION FOR SEQ ID NO:795:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:795:                                     AUGAGAACUGAUGAGGCCGAAAGGCCGAAAGGCUGA36                                        (2) INFORMATION FOR SEQ ID NO:796:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:796:                                     AUGAGAACUGAUGAGGCCGAAAGGCCGAAAGGCUGA36                                        (2) INFORMATION FOR SEQ ID NO:797:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:797:                                     GAAUGAGCUGAUGAGGCCGAAAGGCCGAAAGAGGCU36                                        (2) INFORMATION FOR SEQ ID NO:798:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:798:                                     GAAUGAGCUGAUGAGGCCGAAAGGCCGAAAGAGGCU36                                        (2) INFORMATION FOR SEQ ID NO:799:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:799:                                     GGAAUGACUGAUGAGGCCGAAAGGCCGAAAAGAGGC36                                        (2) INFORMATION FOR SEQ ID NO:800:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:800:                                     GGAAUGACUGAUGAGGCCGAAAGGCCGAAAAGAGGC36                                        (2) INFORMATION FOR SEQ ID NO:801:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:801:                                     CAGGAAUCUGAUGAGGCCGAAAGGCCGAAAGAAGAG36                                        (2) INFORMATION FOR SEQ ID NO:802:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:802:                                     AAGCAGGCUGAUGAGGCCGAAAGGCCGAAAUGAGAA36                                        (2) INFORMATION FOR SEQ ID NO:803:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:803:                                     CAAGCAGCUGAUGAGGCCGAAAGGCCGAAAAUGAGA36                                        (2) INFORMATION FOR SEQ ID NO:804:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:804:                                     CUGCCACCUGAUGAGGCCGAAAGGCCGAAAGCAGGA36                                        (2) INFORMATION FOR SEQ ID NO:805:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:805:                                     GACAGAACUGAUGAGGCCGAAAGGCCGAAAGCGUGG36                                        (2) INFORMATION FOR SEQ ID NO:806:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:806:                                     UAGACAGCUGAUGAGGCCGAAAGGCCGAAAGAGCGU36                                        (2) INFORMATION FOR SEQ ID NO:807:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:807:                                     GUAGACACUGAUGAGGCCGAAAGGCCGAAAAGAGCG36                                        (2) INFORMATION FOR SEQ ID NO:808:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:808:                                     UUCAGUACUGAUGAGGCCGAAAGGCCGAAACAGAAG36                                        (2) INFORMATION FOR SEQ ID NO:809:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:809:                                     AGUUCAGCUGAUGAGGCCGAAAGGCCGAAAGACAGA36                                        (2) INFORMATION FOR SEQ ID NO:810:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:810:                                     CACCCCGCUGAUGAGGCCGAAAGGCCGAAAGUUCAG36                                        (2) INFORMATION FOR SEQ ID NO:811:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:811:                                     UCACCCCCUGAUGAGGCCGAAAGGCCGAAAAGUUCA36                                        (2) INFORMATION FOR SEQ ID NO:812:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:812:                                     UCACCCCCUGAUGAGGCCGAAAGGCCGAAAAGUUCA36                                        (2) INFORMATION FOR SEQ ID NO:813:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:813:                                     GGGGACCCUGAUGAGGCCGAAAGGCCGAAAUCACCC36                                        (2) INFORMATION FOR SEQ ID NO:814:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:814:                                     GGGGACCCUGAUGAGGCCGAAAGGCCGAAAUCACCC36                                        (2) INFORMATION FOR SEQ ID NO:815:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:815:                                     AUUUGGGCUGAUGAGGCCGAAAGGCCGAAACUUCUC36                                        (2) INFORMATION FOR SEQ ID NO:816:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:816:                                     CUGAUGACUGAUGAGGCCGAAAGGCCGAAAGGGAGG36                                        (2) INFORMATION FOR SEQ ID NO:817:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:817:                                     AACUGAUCUGAUGAGGCCGAAAGGCCGAAAGAGGGA36                                        (2) INFORMATION FOR SEQ ID NO:818:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:818:                                     AACUGAUCUGAUGAGGCCGAAAGGCCGAAAGAGGGA36                                        (2) INFORMATION FOR SEQ ID NO:819:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:819:                                     UAGAACUCUGAUGAGGCCGAAAGGCCGAAAUGAGAG36                                        (2) INFORMATION FOR SEQ ID NO:820:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:820:                                     UGGGCCACUGAUGAGGCCGAAAGGCCGAAAGAACUG36                                        (2) INFORMATION FOR SEQ ID NO:821:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:821:                                     UGAGUGUCUGAUGAGGCCGAAAGGCCGAAAGGGUCU36                                        (2) INFORMATION FOR SEQ ID NO:822:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:822:                                     AUGAUCUCUGAUGAGGCCGAAAGGCCGAAAGUGUGA36                                        (2) INFORMATION FOR SEQ ID NO:823:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:823:                                     AGAAGAUCUGAUGAGGCCGAAAGGCCGAAAUCUGAG36                                        (2) INFORMATION FOR SEQ ID NO:824:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:824:                                     UUGAGAACUGAUGAGGCCGAAAGGCCGAAAUGAUCU36                                        (2) INFORMATION FOR SEQ ID NO:825:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:825:                                     UUUUGAGCUGAUGAGGCCGAAAGGCCGAAAGAUGAU36                                        (2) INFORMATION FOR SEQ ID NO:826:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:826:                                     UUUUGAGCUGAUGAGGCCGAAAGGCCGAAAGAUGAU36                                        (2) INFORMATION FOR SEQ ID NO:827:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:827:                                     AUUUUGACUGAUGAGGCCGAAAGGCCGAAAAGAUGA36                                        (2) INFORMATION FOR SEQ ID NO:828:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:828:                                     GAAUUUUCUGAUGAGGCCGAAAGGCCGAAAGAAGAU36                                        (2) INFORMATION FOR SEQ ID NO:829:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:829:                                     GAAUUUUCUGAUGAGGCCGAAAGGCCGAAAGAAGAU36                                        (2) INFORMATION FOR SEQ ID NO:830:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:830:                                     GAAUUUUCUGAUGAGGCCGAAAGGCCGAAAGAAGAU36                                        (2) INFORMATION FOR SEQ ID NO:831:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:831:                                     CGUGGGCCUGAUGAGGCCGAAAGGCCGAAACAGGCU36                                        (2) INFORMATION FOR SEQ ID NO:832:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:832:                                     GGUUUGCCUGAUGAGGCCGAAAGGCCGAAACGACGU36                                        (2) INFORMATION FOR SEQ ID NO:833:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:833:                                     UGGCCAGCUGAUGAGGCCGAAAGGCCGAAAGGGCGU36                                        (2) INFORMATION FOR SEQ ID NO:834:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:834:                                     GACAAGGCUGAUGAGGCCGAAAGGCCGAAACAACCC36                                        (2) INFORMATION FOR SEQ ID NO:835:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:835:                                     GACAAGGCUGAUGAGGCCGAAAGGCCGAAACAACCC36                                        (2) INFORMATION FOR SEQ ID NO:836:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:836:                                     AGUAGACCUGAUGAGGCCGAAAGGCCGAAAGGUACA36                                        (2) INFORMATION FOR SEQ ID NO:837:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:837:                                     GGGAGUACUGAUGAGGCCGAAAGGCCGAAACAAGGU36                                        (2) INFORMATION FOR SEQ ID NO:838:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:838:                                     CUGGGAGCUGAUGAGGCCGAAAGGCCGAAAGACAAG36                                        (2) INFORMATION FOR SEQ ID NO:839:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:839:                                     AACCUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:840:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:840:                                     AACCUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:841:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:841:                                     AACCUGGCUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:842:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:842:                                     UGAAGAGCUGAUGAGGCCGAAAGGCCGAAACCUGGG36                                        (2) INFORMATION FOR SEQ ID NO:843:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:843:                                     UUGAAGACUGAUGAGGCCGAAAGGCCGAAAACCUGG36                                        (2) INFORMATION FOR SEQ ID NO:844:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:844:                                     UUGAAGACUGAUGAGGCCGAAAGGCCGAAAACCUGG36                                        (2) INFORMATION FOR SEQ ID NO:845:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:845:                                     CCUUGAACUGAUGAGGCCGAAAGGCCGAAAGAACCU36                                        (2) INFORMATION FOR SEQ ID NO:846:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:846:                                     CCUUGAACUGAUGAGGCCGAAAGGCCGAAAGAACCU36                                        (2) INFORMATION FOR SEQ ID NO:847:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:847:                                     UCCCUUGCUGAUGAGGCCGAAAGGCCGAAAGAGAAC36                                        (2) INFORMATION FOR SEQ ID NO:848:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:848:                                     GUCCCUUCUGAUGAGGCCGAAAGGCCGAAAAGAGAA36                                        (2) INFORMATION FOR SEQ ID NO:849:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:849:                                     GAGCACGCUGAUGAGGCCGAAAGGCCGAAAGUCGGG36                                        (2) INFORMATION FOR SEQ ID NO:850:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:850:                                     GGGUGAGCUGAUGAGGCCGAAAGGCCGAAAGCACGU36                                        (2) INFORMATION FOR SEQ ID NO:851:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:851:                                     GGGUGAGCUGAUGAGGCCGAAAGGCCGAAAGCACGU36                                        (2) INFORMATION FOR SEQ ID NO:852:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:852:                                     UGUGGGUCUGAUGAGGCCGAAAGGCCGAAAGGAGCA36                                        (2) INFORMATION FOR SEQ ID NO:853:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:853:                                     AUCGGCUCUGAUGAGGCCGAAAGGCCGAAACGGUGU36                                        (2) INFORMATION FOR SEQ ID NO:854:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:854:                                     AUCGGCUCUGAUGAGGCCGAAAGGCCGAAACGGUGU36                                        (2) INFORMATION FOR SEQ ID NO:855:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:855:                                     GAUAGCACUGAUGAGGCCGAAAGGCCGAAAUCGGCU36                                        (2) INFORMATION FOR SEQ ID NO:856:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:856:                                     UAUGAGACUGAUGAGGCCGAAAGGCCGAAAGCAAAU36                                        (2) INFORMATION FOR SEQ ID NO:857:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:857:                                     GGUAUGACUGAUGAGGCCGAAAGGCCGAAAUAGCAA36                                        (2) INFORMATION FOR SEQ ID NO:858:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:858:                                     CUGGUAUCUGAUGAGGCCGAAAGGCCGAAAGAUAGC36                                        (2) INFORMATION FOR SEQ ID NO:859:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:859:                                     GGAGGUUCUGAUGAGGCCGAAAGGCCGAAACUUUCU36                                        (2) INFORMATION FOR SEQ ID NO:860:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:860:                                     CAGAGAGCUGAUGAGGCCGAAAGGCCGAAAGGUUGA36                                        (2) INFORMATION FOR SEQ ID NO:861:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:861:                                     CAGAGAGCUGAUGAGGCCGAAAGGCCGAAAGGUUGA36                                        (2) INFORMATION FOR SEQ ID NO:862:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:862:                                     CGGCAGACUGAUGAGGCCGAAAGGCCGAAAGGAGGU36                                        (2) INFORMATION FOR SEQ ID NO:863:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:863:                                     GACGGCACUGAUGAGGCCGAAAGGCCGAAAGAGGAG36                                        (2) INFORMATION FOR SEQ ID NO:864:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:864:                                     GGCUCUUCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                        (2) INFORMATION FOR SEQ ID NO:865:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:865:                                     GGCUCUUCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                        (2) INFORMATION FOR SEQ ID NO:866:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:866:                                     GGCUCUUCUGAUGAGGCCGAAAGGCCGAAACGGCAG36                                        (2) INFORMATION FOR SEQ ID NO:867:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:867:                                     GGGCUCACUGAUGAGGCCGAAAGGCCGAAACCAGGG36                                        (2) INFORMATION FOR SEQ ID NO:868:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:868:                                     GGGCUCACUGAUGAGGCCGAAAGGCCGAAACCAGGG36                                        (2) INFORMATION FOR SEQ ID NO:869:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:869:                                     CCAGGUACUGAUGAGGCCGAAAGGCCGAAAUGGGCU36                                        (2) INFORMATION FOR SEQ ID NO:870:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:870:                                     UCCCAGGCUGAUGAGGCCGAAAGGCCGAAAUAUGGG36                                        (2) INFORMATION FOR SEQ ID NO:871:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:871:                                     GCUGGAACUGAUGAGGCCGAAAGGCCGAAACUCCUC36                                        (2) INFORMATION FOR SEQ ID NO:872:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:872:                                     GCUGGAACUGAUGAGGCCGAAAGGCCGAAACUCCUC36                                        (2) INFORMATION FOR SEQ ID NO:873:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:873:                                     CAGCUGGCUGAUGAGGCCGAAAGGCCGAAAGACUCC36                                        (2) INFORMATION FOR SEQ ID NO:874:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:874:                                     CCAGCUGCUGAUGAGGCCGAAAGGCCGAAAAGACUC36                                        (2) INFORMATION FOR SEQ ID NO:875:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:875:                                     CAGCGCUCUGAUGAGGCCGAAAGGCCGAAAGUUGGU36                                        (2) INFORMATION FOR SEQ ID NO:876:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:876:                                     GCAGAUUCUGAUGAGGCCGAAAGGCCGAAACCUCAG36                                        (2) INFORMATION FOR SEQ ID NO:877:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:877:                                     UUGGGCACUGAUGAGGCCGAAAGGCCGAAAUUGACC36                                        (2) INFORMATION FOR SEQ ID NO:878:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:878:                                     GUCUAAGCUGAUGAGGCCGAAAGGCCGAAACUUGGG36                                        (2) INFORMATION FOR SEQ ID NO:879:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:879:                                     CAAAGUCCUGAUGAGGCCGAAAGGCCGAAAAGUACU36                                        (2) INFORMATION FOR SEQ ID NO:880:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:880:                                     CUCCGCACUGAUGAGGCCGAAAGGCCGAAAGUCUAA36                                        (2) INFORMATION FOR SEQ ID NO:881:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:881:                                     ACUCCGCCUGAUGAGGCCGAAAGGCCGAAAAGUCUA36                                        (2) INFORMATION FOR SEQ ID NO:882:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:882:                                     CUGCCCGCUGAUGAGGCCGAAAGGCCGAAACUCCGC36                                        (2) INFORMATION FOR SEQ ID NO:883:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:883:                                     CAAAGUACUGAUGAGGCCGAAAGGCCGAAACCUGCC36                                        (2) INFORMATION FOR SEQ ID NO:884:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:884:                                     UCCAAAGCUGAUGAGGCCGAAAGGCCGAAAGACCUG36                                        (2) INFORMATION FOR SEQ ID NO:885:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:885:                                     UCCAAAGCUGAUGAGGCCGAAAGGCCGAAAGACCUG36                                        (2) INFORMATION FOR SEQ ID NO:886:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:886:                                     UCCAAAGCUGAUGAGGCCGAAAGGCCGAAAGACCUG36                                        (2) INFORMATION FOR SEQ ID NO:887:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:887:                                     GACUCCACUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:888:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:888:                                     UGACUCCCUGAUGAGGCCGAAAGGCCGAAAAGUAGA36                                        (2) INFORMATION FOR SEQ ID NO:889:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:889:                                     GAGCAAUCUGAUGAGGCCGAAAGGCCGAAACUCCAA36                                        (2) INFORMATION FOR SEQ ID NO:890:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:890:                                     ACAGAGCCUGAUGAGGCCGAAAGGCCGAAAUGACUC36                                        (2) INFORMATION FOR SEQ ID NO:891:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:891:                                     GGGUAGACUGAUGAGGCCGAAAGGCCGAAAAUGGAU36                                        (2) INFORMATION FOR SEQ ID NO:892:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:892:                                     GGCUGGGCUGAUGAGGCCGAAAGGCCGAAAGAGAAU36                                        (2) INFORMATION FOR SEQ ID NO:893:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:893:                                     GGGGUCACUGAUGAGGCCGAAAGGCCGAAAGUGGGG36                                        (2) INFORMATION FOR SEQ ID NO:894:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:894:                                     GGGGUCACUGAUGAGGCCGAAAGGCCGAAAGUGGGG36                                        (2) INFORMATION FOR SEQ ID NO:895:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:895:                                     GGGGUCACUGAUGAGGCCGAAAGGCCGAAAGUGGGG36                                        (2) INFORMATION FOR SEQ ID NO:896:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:896:                                     CAGAGUACUGAUGAGGCCGAAAGGCCGAAAGGGGUC36                                        (2) INFORMATION FOR SEQ ID NO:897:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:897:                                     UCAGAGUCUGAUGAGGCCGAAAGGCCGAAAAGGGGU36                                        (2) INFORMATION FOR SEQ ID NO:898:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:898:                                     GGGGUCACUGAUGAGGCCGAAAGGCCGAAAGUAAAG36                                        (2) INFORMATION FOR SEQ ID NO:899:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:899:                                     GACAAUACUGAUGAGGCCGAAAGGCCGAAAGGGGUC36                                        (2) INFORMATION FOR SEQ ID NO:900:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:900:                                     GACAAUACUGAUGAGGCCGAAAGGCCGAAAGGGGUC36                                        (2) INFORMATION FOR SEQ ID NO:901:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:901:                                     AGUAGACCUGAUGAGGCCGAAAGGCCGAAAUAAAGG36                                        (2) INFORMATION FOR SEQ ID NO:902:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:902:                                     CUCUGAGCUGAUGAGGCCGAAAGGCCGAAAGUAGAC36                                        (2) INFORMATION FOR SEQ ID NO:903:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:903:                                     GGGCUCUCUGAUGAGGCCGAAAGGCCGAAAGGAGUA36                                        (2) INFORMATION FOR SEQ ID NO:904:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:904:                                     CCUUUCUCUGAUGAGGCCGAAAGGCCGAAAGUUAGA36                                        (2) INFORMATION FOR SEQ ID NO:905:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:905:                                     CCUUUCUCUGAUGAGGCCGAAAGGCCGAAAGUUAGA36                                        (2) INFORMATION FOR SEQ ID NO:906:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:906:                                     CCCUUUCCUGAUGAGGCCGAAAGGCCGAAAAGUUAG36                                        (2) INFORMATION FOR SEQ ID NO:907:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:907:                                     GAGCCAUCUGAUGAGGCCGAAAGGCCGAAAUCCCCU36                                        (2) INFORMATION FOR SEQ ID NO:908:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:908:                                     GAGCCAUCUGAUGAGGCCGAAAGGCCGAAAUCCCCU36                                        (2) INFORMATION FOR SEQ ID NO:909:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:909:                                     UGAGCCACUGAUGAGGCCGAAAGGCCGAAAAUCCCC36                                        (2) INFORMATION FOR SEQ ID NO:910:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:910:                                     AGAGUUGCUGAUGAGGCCGAAAGGCCGAAACUCUGA36                                        (2) INFORMATION FOR SEQ ID NO:911:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:911:                                     AAGCUCUCUGAUGAGGCCGAAAGGCCGAAAGCACAG36                                        (2) INFORMATION FOR SEQ ID NO:912:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:912:                                     UUGUUGACUGAUGAGGCCGAAAGGCCGAAAGCUCUG36                                        (2) INFORMATION FOR SEQ ID NO:913:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:913:                                     GUUGUUGCUGAUGAGGCCGAAAGGCCGAAAAGCUCU36                                        (2) INFORMATION FOR SEQ ID NO:914:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:914:                                     AGUUGUUCUGAUGAGGCCGAAAGGCCGAAAAAGCUC36                                        (2) INFORMATION FOR SEQ ID NO:915:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:915:                                     UGCAUGACUGAUGAGGCCGAAAGGCCGAAAGGCCCA36                                        (2) INFORMATION FOR SEQ ID NO:916:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:916:                                     CCCAUUUCUGAUGAGGCCGAAAGGCCGAAAGUCCUU36                                        (2) INFORMATION FOR SEQ ID NO:917:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:917:                                     AUUCGGACUGAUGAGGCCGAAAGGCCGAAAGCCCAU36                                        (2) INFORMATION FOR SEQ ID NO:918:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:918:                                     AAUUCGGCUGAUGAGGCCGAAAGGCCGAAAAGCCCA36                                        (2) INFORMATION FOR SEQ ID NO:919:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:919:                                     GAAUUCGCUGAUGAGGCCGAAAGGCCGAAAAAGCCC36                                        (2) INFORMATION FOR SEQ ID NO:920:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:920:                                     CUCCAGUCUGAUGAGGCCGAAAGGCCGAAAAUUCGG36                                        (2) INFORMATION FOR SEQ ID NO:921:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:921:                                     AGGAAUGCUGAUGAGGCCGAAAGGCCGAAACAUUCG36                                        (2) INFORMATION FOR SEQ ID NO:922:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:922:                                     GCAACCUCUGAUGAGGCCGAAAGGCCGAAACCACUC36                                        (2) INFORMATION FOR SEQ ID NO:923:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:923:                                     UCAUUCUCUGAUGAGGCCGAAAGGCCGAAAGACAGA36                                        (2) INFORMATION FOR SEQ ID NO:924:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:924:                                     AAGGCCUCUGAUGAGGCCGAAAGGCCGAAAGAUCUU36                                        (2) INFORMATION FOR SEQ ID NO:925:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:925:                                     AGGUAGGCUGAUGAGGCCGAAAGGCCGAAAGGCCUG36                                        (2) INFORMATION FOR SEQ ID NO:926:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:926:                                     AAGGUAGCUGAUGAGGCCGAAAGGCCGAAAAGGCCU36                                        (2) INFORMATION FOR SEQ ID NO:927:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:927:                                     CUGAAGGCUGAUGAGGCCGAAAGGCCGAAAGGAAGG36                                        (2) INFORMATION FOR SEQ ID NO:928:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:928:                                     AGGUCUGCUGAUGAGGCCGAAAGGCCGAAAGGUAGG36                                        (2) INFORMATION FOR SEQ ID NO:929:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:929:                                     AGGUCUGCUGAUGAGGCCGAAAGGCCGAAAGGUAGG36                                        (2) INFORMATION FOR SEQ ID NO:930:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:930:                                     AGGUCUGCUGAUGAGGCCGAAAGGCCGAAAGGUAGG36                                        (2) INFORMATION FOR SEQ ID NO:931:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:931:                                     AGGUCUGCUGAUGAGGCCGAAAGGCCGAAAGGUAGG36                                        (2) INFORMATION FOR SEQ ID NO:932:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:932:                                     AAGGUCUCUGAUGAGGCCGAAAGGCCGAAAAGGUAG36                                        (2) INFORMATION FOR SEQ ID NO:933:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:933:                                     AAGGUCUCUGAUGAGGCCGAAAGGCCGAAAAGGUAG36                                        (2) INFORMATION FOR SEQ ID NO:934:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:934:                                     GUCUGGACUGAUGAGGCCGAAAGGCCGAAAGGUCUG36                                        (2) INFORMATION FOR SEQ ID NO:935:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:935:                                     GUCUGGACUGAUGAGGCCGAAAGGCCGAAAGGUCUG36                                        (2) INFORMATION FOR SEQ ID NO:936:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:936:                                     AGUCUGGCUGAUGAGGCCGAAAGGCCGAAAAGGUCU36                                        (2) INFORMATION FOR SEQ ID NO:937:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:937:                                     AGUCUGGCUGAUGAGGCCGAAAGGCCGAAAAGGUCU36                                        (2) INFORMATION FOR SEQ ID NO:938:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:938:                                     GAGUCUGCUGAUGAGGCCGAAAGGCCGAAAAAGGUC36                                        (2) INFORMATION FOR SEQ ID NO:939:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:939:                                     CCUCAGGCUGAUGAGGCCGAAAGGCCGAAAAGAGUC36                                        (2) INFORMATION FOR SEQ ID NO:940:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:940:                                     CUGUGAGCUGAUGAGGCCGAAAGGCCGAAAAGGCUG36                                        (2) INFORMATION FOR SEQ ID NO:941:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:941:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAGGGGGG36                                        (2) INFORMATION FOR SEQ ID NO:942:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:942:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAGGGGGG36                                        (2) INFORMATION FOR SEQ ID NO:943:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:943:                                     AUAUAAACUGAUGAGGCCGAAAGGCCGAAAGAGGGG36                                        (2) INFORMATION FOR SEQ ID NO:944:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:944:                                     AAAUAUACUGAUGAGGCCGAAAGGCCGAAAUAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:945:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:945:                                     AAAUAUACUGAUGAGGCCGAAAGGCCGAAAUAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:946:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:946:                                     CAAAUAUCUGAUGAGGCCGAAAGGCCGAAAAUAGAG36                                        (2) INFORMATION FOR SEQ ID NO:947:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:947:                                     GCAAAUACUGAUGAGGCCGAAAGGCCGAAAAAUAGA36                                        (2) INFORMATION FOR SEQ ID NO:948:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:948:                                     AAGUGCACUGAUGAGGCCGAAAGGCCGAAAUAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:949:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:949:                                     AAGUGCACUGAUGAGGCCGAAAGGCCGAAAUAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:950:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:950:                                     UAAGUGCCUGAUGAGGCCGAAAGGCCGAAAAUAUAA36                                        (2) INFORMATION FOR SEQ ID NO:951:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:951:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAGUGCAA36                                        (2) INFORMATION FOR SEQ ID NO:952:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:952:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAGUG36                                        (2) INFORMATION FOR SEQ ID NO:953:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:953:                                     UAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAGU36                                        (2) INFORMATION FOR SEQ ID NO:954:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:954:                                     AAUAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:955:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:955:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:956:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:956:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:957:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:957:                                     UAAAUAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:958:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:958:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:959:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:959:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:960:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:960:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:961:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:961:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:962:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:962:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:963:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:963:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:964:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:964:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:965:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:965:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:966:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:966:                                     AUAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAUAA36                                        (2) INFORMATION FOR SEQ ID NO:967:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:967:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:968:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:968:                                     AAUAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAUA36                                        (2) INFORMATION FOR SEQ ID NO:969:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:969:                                     UAAUAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:970:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:970:                                     AAUAAUACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:971:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:971:                                     AAAUAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:972:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:972:                                     UAAAUAACUGAUGAGGCCGAAAGGCCGAAAAAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:973:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:973:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAU36                                        (2) INFORMATION FOR SEQ ID NO:974:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:974:                                     GCAAAUACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:975:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:975:                                     AGCAAAUCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:976:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:976:                                     AAGCAAACUGAUGAGGCCGAAAGGCCGAAAAAUAAA36                                        (2) INFORMATION FOR SEQ ID NO:977:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:977:                                     AUAAGCACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:978:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:978:                                     CAUAAGCCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:979:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:979:                                     CAUUCAUCUGAUGAGGCCGAAAGGCCGAAAGCAAAU36                                        (2) INFORMATION FOR SEQ ID NO:980:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:980:                                     ACAUUCACUGAUGAGGCCGAAAGGCCGAAAAGCAAA36                                        (2) INFORMATION FOR SEQ ID NO:981:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:981:                                     AAAUAAACUGAUGAGGCCGAAAGGCCGAAACAUUCA36                                        (2) INFORMATION FOR SEQ ID NO:982:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:982:                                     CCAAAUACUGAUGAGGCCGAAAGGCCGAAAUACAUU36                                        (2) INFORMATION FOR SEQ ID NO:983:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:983:                                     UCCAAAUCUGAUGAGGCCGAAAGGCCGAAAAUACAU36                                        (2) INFORMATION FOR SEQ ID NO:984:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:984:                                     UUCCAAACUGAUGAGGCCGAAAGGCCGAAAAAUACA36                                        (2) INFORMATION FOR SEQ ID NO:985:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:985:                                     CCUUCCACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:986:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:986:                                     CCUUCCACUGAUGAGGCCGAAAGGCCGAAAUAAAUA36                                        (2) INFORMATION FOR SEQ ID NO:987:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:987:                                     GCCUUCCCUGAUGAGGCCGAAAGGCCGAAAAUAAAU36                                        (2) INFORMATION FOR SEQ ID NO:988:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:988:                                     CCUCCAGCUGAUGAGGCCGAAAGGCCGAAACACCCC36                                        (2) INFORMATION FOR SEQ ID NO:989:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:989:                                     CUGUCUGCUGAUGAGGCCGAAAGGCCGAAAGACAGC36                                        (2) INFORMATION FOR SEQ ID NO:990:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:990:                                     CUGUCUGCUGAUGAGGCCGAAAGGCCGAAAGACAGC36                                        (2) INFORMATION FOR SEQ ID NO:991:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:991:                                     CACAGAACUGAUGAGGCCGAAAGGCCGAAACAUGUC36                                        (2) INFORMATION FOR SEQ ID NO:992:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:992:                                     UCACAGACUGAUGAGGCCGAAAGGCCGAAAACAUGU36                                        (2) INFORMATION FOR SEQ ID NO:993:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:993:                                     UUCACAGCUGAUGAGGCCGAAAGGCCGAAAAACAUG36                                        (2) INFORMATION FOR SEQ ID NO:994:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:994:                                     UUUCACACUGAUGAGGCCGAAAGGCCGAAAAAACAU36                                        (2) INFORMATION FOR SEQ ID NO:995:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:995:                                     UUUCACACUGAUGAGGCCGAAAGGCCGAAAAAACAU36                                        (2) INFORMATION FOR SEQ ID NO:996:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:996:                                     AGGUGGGCUGAUGAGGCCGAAAGGCCGAAACAGCUC36                                        (2) INFORMATION FOR SEQ ID NO:997:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:997:                                     AGGUAGACUGAUGAGGCCGAAAGGCCGAAAGGCCAG36                                        (2) INFORMATION FOR SEQ ID NO:998:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:998:                                     CAAGGUACUGAUGAGGCCGAAAGGCCGAAAGAGGCC36                                        (2) INFORMATION FOR SEQ ID NO:999:                                            (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:999:                                     AACAAGGCUGAUGAGGCCGAAAGGCCGAAAGAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:1000:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1000:                                    AGGAGGCCUGAUGAGGCCGAAAGGCCGAAACAAGGU36                                        (2) INFORMATION FOR SEQ ID NO:1001:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1001:                                    AGCAAAACUGAUGAGGCCGAAAGGCCGAAAGGAGGC36                                        (2) INFORMATION FOR SEQ ID NO:1002:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1002:                                    UAAGCAACUGAUGAGGCCGAAAGGCCGAAAGAGGAG36                                        (2) INFORMATION FOR SEQ ID NO:1003:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1003:                                    AUAAGCACUGAUGAGGCCGAAAGGCCGAAAAGAGGA36                                        (2) INFORMATION FOR SEQ ID NO:1004:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1004:                                    CAUAAGCCUGAUGAGGCCGAAAGGCCGAAAAAGAGG36                                        (2) INFORMATION FOR SEQ ID NO:1005:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1005:                                    UAAACAUCUGAUGAGGCCGAAAGGCCGAAAGCAAAA36                                        (2) INFORMATION FOR SEQ ID NO:1006:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1006:                                    UUAAACACUGAUGAGGCCGAAAGGCCGAAAAGCAAA36                                        (2) INFORMATION FOR SEQ ID NO:1007:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1007:                                    UUAAACACUGAUGAGGCCGAAAGGCCGAAAAGCAAA36                                        (2) INFORMATION FOR SEQ ID NO:1008:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1008:                                    UUGUUUUCUGAUGAGGCCGAAAGGCCGAAAACAUAA36                                        (2) INFORMATION FOR SEQ ID NO:1009:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1009:                                    GUUAGAUCUGAUGAGGCCGAAAGGCCGAAAAUAUUU36                                        (2) INFORMATION FOR SEQ ID NO:1010:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1010:                                    UUAAGACCUGAUGAGGCCGAAAGGCCGAAAUUGGGU36                                        (2) INFORMATION FOR SEQ ID NO:1011:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1011:                                    UUAUUAACUGAUGAGGCCGAAAGGCCGAAACAAUUG36                                        (2) INFORMATION FOR SEQ ID NO:1012:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1012:                                    CGUUAUUCUGAUGAGGCCGAAAGGCCGAAAGACAAU36                                        (2) INFORMATION FOR SEQ ID NO:1013:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1013:                                    GUCACCACUGAUGAGGCCGAAAGGCCGAAAUCAGCG36                                        (2) INFORMATION FOR SEQ ID NO:1014:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1014:                                    GUCACCACUGAUGAGGCCGAAAGGCCGAAAUCAGCG36                                        (2) INFORMATION FOR SEQ ID NO:1015:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1015:                                    GGUCACCCUGAUGAGGCCGAAAGGCCGAAAAUCAGC36                                        (2) INFORMATION FOR SEQ ID NO:1016:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1016:                                    GGUCACCCUGAUGAGGCCGAAAGGCCGAAAAUCAGC36                                        (2) INFORMATION FOR SEQ ID NO:1017:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1017:                                    GGGAGCACUGAUGAGGCCGAAAGGCCGAAAGGUUCA36                                        (2) INFORMATION FOR SEQ ID NO:1018:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1018:                                    GGGAGCACUGAUGAGGCCGAAAGGCCGAAAGGUUCA36                                        (2) INFORMATION FOR SEQ ID NO:1019:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1019:                                    CCGUGGGCUGAUGAGGCCGAAAGGCCGAAAGCAGAG36                                        (2) INFORMATION FOR SEQ ID NO:1020:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1020:                                    GGGCAAUCUGAUGAGGCCGAAAGGCCGAAACAGUCA36                                        (2) INFORMATION FOR SEQ ID NO:1021:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1021:                                    GUAGGGCCUGAUGAGGCCGAAAGGCCGAAAUUACAG36                                        (2) INFORMATION FOR SEQ ID NO:1022:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1022:                                    CGAUCUUCUGAUGAGGCCGAAAGGCCGAAAUUUCUC36                                        (2) INFORMATION FOR SEQ ID NO:1023:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1023:                                    UUUAAGCCUGAUGAGGCCGAAAGGCCGAAAUCUUUA36                                        (2) INFORMATION FOR SEQ ID NO:1024:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 36 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1024:                                    GGUUUUUCUGAUGAGGCCGAAAGGCCGAAAUUUUAA36                                        (2) INFORMATION FOR SEQ ID NO:1025:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1025:                                    AGCCGUGGAGAAGUAUGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1026:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1026:                                    GAGGGUGGAGAAGUGGGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1027:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1027:                                    GGAGAAGAAGAAGAGGAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1028:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1028:                                    CUGCCACGAGAAGGAAGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1029:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1029:                                    GUGCAGCAAGAAGAAGAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1030:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1030:                                    CAAAGUGCAGAAGGCAGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1031:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1031:                                    CCUCUGGGAGAAGAUCACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1032:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1032:                                    GGCCAGAGAGAAGAUUAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1033:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1033:                                    AGAAGAUGAGAAGACUGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1034:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1034:                                    GCCACUGGAGAAGCCCCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1035:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1035:                                    AUUGGCCCAGAAGUUCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1036:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1036:                                    GCACCACCAGAAGGUUAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1037:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1037:                                    GGUGGAGGAGAAGCCUUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1038:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1038:                                    GGCGAUGCAGAAGAUGGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1039:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1039:                                    UGGUAGGAAGAAGCGAUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1040:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1040:                                    UGACCUUGAGAAGGUAGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1041:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1041:                                    CCUUCUCCAGAAGGAAGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1042:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1042:                                    AGCGCUGAAGAAGUCACCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1043:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1043:                                    GAUAGUCGAGAAGAUUGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1044:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1044:                                    UCGAGAUAAGAAGGCCGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1045:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1045:                                    GGGAUUGGAGAAGGGGAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1046:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1046:                                    GGGAUCAAAGAAGUAGGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1047:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1047:                                    CUGGAAACAGAAGGAGAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1048:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1048:                                    UCAAGGAAAGAAGGAAACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1049:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1049:                                    AUGGGGAGAGAAGGGCUCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1050:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1050:                                    AUAGAGGGAGAAGGCUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1051:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1051:                                    AUACAUUCAGAAGUAAAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1052:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1052:                                    UGAGCCAAAGAAGCUCCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1053:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1053:                                    UACAUGGGAGAAGCCUAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1054:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1054:                                    ACAACUUAAGAAGAUAAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1055:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1055:                                    GUCACCAAAGAAGCAUUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1056:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1056:                                    CCCUGGGGAGAAGAGGCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1057:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1057:                                    GAAUAGUAAGAAGAUUACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1058:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1058:                                    ACAUACUGACCCACGGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1059:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1059:                                    ACCCACGGCUCCACCCUC18                                                          (2) INFORMATION FOR SEQ ID NO:1060:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1060:                                    UUCCUCAGCCUCUUCUCC18                                                          (2) INFORMATION FOR SEQ ID NO:1061:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1061:                                    CCUUCCUGAUCGUGGCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1062:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1062:                                    CUCUUCUGCCUGCUGCAC18                                                          (2) INFORMATION FOR SEQ ID NO:1063:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1063:                                    UCUGCCUGCUGCACUUUG18                                                          (2) INFORMATION FOR SEQ ID NO:1064:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1064:                                    GUGAUCGGCCCCCAGAGG18                                                          (2) INFORMATION FOR SEQ ID NO:1065:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1065:                                    CUAAUCAGCCCUCUGGCC18                                                          (2) INFORMATION FOR SEQ ID NO:1066:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1066:                                    GCAGUCAGAUCAUCUUCU18                                                          (2) INFORMATION FOR SEQ ID NO:1067:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1067:                                    AGGGGCAGCUCCAGUGGC18                                                          (2) INFORMATION FOR SEQ ID NO:1068:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1068:                                    CUGAACCGCCGGGCCAAU18                                                          (2) INFORMATION FOR SEQ ID NO:1069:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1069:                                    AUAACCAGCUGGUGGUGC18                                                          (2) INFORMATION FOR SEQ ID NO:1070:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1070:                                    CAAGGCUGCCCCUCCACC18                                                          (2) INFORMATION FOR SEQ ID NO:1071:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1071:                                    ACCAUCAGCCGCAUCGCC18                                                          (2) INFORMATION FOR SEQ ID NO:1072:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1072:                                    CAUCGCCGUCUCCUACCA18                                                          (2) INFORMATION FOR SEQ ID NO:1073:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1073:                                    CCUACCAGACCAAGGUCA18                                                          (2) INFORMATION FOR SEQ ID NO:1074:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1074:                                    UCUUCCAGCUGGAGAAGG18                                                          (2) INFORMATION FOR SEQ ID NO:1075:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1075:                                    GGUGACCGACUCAGCGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1076:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1076:                                    UCAAUCGGCCCGACUAUC18                                                          (2) INFORMATION FOR SEQ ID NO:1077:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1077:                                    UCGGCCCGACUAUCUCGA18                                                          (2) INFORMATION FOR SEQ ID NO:1078:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1078:                                    CUCCCCUGCCCCAAUCCC18                                                          (2) INFORMATION FOR SEQ ID NO:1079:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1079:                                    GCCUACAGCUUUGAUCCC18                                                          (2) INFORMATION FOR SEQ ID NO:1080:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1080:                                    CUCUCCAGAUGUUUCCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1081:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1081:                                    GUUUCCAGACUUCCUUGA18                                                          (2) INFORMATION FOR SEQ ID NO:1082:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1082:                                    GAGCCCAGCCCUCCCCAU18                                                          (2) INFORMATION FOR SEQ ID NO:1083:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1083:                                    GGAGCCAGCUCCCUCUAU18                                                          (2) INFORMATION FOR SEQ ID NO:1084:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1084:                                    AUUUACAGAUGAAUGUAU18                                                          (2) INFORMATION FOR SEQ ID NO:1085:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1085:                                    AGGAGCUGCCUUGGCUCA18                                                          (2) INFORMATION FOR SEQ ID NO:1086:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1086:                                    AUAGGCUGUUCCCAUGUA18                                                          (2) INFORMATION FOR SEQ ID NO:1087:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1087:                                    AUUAUCUGAUUAAGUUGU18                                                          (2) INFORMATION FOR SEQ ID NO:1088:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1088:                                    CAAUGCUGAUUUGGUGAC18                                                          (2) INFORMATION FOR SEQ ID NO:1089:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1089:                                    GGCCUCUGCUCCCCAGGG18                                                          (2) INFORMATION FOR SEQ ID NO:1090:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1090:                                    GUAAUCGGCCUACUAUUC18                                                          (2) INFORMATION FOR SEQ ID NO:1091:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1091:                                    GUGAAAGGAGAAGAACCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1092:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1092:                                    UGAGAAGAAGAAGAGACAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1093:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1093:                                    CUGCCACAAGAAGGAAUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1094:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1094:                                    GUUCAGUAAGAAGAAGAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1095:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1095:                                    CCUUUGGGAGAAGAUCACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1096:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1096:                                    GGCCAUAGAGAAGAUGAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1097:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1097:                                    GUGUGAGGAGAAGGGCCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1098:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1098:                                    AGAAGAUGAGAAGAGUGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1099:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1099:                                    GCCACUCCAGAAGCUCCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1100:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1100:                                    AACCCAUCAGAAGGCACCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1101:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1101:                                    UACAACCCAGAAGCUGGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1102:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1102:                                    GUAGUCGGAGAAGCCUUGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1103:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1103:                                    AGCACGUAAGAAGGGCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1104:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1104:                                    AGCAAAUCAGAAGACGGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1105:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1105:                                    GAUAGCAAAGAAGCUGACACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1106:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1106:                                    CUCUUGACAGAAGAGAGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1107:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1107:                                    GUCCUUGGAGAAGGGGCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1108:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1108:                                    CCUUCUCCAGAAGGAAGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1109:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1109:                                    AGUACUUGAGAAGAUUGAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1110:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1110:                                    AGAGUGGGAGAAGGGUAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1111:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1111:                                    GUAAAGGGAGAAGAGUGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1112:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1112:                                    AUAAAGGGAGAAGAGUAAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1113:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1113:                                    AGGACACAAGAAGGGGGCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1114:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1114:                                    CAUUCUGAAGAAGAGGCAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1115:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1115:                                    CUGGAAAGAGAAGAAGGUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1116:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1116:                                    AGGGAAGAAGAAGGAAAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1117:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1117:                                    GUGAGGAAAGAAGUGCAUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1118:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1118:                                    UAGAGGGGAGAAGGCUCUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1119:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1119:                                    UGUCUGAAAGAAGCUUCCACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1120:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1120:                                    CAGGUGGGAGAAGCUCAGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1121:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1121:                                    GUCACCAAAGAAGCGUUAACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1122:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1122:                                    GAUGUAGCAGAAGCCUGGACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1123:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 54 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1123:                                    CCGUGGGGAGAAGAGGUUACCAGAGAAACACACGUUGUGGUACAUUACCUGGUA54                      (2) INFORMATION FOR SEQ ID NO:1124:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1124:                                    AGGUUCUGUCCCUUUCAC18                                                          (2) INFORMATION FOR SEQ ID NO:1125:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1125:                                    UGUCUCAGCCUCUUCUCA18                                                          (2) INFORMATION FOR SEQ ID NO:1126:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1126:                                    CAUUCCUGCUUGUGGCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1127:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1127:                                    CUCUUCUGUCUACUGAAC18                                                          (2) INFORMATION FOR SEQ ID NO:1128:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1128:                                    GUGAUCGGUCCCCAAAGG18                                                          (2) INFORMATION FOR SEQ ID NO:1129:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1129:                                    CUCAUCAGUUCUAUGGCC18                                                          (2) INFORMATION FOR SEQ ID NO:1130:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1130:                                    UGGCCCAGACCCUCACAC18                                                          (2) INFORMATION FOR SEQ ID NO:1131:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1131:                                    ACACUCAGAUCAUCUUCU18                                                          (2) INFORMATION FOR SEQ ID NO:1132:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1132:                                    AGGAGCAGCUGGAGUGGC18                                                          (2) INFORMATION FOR SEQ ID NO:1133:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1133:                                    GGUGCCAGCCGAUGGGUU18                                                          (2) INFORMATION FOR SEQ ID NO:1134:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1134:                                    GCCAGCCGAUGGGUUGUA18                                                          (2) INFORMATION FOR SEQ ID NO:1135:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1135:                                    CAAGGCUGCCCCGACUAC18                                                          (2) INFORMATION FOR SEQ ID NO:1136:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1136:                                    CUGCCCCGACUACGUGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1137:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1137:                                    ACCGUCAGCCGAUUUGCU18                                                          (2) INFORMATION FOR SEQ ID NO:1138:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1138:                                    GUCAGCCGAUUUGCUAUC18                                                          (2) INFORMATION FOR SEQ ID NO:1139:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1139:                                    CCUCUCUGCCGUCAAGAG18                                                          (2) INFORMATION FOR SEQ ID NO:1140:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1140:                                    AGCCCCUGCCCCAAGGAC18                                                          (2) INFORMATION FOR SEQ ID NO:1141:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1141:                                    UCUUCCAGCUGGAGAAGG18                                                          (2) INFORMATION FOR SEQ ID NO:1142:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1142:                                    UCAAUCUGCCCAAGUACU18                                                          (2) INFORMATION FOR SEQ ID NO:1143:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1143:                                    CUACCCAGCCCCCACUCU18                                                          (2) INFORMATION FOR SEQ ID NO:1144:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1144:                                    CCACUCUGACCCCUUUAC18                                                          (2) INFORMATION FOR SEQ ID NO:1145:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1145:                                    UUACUCUGACCCCUUUAU18                                                          (2) INFORMATION FOR SEQ ID NO:1146:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1146:                                    GCCCCCAGUCUGUGUCCU18                                                          (2) INFORMATION FOR SEQ ID NO:1147:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1147:                                    UGCCUCUGUCUCAGAAUG18                                                          (2) INFORMATION FOR SEQ ID NO:1148:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1148:                                    ACCUUCAGACCUUUCCAG18                                                          (2) INFORMATION FOR SEQ ID NO:1149:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1149:                                    CUUUCCAGACUCUUCCCU18                                                          (2) INFORMATION FOR SEQ ID NO:1150:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1150:                                    AUGCACAGCCUUCCUCAC18                                                          (2) INFORMATION FOR SEQ ID NO:1151:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1151:                                    AGAGCCAGCCCCCCUCUA18                                                          (2) INFORMATION FOR SEQ ID NO:1152:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1152:                                    GGAAGCUGUCUUCAGACA18                                                          (2) INFORMATION FOR SEQ ID NO:1153:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1153:                                    CUGAGCUGUCCCCACCUG18                                                          (2) INFORMATION FOR SEQ ID NO:1154:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1154:                                    UAACGCUGAUUUGGUGAC18                                                          (2) INFORMATION FOR SEQ ID NO:1155:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1155:                                    CCAGGCUGUCGCUACAUC18                                                          (2) INFORMATION FOR SEQ ID NO:1156:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 18 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1156:                                    AACCUCUGCUCCCCACGG18                                                          (2) INFORMATION FOR SEQ ID NO:1157:                                           (i) SEQUENCE CHARACTERISTICS:                                                 (A) LENGTH: 12 base pairs                                                     (B) TYPE: nucleic acid                                                        (C) STRANDEDNESS: single                                                      (D) TOPOLOGY: linear                                                          (xi) SEQUENCE DESCRIPTION: SEQ ID NO:1157:                                    GGCCGAAAGGCC12                                                                __________________________________________________________________________

We claim:
 1. An enzymatic RNA molecule which cleaves TNF-α mRNA whereinsaid enzymatic RNA molecule comprises sequences complementary to any ofsequences defined as Seq ID Nos. 15-267, 522-772, 1058-1090, or1124-1156.
 2. An enzymatic RNA molecule which cleaves TNF-α mRNA thebinding arms of which contain sequences complementary to the sequencesdefined as Seq. ID Nos. 15-267 or 522-772, wherein said enzymatic RNAmolecule is in a hammerhead motif.
 3. An enzymatic RNA molecule whichcleaves TNF-α mRNA, the binding arms of which contain sequencescomplementary to the sequences defined as Seq. ID Nos. 1058-1090 or1124-1156, wherein said enzymatic RNA molecule is in a hairpin motif. 4.The enzymatic RNA molecule of claim 2 or 3, wherein said ribozymecomprises between 12 and 100 bases complementary to said mRNA.
 5. Theenzymatic RNA molecule of claim 4, wherein said ribozyme comprisesbetween 14 and 24 bases complementary to said mRNA.
 6. The enzymatic RNAmolecule of claim 2, wherein said enzymatic RNA molecule comprises anysequence selected from the group consisting of Sequence ID Nos. 268-521,and 773-1024.
 7. A mammalian cell in vitro including an enzymatic RNAmolecule of claims 2 or
 3. 8. The cell of claim 7, wherein said cell isa human cell.
 9. An expression vector including nucleic acid encoding anenzymatic RNA molecule or multiple enzymatic molecules of claims 1, 2,or 3 in a manner which allows expression of that enzymatic RNAmolecule(s) within a mammalian cell in vitro.
 10. A mammalian cellincluding an expression vector of claim
 9. 11. The cell of claim 10,wherein said cell is a human cell.
 12. The enzymatic RNA molecule ofclaim 1, wherein said enzymatic RNA molecule comprises at least onesugar modification.
 13. The enzymatic RNA molecule of claim 3, whereinsaid enzymatic RNA molecule comprises any sequence selected from thegroup consisting of Sequence ID Nos. 1025-1057, and 1091-1123.